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Eunsook Lee, PhD

TitleProfessor, Division of Pharmaceutical Sciences
InstitutionFlorida A&M University
DepartmentProfessor in Pharmaceutical Sciences
Address1601 S Martin Luther King Jr Blvd
Tallahassee FL 32307
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Aschner M, Skalny AV, Santamaria A, Rocha JBT, Mansouri B, Tizabi Y, Madeddu R, Lu R, Lee E, Tinkov AA. Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer's Disease: A Focus on Non-Coding RNAs. Neurochem Res. 2024 Jul 27. PMID: 39060769.
      Citations:    Fields:    
    2. Nyarko-Danquah I, Pajarillo E, Kim S, Digman A, Multani HK, Ajayi I, Son DS, Aschner M, Lee E. Microglial Sp1 induced LRRK2 upregulation in response to manganese exposure, and 17?-estradiol afforded protection against this manganese toxicity. Neurotoxicology. 2024 Jul; 103:105-114. PMID: 38857675.
      Citations:    Fields:    Translation:AnimalsCells
    3. Aschner M, Skalny AV, Paoliello MMB, Tinkova MN, Martins AC, Santamaria A, Lee E, Rocha JBT, Farsky SHP, Tinkov AA. Retinal toxicity of heavy metals and its involvement in retinal pathology. Food Chem Toxicol. 2024 Jun; 188:114685. PMID: 38663763.
      Citations:    Fields:    Translation:HumansAnimals
    4. Kim J, Pajarillo E, Rizor A, Son DS, Lee J, Aschner M, Lee E. Correction: LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PLoS One. 2024; 19(3):e0300095. PMID: 38427617.
      Citations:    Fields:    
    5. Pajarillo E, Kim S, Digman A, Dutton M, Son DS, Aschner M, Lee E. The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. J Biol Chem. 2023 07; 299(7):104879. PMID: 37269951.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    6. Pajarillo E, Kim SH, Digman A, Dutton M, Son DS, Aschner M, Lee E. The role of microglial LRRK2 in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. bioRxiv. 2023 Apr 05. PMID: 37066140.
      Citations:    
    7. Kim S, Pajarillo E, Nyarko-Danquah I, Aschner M, Lee E. Role of Astrocytes in Parkinson's Disease Associated with Genetic Mutations and Neurotoxicants. Cells. 2023 02 15; 12(4). PMID: 36831289.
      Citations: 5     Fields:    Translation:HumansCells
    8. Pajarillo E, Nyarko-Danquah I, Digman A, Multani HK, Kim S, Gaspard P, Aschner M, Lee E. Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies. Front Pharmacol. 2022; 13:1011947. PMID: 36605395.
      Citations:    
    9. Pajarillo E, Nyarko-Danquah I, Digman A, Vied C, Son DS, Lee J, Aschner M, Lee E. Astrocytic Yin Yang 1 is critical for murine brain development and protection against apoptosis, oxidative stress, and inflammation. Glia. 2023 02; 71(2):450-466. PMID: 36300569.
      Citations: 4     Fields:    Translation:Animals
    10. Pajarillo E, Demayo M, Digman A, Nyarko-Danquah I, Son DS, Aschner M, Lee E. Deletion of RE1-silencing transcription factor in striatal astrocytes exacerbates manganese-induced neurotoxicity in mice. Glia. 2022 10; 70(10):1886-1901. PMID: 35638297.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    11. Rizor A, Pajarillo E, Son DS, Aschner M, Lee E. Manganese phosphorylates Yin Yang 1 at serine residues to repress EAAT2 in human H4 astrocytes. Toxicol Lett. 2022 Feb 01; 355:41-46. PMID: 34800614.
      Citations: 2     Fields:    Translation:HumansCells
    12. Pajarillo E, Digman A, Nyarko-Danquah I, Son DS, Soliman KFA, Aschner M, Lee E. Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity. J Biol Chem. 2021 12; 297(6):101372. PMID: 34756885.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    13. Tinkov AA, Martins AC, Avila DS, Gritsenko VA, Skalny AV, Santamaria A, Lee E, Bowman AB, Aschner M. Gut Microbiota as a Potential Player in Mn-Induced Neurotoxicity. Biomolecules. 2021 08 31; 11(9). PMID: 34572505.
      Citations: 13     Fields:    Translation:HumansAnimals
    14. Rizor A, Pajarillo E, Nyarko-Danquah I, Digman A, Mooneyham L, Son DS, Aschner M, Lee E. Manganese-induced reactive oxygen species activate I?B kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro. Neurotoxicology. 2021 09; 86:94-103. PMID: 34310962.
