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Syreeta Tilghman

TitleAssociate Professor
Faculty RankAssociate Professor
InstitutionFlorida A&M University
DepartmentCoPPS, IPH Pharmaceutical Sciences
Address1415 S Martin Luther King Jr Blvd
Tallahassee FL 32307
Phone8505993933
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    Collapse Biography 
    Collapse awards and honors
    2014Norman C Francis Faculty Excellence Award for Excellence in Scholarship, Xavier University of Louisiana
    2017AACR-MICR Minority & Minority-Serving Institution Faculty Scholar Award
    2017 - 2018FAMU College of Pharmacy and Pharmaceutical Sciences Teacher of the Year, Florida A&M University
    2017NIH Early Career Reviewer
    2018 - 2022NIH SCORE1 Award, National Institutes of Health
    2018 - 2019Cancer Biology & Therapeutics: High Impact in Cancer Research Certification Program, Harvard Medical School
    2018 - 2019FAMU Emerging Researcher of the Year Award, Florida A&M University
    2021 - 2027Standing member of NIH Mechanisms of Cancer Therapeutics 1 (MCT1) Study Section, Center for Scientific Review National Institutes of Health

    Collapse Research 
    Collapse research activities and funding
    F31CA083172     (TILGHMAN, SYREETA)Mar 24, 2000
    NIH/NCI
    MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Role: Principal Investigator
    SC2CA182842     (TILGHMAN, SYREETA L)Jul 2, 2013 - Jun 30, 2017
    NIH
    Second line breast cancer therapy through a novel Phytoantiestrogen
    Role: Principal Investigator
    SC1GM125617     (TILGHMAN, SYREETA L)Aug 1, 2018 - Jul 31, 2022
    NIH
    Second line breast cancer therapy alters aromatase inhibitor resistant metastasis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ferguson DT, Taka E, Tilghman SL, Womble T, Redmond BV, Gedeon S, Flores-Rozas H, Reed SL, Soliman KFA, Kanga KJW, Darling-Reed SF. The Anticancer Effects of the Garlic Organosulfide Diallyl Trisulfide through the Attenuation of B[a]P-Induced Oxidative Stress, AhR Expression, and DNA Damage in Human Premalignant Breast Epithelial (MCF-10AT1) Cells. Int J Mol Sci. 2024 Jan 11; 25(2). PMID: 38255999.
      Citations: 1     Fields:    Translation:HumansAnimals
    2. Patel JR, Banjara B, Ohemeng A, Davidson AM, Bou? SM, Burow ME, Tilghman SL. Novel Therapeutic Combination Targets the Growth of Letrozole-Resistant Breast Cancer through Decreased Cyclin B1. Nutrients. 2023 Mar 28; 15(7). PMID: 37049472.
      Citations: 1     Fields:    Translation:HumansCells
    3. Patel JR, Thangavelu P, Terrell RM, Israel B, Sarkar AB, Davidson AM, Zhang K, Khupse R, Tilghman SL. A Novel Allosteric Inhibitor Targets PLK1 in Triple Negative Breast Cancer Cells. Biomolecules. 2022 03 31; 12(4). PMID: 35454120.
      Citations: 1     Fields:    Translation:HumansCells
    4. Walker RR, Patel JR, Gupta A, Davidson AM, Williams CC, Payton-Stewart F, Bou? SM, Burow ME, Khupse R, Tilghman SL. Glyceollins Trigger Anti-Proliferative Effects in Hormone-Dependent Aromatase-Inhibitor-Resistant Breast Cancer Cells through the Induction of Apoptosis. Int J Mol Sci. 2022 Mar 07; 23(5). PMID: 35270029.
      Citations: 4     Fields:    Translation:HumansCells
    5. Darling-Reed SF, Nkrumah-Elie Y, Ferguson DT, Flores-Rozas H, Mendonca P, Messeha S, Hudson A, Badisa RB, Tilghman SL, Womble T, Day A, Jett M, Hammamieh R, Soliman KFA. Diallyl Sulfide Attenuation of Carcinogenesis in Mammary Epithelial Cells through the Inhibition of ROS Formation, and DNA Strand Breaks. Biomolecules. 2021 09 06; 11(9). PMID: 34572526.
      Citations: 3     Fields:    Translation:HumansCells
    6. Patel JR, Gallegos KM, Walker RR, Davidson AM, Davenport I, Tilghman SL. Mammospheres of letrozole-resistant breast cancer cells enhance breast cancer aggressiveness. Oncol Lett. 2021 Aug; 22(2):620. PMID: 34267813.
      Citations:    
    7. Gallegos KM, Patel JR, Llopis SD, Walker RR, Davidson AM, Zhang W, Zhang K, Tilghman SL. Quantitative Proteomic Profiling Identifies a Potential Novel Chaperone Marker in Resistant Breast Cancer. Front Oncol. 2021; 11:540134. PMID: 33718123.
      Citations:    
    8. Walker RR, Gallegos KM, Bratton MR, Lemieux KP, Zhang K, Wang G, Davidson AM, Tilghman SL. Acquisition of Letrozole Resistance Through Activation of the p38/MAPK Signaling Cascade. Anticancer Res. 2021 Feb; 41(2):583-599. PMID: 33517263.
