Receptors, LDL

"Receptors, LDL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.

Descriptor ID	D011973
MeSH Number(s)	D12.776.543.750.710.450
Concept/Terms	Receptors, LDL Receptors, LDL LDL Receptors LDL Receptors, Lipoprotein Receptors, Lipoprotein LDL Lipoprotein LDL Receptors Low Density Lipoprotein Receptors Receptors, Lipoprotein, LDL Receptors, Low Density Lipoprotein LDL Receptor Receptor, LDL Low Density Lipoprotein Receptor

Below are MeSH descriptors whose meaning is more general than "Receptors, LDL".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Lipoprotein [D12.776.543.750.710]
Receptors, LDL [D12.776.543.750.710.450]

Below are MeSH descriptors whose meaning is related to "Receptors, LDL".

Below are MeSH descriptors whose meaning is more specific than "Receptors, LDL".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, LDL" by people in this website by year, and whether "Receptors, LDL" was a major or minor topic of these publications.

Bar chart showing 28 publications over 18 distinct years, with a maximum of 3 publications in 2012 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	1	0	1
2002	2	0	2
2004	1	1	2
2005	0	1	1
2008	0	1	1
2009	2	0	2
2011	2	0	2
2012	2	1	3
2013	0	1	1
2014	0	2	2
2015	1	1	2
2016	2	1	3
2018	1	0	1
2020	0	1	1
2021	1	0	1
2023	0	1	1
2024	1	0	1
2025	0	1	1

Below are the most recent publications written about "Receptors, LDL" by people in Profiles.

Cheng J, Cheng M, Sinha S, Cely I, Gladkikh S, Han MT, Zhang G, Zhou Z, Chugh R, Ahn IS, Diamante G, Wang YC, Wang Z, Bennett BJ, Cai H, Allayee H, Hazen SL, Lusis AJ, Shih DM, Yang X. Trimethylamine-N-Oxide Affects Cell Type-Specific Pathways and Networks in Mouse Aorta to Promote Atherosclerotic Plaque Vulnerability. Arterioscler Thromb Vasc Biol. 2025 Oct; 45(10):1784-1798.

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Hajri T, Gharib M, Fungwe T, M'Koma A. Very low-density lipoprotein receptor mediates triglyceride-rich lipoprotein-induced oxidative stress and insulin resistance. Am J Physiol Heart Circ Physiol. 2024 10 01; 327(4):H733-H748.

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Li Q, Morrill NK, Moerman-Herzog AM, Barger SW, Joly-Amado A, Peters M, Soueidan H, Diemler C, Prabhudeva S, Weeber EJ, Nash KR. Central repeat fragment of reelin leads to active reelin intracellular signaling and rescues cognitive deficits in a mouse model of reelin deficiency. Cell Signal. 2023 09; 109:110763.

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Okoro EU. TNFa-Induced LDL Cholesterol Accumulation Involve Elevated LDLR Cell Surface Levels and SR-B1 Downregulation in Human Arterial Endothelial Cells. Int J Mol Sci. 2021 Jun 09; 22(12).

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Sinha SK, Miikeda A, Fouladian Z, Mehrabian M, Edillor C, Shih D, Zhou Z, Paul MK, Charugundla S, Davis RC, Rajavashisth TB, Lusis AJ. Local M-CSF (Macrophage Colony-Stimulating Factor) Expression Regulates Macrophage Proliferation and Apoptosis in Atherosclerosis. Arterioscler Thromb Vasc Biol. 2021 01; 41(1):220-233.

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Wang G, Guo Z, Tong L, Xue F, Krafft PR, Budbazar E, Zhang JH, Tang J. TLR7 (Toll-Like Receptor 7) Facilitates Heme Scavenging Through the BTK (Bruton Tyrosine Kinase)-CRT (Calreticulin)-LRP1 (Low-Density Lipoprotein Receptor-Related Protein-1)-Hx (Hemopexin) Pathway in Murine Intracerebral Hemorrhage. Stroke. 2018 12; 49(12):3020-3029.

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Reaves DK, Hoadley KA, Fagan-Solis KD, Jima DD, Bereman M, Thorpe L, Hicks J, McDonald D, Troester MA, Perou CM, Fleming JM. Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis. Mol Cancer Res. 2017 02; 15(2):165-178.

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Baumer Y, McCurdy S, Alcala M, Mehta N, Lee BH, Ginsberg MH, Boisvert WA. CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis. Atherosclerosis. 2017 01; 256:105-114.

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Hossain A, Tauhid L, Davenport I, Huckaba T, Graves R, Mandal T, Muniruzzaman S, Ahmed SA, Bhattacharjee PS. LRP-1 Pathway Targeted Inhibition of Vascular Abnormalities in the Retina of Diabetic Mice. Curr Eye Res. 2017 04; 42(4):640-647.

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Khera AV, Won HH, Peloso GM, Lawson KS, Bartz TM, Deng X, van Leeuwen EM, Natarajan P, Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N, Nomura A, Kessler T, Duga S, Bis JC, van Duijn CM, Cupples LA, Psaty B, Rader DJ, Danesh J, Schunkert H, McPherson R, Farrall M, Watkins H, Lander E, Wilson JG, Correa A, Boerwinkle E, Merlini PA, Ardissino D, Saleheen D, Gabriel S, Kathiresan S. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J Am Coll Cardiol. 2016 06 07; 67(22):2578-89.

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