      Citations: 4     Fields:    Translation:HumansCells
    15. Pajarillo EAB, Lee E, Kang DK. Trace metals and animal health: Interplay of the gut microbiota with iron, manganese, zinc, and copper. Anim Nutr. 2021 Sep; 7(3):750-761. PMID: 34466679.
      Citations:    
    16. Tinkov AA, Paoliello MMB, Mazilina AN, Skalny AV, Martins AC, Voskresenskaya ON, Aaseth J, Santamaria A, Notova SV, Tsatsakis A, Lee E, Bowman AB, Aschner M. Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update. Int J Mol Sci. 2021 Apr 28; 22(9). PMID: 33925013.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    17. Martins AC, Ruella Oliveira S, Barbosa F, Tinkov AA, V Skalny A, Santamar?a A, Lee E, Bowman AB, Aschner M. Evaluating the risk of manganese-induced neurotoxicity of parenteral nutrition: review of the current literature. Expert Opin Drug Metab Toxicol. 2021 May; 17(5):581-593. PMID: 33620266.
      Citations: 5     Fields:    Translation:HumansAnimals
    18. Pajarillo E, Nyarko-Danquah I, Adinew G, Rizor A, Aschner M, Lee E. Neurotoxicity mechanisms of manganese in the central nervous system. Adv Neurotoxicol. 2021; 5:215-238. PMID: 34263091.
      Citations:    
    19. Nyarko-Danquah I, Pajarillo E, Digman A, Soliman KFA, Aschner M, Lee E. Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms. Molecules. 2020 Dec 12; 25(24). PMID: 33322668.
      Citations: 21     Fields:    Translation:HumansAnimals
    20. Pajarillo E, Johnson J, Rizor A, Nyarko-Danquah I, Adinew G, Bornhorst J, Stiboller M, Schwerdtle T, Son DS, Aschner M, Lee E. Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity. J Biol Chem. 2020 11 13; 295(46):15662-15676. PMID: 32893191.
      Citations: 18     Fields:    Translation:AnimalsCells
    21. Martins AC, Gubert P, Villas Boas GR, Meirelles Paes M, Santamar?a A, Lee E, Tinkov AA, Bowman AB, Aschner M. Manganese-induced neurodegenerative diseases and possible therapeutic approaches. Expert Rev Neurother. 2020 11; 20(11):1109-1121. PMID: 32799578.
      Citations: 19     Fields:    Translation:Humans
    22. Pajarillo E, Rizor A, Son DS, Aschner M, Lee E. The transcription factor REST up-regulates tyrosine hydroxylase and antiapoptotic genes and protects dopaminergic neurons against manganese toxicity. J Biol Chem. 2020 03 06; 295(10):3040-3054. PMID: 32001620.
      Citations: 14     Fields:    Translation:AnimalsCells
    23. Ke T, Sidoryk-Wegrzynowicz M, Pajarillo E, Rizor A, Soares FAA, Lee E, Aschner M. Role of Astrocytes in Manganese Neurotoxicity Revisited. Neurochem Res. 2019 Nov; 44(11):2449-2459. PMID: 31571097.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    24. Martins AC, Morcillo P, Ijomone OM, Venkataramani V, Harrison FE, Lee E, Bowman AB, Aschner M. New Insights on the Role of Manganese in Alzheimer's Disease and Parkinson's Disease. Int J Environ Res Public Health. 2019 09 22; 16(19). PMID: 31546716.
      Citations: 29     Fields:    Translation:HumansAnimals
    25. Rizor A, Pajarillo E, Johnson J, Aschner M, Lee E. Astrocytic Oxidative/Nitrosative Stress Contributes to Parkinson's Disease Pathogenesis: The Dual Role of Reactive Astrocytes. Antioxidants (Basel). 2019 Aug 01; 8(8). PMID: 31374936.
      Citations:    
    26. Pajarillo E, Rizor A, Lee J, Aschner M, Lee E. The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics. Neuropharmacology. 2019 12 15; 161:107559. PMID: 30851309.
      Citations: 135     Fields:    Translation:HumansAnimalsCells
    27. Kim J, Pajarillo E, Rizor A, Son DS, Lee J, Aschner M, Lee E. LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PLoS One. 2019; 14(1):e0210248. PMID: 30645642.
      Citations: 30     Fields:    Translation:HumansCells
    28. Pajarillo E, Rizor A, Lee J, Aschner M, Lee E. The role of posttranslational modifications of a-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors. Biochim Biophys Acta Mol Basis Dis. 2019 08 01; 1865(8):1992-2000. PMID: 30481588.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    29. Johnson J, Pajarillo E, Karki P, Kim J, Son DS, Aschner M, Lee E. Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity. Neurotoxicology. 2018 07; 67:112-120. PMID: 29778792.