      Citations: 4     Fields:    Translation:HumansCells
    9. Gupta A, Gupta G, Mehta RR, Ivancic DZ, Walker RR, Patel JR, Gallegos KM, Davidson AM, Khan SA, Mehta RG, Tilghman SL. A novel and cost-effective ex vivo orthotopic model for the study of human breast cancer in mouse mammary gland organ culture. Biol Open. 2020 05 29; 9(5). PMID: 32366373.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Israel BB, Tilghman SL, Parker-Lemieux K, Payton-Stewart F. Phytochemicals: Current strategies for treating breast cancer. Oncol Lett. 2018 May; 15(5):7471-7478. PMID: 29755596.
      Citations:    
    11. Williams MD, Nguyen T, Carriere PP, Tilghman SL, Williams C. Protein Kinase CK2 Expression Predicts Relapse Survival in ERa Dependent Breast Cancer, and Modulates ERa Expression in Vitro. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010036. PMID: 26703694.
      Citations: 8     Fields:    Translation:HumansCells
    12. Carriere PP, Llopis SD, Naiki AC, Nguyen G, Phan T, Nguyen MM, Preyan LC, Yearby L, Pratt J, Burks H, Davenport IR, Nguyen TA, Parker-Lemieux K, Payton-Stewart F, Williams CC, Bou? SM, Burow ME, Collins-Burow B, Hilliard A, Davidson AM, Tilghman SL. Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer through ZEB1. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010010. PMID: 26703648.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    13. Payton-Stewart F, Tilghman SL, Williams LG, Winfield LL. Benzimidazoles diminish ERE transcriptional activity and cell growth in breast cancer cells. Biochem Biophys Res Commun. 2014 Aug 08; 450(4):1358-62. PMID: 24997336.
      Citations: 4     Fields:    Translation:HumansCells
    14. Tilghman SL, Townley I, Zhong Q, Carriere PP, Zou J, Llopis SD, Preyan LC, Williams CC, Skripnikova E, Bratton MR, Zhang Q, Wang G. Proteomic signatures of acquired letrozole resistance in breast cancer: suppressed estrogen signaling and increased cell motility and invasiveness. Mol Cell Proteomics. 2013 Sep; 12(9):2440-55. PMID: 23704778.
      Citations: 36     Fields:    Translation:HumansCells
    15. Tilghman SL, Rhodes LV, Bratton MR, Carriere P, Preyan LC, Boue SM, Vasaitis TS, McLachlan JA, Burow ME. Phytoalexins, miRNAs and breast cancer: a review of phytochemical-mediated miRNA regulation in breast cancer. J Health Care Poor Underserved. 2013 Feb; 24(1 Suppl):36-46. PMID: 23395943.
      Citations: 8     Fields:    Translation:Humans
    16. Johnson KP, Yearby LA, Stoute D, Burow ME, Rhodes LV, Gray M, Carriere P, Tilghman SL, McLachlan JA, Ochieng J. In vitro and in vivo evaluation of novel anticancer agents in triple negative breast cancer models. J Health Care Poor Underserved. 2013 Feb; 24(1 Suppl):104-11. PMID: 23395947.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    17. Martin EC, Bratton MR, Zhu Y, Rhodes LV, Tilghman SL, Collins-Burow BM, Burow ME. Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line. PLoS One. 2012; 7(11):e49067. PMID: 23226206.
      Citations: 10     Fields:    Translation:HumansCells
    18. Bratton MR, Antoon JW, Duong BN, Frigo DE, Tilghman S, Collins-Burow BM, Elliott S, Tang Y, Melnik LI, Lai L, Alam J, Beckman BS, Hill SM, Rowan BG, McLachlan JA, Burow ME. Gao potentiates estrogen receptor a activity via the ERK signaling pathway. J Endocrinol. 2012 Jul; 214(1):45-54. PMID: 22562654.
      Citations: 10     Fields:    Translation:HumansCells
    19. Tilghman SL, Bratton MR, Segar HC, Martin EC, Rhodes LV, Li M, McLachlan JA, Wiese TE, Nephew KP, Burow ME. Endocrine disruptor regulation of microRNA expression in breast carcinoma cells. PLoS One. 2012; 7(3):e32754. PMID: 22403704.
      Citations: 63     Fields:    Translation:HumansCells
    20. McLachlan JA, Tilghman SL, Burow ME, Bratton MR. Environmental signaling and reproduction: a comparative biological and chemical perspective. Mol Cell Endocrinol. 2012 May 06; 354(1-2):60-2. PMID: 22178089.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    21. Rhodes LV, Tilghman SL, Boue SM, Wang S, Khalili H, Muir SE, Bratton MR, Zhang Q, Wang G, Burow ME, Collins-Burow BM. Glyceollins as novel targeted therapeutic for the treatment of triple-negative breast cancer. Oncol Lett. 2012 Jan; 3(1):163-171. PMID: 22740874.