      Citations: 25     Fields:    Translation:AnimalsCells
    30. Pajarillo E, Johnson J, Kim J, Karki P, Son DS, Aschner M, Lee E. 17?-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity. Neurotoxicology. 2018 03; 65:280-288. PMID: 29183790.
      Citations: 22     Fields:    Translation:AnimalsCells
    31. Karki P, Hong P, Johnson J, Pajarillo E, Son DS, Aschner M, Lee EY. Arundic Acid Increases Expression and Function of Astrocytic Glutamate Transporter EAAT1 Via the ERK, Akt, and NF-?B Pathways. Mol Neurobiol. 2018 Jun; 55(6):5031-5046. PMID: 28812276.
      Citations: 14     Fields:    Translation:HumansCells
    32. Johnson J, Pajarillo EAB, Taka E, Reams R, Son DS, Aschner M, Lee E. Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice. Neurotoxicology. 2018 01; 64:230-239. PMID: 28610743.
      Citations: 22     Fields:    Translation:AnimalsCells
    33. Lee E, Karki P, Johnson J, Hong P, Aschner M. Manganese Control of Glutamate Transporters' Gene Expression. Adv Neurobiol. 2017; 16:1-12. PMID: 28828603.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    34. Karki P, Johnson J, Son DS, Aschner M, Lee E. Transcriptional Regulation of Human Transforming Growth Factor-a in Astrocytes. Mol Neurobiol. 2017 03; 54(2):964-976. PMID: 26797516.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    35. Karki P, Kim C, Smith K, Son DS, Aschner M, Lee E. Transcriptional Regulation of the Astrocytic Excitatory Amino Acid Transporter 1 (EAAT1) via NF-?B and Yin Yang 1 (YY1). J Biol Chem. 2015 Sep 25; 290(39):23725-37. PMID: 26269591.
      Citations: 37     Fields:    Translation:AnimalsCells
    36. Chen P, Chakraborty S, Mukhopadhyay S, Lee E, Paoliello MM, Bowman AB, Aschner M. Manganese homeostasis in the nervous system. J Neurochem. 2015 Aug; 134(4):601-10. PMID: 25982296.
      Citations: 111     Fields:    Translation:HumansAnimals
    37. Khabele D, Kabir SM, Dong Y, Lee E, Rice VM, Son DS. Preferential effect of akt2-dependent signaling on the cellular viability of ovarian cancer cells in response to EGF. J Cancer. 2014; 5(8):670-8. PMID: 25258648.
      Citations:    
    38. Karki P, Smith K, Johnson J, Aschner M, Lee E. Role of transcription factor yin yang 1 in manganese-induced reduction of astrocytic glutamate transporters: Putative mechanism for manganese-induced neurotoxicity. Neurochem Int. 2015 Sep; 88:53-9. PMID: 25128239.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    39. Karki P, Smith K, Johnson J, Aschner M, Lee EY. Genetic dys-regulation of astrocytic glutamate transporter EAAT2 and its implications in neurological disorders and manganese toxicity. Neurochem Res. 2015 Feb; 40(2):380-8. PMID: 25064045.
      Citations: 17     Fields:    Translation:HumansCells
    40. Exil V, Ping L, Yu Y, Chakraborty S, Caito SW, Wells KS, Karki P, Lee E, Aschner M. Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures. PLoS One. 2014; 9(5):e94753. PMID: 24787138.
      Citations: 24     Fields:    Translation:AnimalsCells
    41. Karki P, Webb A, Zerguine A, Choi J, Son DS, Lee E. Mechanism of raloxifene-induced upregulation of glutamate transporters in rat primary astrocytes. Glia. 2014 Aug; 62(8):1270-83. PMID: 24782323.
      Citations: 38     Fields:    Translation:AnimalsCells
    42. Karki P, Webb A, Smith K, Johnson J, Lee K, Son DS, Aschner M, Lee E. Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes. Mol Cell Biol. 2014 Apr; 34(7):1280-9. PMID: 24469401.
      Citations: 53     Fields:    Translation:AnimalsCells
    43. Karki P, Smith K, Johnson J, Lee E. Astrocyte-derived growth factors and estrogen neuroprotection: role of transforming growth factor-a in estrogen-induced upregulation of glutamate transporters in astrocytes. Mol Cell Endocrinol. 2014 May 25; 389(1-2):58-64. PMID: 24447465.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    44. Cho M, Kabir SM, Dong Y, Lee E, Rice VM, Khabele D, Son DS. Aspirin Blocks EGF-stimulated Cell Viability in a COX-1 Dependent Manner in Ovarian Cancer Cells. J Cancer. 2013; 4(8):671-8. PMID: 24155779.