      Citations:    
    22. Rhodes LV, Bratton MR, Zhu Y, Tilghman SL, Muir SE, Salvo VA, Tate CR, Elliott S, Nephew KP, Collins-Burow BM, Burow ME. Effects of SDF-1-CXCR4 signaling on microRNA expression and tumorigenesis in estrogen receptor-alpha (ER-a)-positive breast cancer cells. Exp Cell Res. 2011 Nov 01; 317(18):2573-81. PMID: 21906588.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    23. Tilghman SL, Sabnis G, Brodie AM. Upregulation of AIB1, aromatase and ERa provides long-term estrogen-deprived human breast cancer cells with a mechanistic growth advantage for survival. Horm Mol Biol Clin Investig. 2011 Jan 01; 3(1):357-366. PMID: 23606920.
      Citations: 6     Fields:    
    24. Tilghman SL, Sabnis G, Brodie AM. Upregulation of AIB1, aromatase and ERa provides long-term estrogen-deprived human breast cancer cells with a mechanistic growth advantage for survival. Horm Mol Biol Clin Investig. 2010 Dec 01; 3(1):357-66. PMID: 25961207.
      Citations:    Fields:    
    25. Rhodes LV, Short SP, Neel NF, Salvo VA, Zhu Y, Elliott S, Wei Y, Yu D, Sun M, Muir SE, Fonseca JP, Bratton MR, Segar C, Tilghman SL, Sobolik-Delmaire T, Horton LW, Zaja-Milatovic S, Collins-Burow BM, Wadsworth S, Beckman BS, Wood CE, Fuqua SA, Nephew KP, Dent P, Worthylake RA, Curiel TJ, Hung MC, Richmond A, Burow ME. Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer Res. 2011 Jan 15; 71(2):603-13. PMID: 21123450.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    26. Syreeta L. Tilghman, Stephen M. Boué and Matthew E. Burow . Glyceollins, A Novel Class of Antiestrogenic Phytoalexins. 2010; 4(2):155-160. View Publication.
    27. Payton-Stewart F, Khupse RS, Bou? SM, Elliott S, Zimmermann MC, Skripnikova EV, Ashe H, Tilghman SL, Beckman BS, Cleveland TE, McLachlan JA, Bhatnagar D, Wiese TE, Erhardt P, Burow ME. Glyceollin I enantiomers distinctly regulate ER-mediated gene expression. Steroids. 2010 Dec; 75(12):870-8. PMID: 20493896.
      Citations: 10     Fields:    Translation:HumansCells
    28. Tilghman SL, Nierth-Simpson EN, Wallace R, Burow ME, McLachlan JA. Environmental hormones: Multiple pathways for response may lead to multiple disease outcomes. Steroids. 2010 Aug-Sep; 75(8-9):520-3. PMID: 20466011.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    29. Zimmermann MC, Tilghman SL, Bou? SM, Salvo VA, Elliott S, Williams KY, Skripnikova EV, Ashe H, Payton-Stewart F, Vanhoy-Rhodes L, Fonseca JP, Corbitt C, Collins-Burow BM, Howell MH, Lacey M, Shih BY, Carter-Wientjes C, Cleveland TE, McLachlan JA, Wiese TE, Beckman BS, Burow ME. Glyceollin I, a novel antiestrogenic phytoalexin isolated from activated soy. J Pharmacol Exp Ther. 2010 Jan; 332(1):35-45. PMID: 19797619.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    30. Rhodes LV, Muir SE, Elliott S, Guillot LM, Antoon JW, Penfornis P, Tilghman SL, Salvo VA, Fonseca JP, Lacey MR, Beckman BS, McLachlan JA, Rowan BG, Pochampally R, Burow ME. Adult human mesenchymal stem cells enhance breast tumorigenesis and promote hormone independence. Breast Cancer Res Treat. 2010 Jun; 121(2):293-300. PMID: 19597705.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    31. Bou? SM, Tilghman SL, Elliott S, Zimmerman MC, Williams KY, Payton-Stewart F, Miraflor AP, Howell MH, Shih BY, Carter-Wientjes CH, Segar C, Beckman BS, Wiese TE, Cleveland TE, McLachlan JA, Burow ME. Identification of the potent phytoestrogen glycinol in elicited soybean (Glycine max). Endocrinology. 2009 May; 150(5):2446-53. PMID: 19116342.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    32. Macedo LF, Guo Z, Tilghman SL, Sabnis GJ, Qiu Y, Brodie A. Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole. Cancer Res. 2006 Aug 01; 66(15):7775-82. PMID: 16885381.
      Citations: 59     Fields:    Translation:HumansCells
    33. Brodie A, Jelovac D, Macedo L, Sabnis G, Tilghman S, Goloubeva O. Therapeutic observations in MCF-7 aromatase xenografts. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 2):884s-8s. PMID: 15701882.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    34. Long BJ, Tilghman SL, Yue W, Thiantanawat A, Grigoryev DN, Brodie AM. The steroidal antiestrogen ICI 182,780 is an inhibitor of cellular aromatase activity. J Steroid Biochem Mol Biol. 1998 Nov; 67(4):293-304. PMID: 9883986.
      Citations: 16     Fields:    Translation:HumansCells
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