      Citations:    
    45. Karki P, Webb A, Smith K, Lee K, Son DS, Aschner M, Lee E. cAMP response element-binding protein (CREB) and nuclear factor ?B mediate the tamoxifen-induced up-regulation of glutamate transporter 1 (GLT-1) in rat astrocytes. J Biol Chem. 2013 Oct 04; 288(40):28975-86. PMID: 23955341.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    46. Son DS, Kabir SM, Dong Y, Lee E, Adunyah SE. Characteristics of chemokine signatures elicited by EGF and TNF in ovarian cancer cells. J Inflamm (Lond). 2013 Jun 25; 10(1):25. PMID: 23800251.
      Citations:    
    47. Karki P, Lee E, Aschner M. Manganese neurotoxicity: a focus on glutamate transporters. Ann Occup Environ Med. 2013 May 21; 25(1):4. PMID: 24472696.
      Citations:    
    48. Son DS, Kabir SM, Dong YL, Lee E, Adunyah SE. Inhibitory effect of tumor suppressor p53 on proinflammatory chemokine expression in ovarian cancer cells by reducing proteasomal degradation of I?B. PLoS One. 2012; 7(12):e51116. PMID: 23300534.
      Citations: 34     Fields:    Translation:HumansCells
    49. Lee E, Sidoryk-Wegrzynowicz M, Farina M, Rocha JB, Aschner M. Estrogen attenuates manganese-induced glutamate transporter impairment in rat primary astrocytes. Neurotox Res. 2013 Feb; 23(2):124-30. PMID: 22878846.
      Citations: 12     Fields:    Translation:AnimalsCells
    50. Sidoryk-Wegrzynowicz M, Lee E, Aschner M. Mechanism of Mn(II)-mediated dysregulation of glutamine-glutamate cycle: focus on glutamate turnover. J Neurochem. 2012 Aug; 122(4):856-67. PMID: 22708868.
      Citations: 13     Fields:    Translation:AnimalsCells
    51. Lee E, Sidoryk-W?grzynowicz M, Wang N, Webb A, Son DS, Lee K, Aschner M. GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes. J Biol Chem. 2012 Aug 03; 287(32):26817-28. PMID: 22645130.
      Citations: 46     Fields:    Translation:AnimalsCells
    52. Lee E, Sidoryk-Wegrzynowicz M, Yin Z, Webb A, Son DS, Aschner M. Transforming growth factor-a mediates estrogen-induced upregulation of glutamate transporter GLT-1 in rat primary astrocytes. Glia. 2012 Jul; 60(7):1024-36. PMID: 22488924.
      Citations: 38     Fields:    Translation:AnimalsCells
    53. Lee E, Yin Z, Sidoryk-Wegrzynowicz M, Jiang H, Aschner M. 15-Deoxy-?12,14-prostaglandin J2 modulates manganese-induced activation of the NF-?B, Nrf2, and PI3K pathways in astrocytes. Free Radic Biol Med. 2012 Mar 15; 52(6):1067-74. PMID: 22245093.
      Citations: 19     Fields:    Translation:AnimalsCells
    54. Sidoryk-Wegrzynowicz M, Lee E, Mingwei N, Aschner M. Disruption of astrocytic glutamine turnover by manganese is mediated by the protein kinase C pathway. Glia. 2011 Nov; 59(11):1732-43. PMID: 21812036.
      Citations: 27     Fields:    Translation:AnimalsCells
    55. Yin Z, Lee E, Ni M, Jiang H, Milatovic D, Rongzhu L, Farina M, Rocha JB, Aschner M. Methylmercury-induced alterations in astrocyte functions are attenuated by ebselen. Neurotoxicology. 2011 Jun; 32(3):291-9. PMID: 21300091.
      Citations: 36     Fields:    Translation:AnimalsCells
    56. Le TM, Jiang H, Cunningham GR, Magarik JA, Barge WS, Cato MC, Farina M, Rocha JB, Milatovic D, Lee E, Aschner M, Summar ML. ?-Glutamylcysteine ameliorates oxidative injury in neurons and astrocytes in vitro and increases brain glutathione in vivo. Neurotoxicology. 2011 Oct; 32(5):518-25. PMID: 21159318.
      Citations: 12     Fields:    Translation:AnimalsCells
    57. Sidoryk-Wegrzynowicz M, Wegrzynowicz M, Lee E, Bowman AB, Aschner M. Role of astrocytes in brain function and disease. Toxicol Pathol. 2011 Jan; 39(1):115-23. PMID: 21075920.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    58. Sidoryk-Wegrzynowicz M, Lee E, Albrecht J, Aschner M. Manganese disrupts astrocyte glutamine transporter expression and function. J Neurochem. 2009 Aug; 110(3):822-30. PMID: 19457077.
      Citations: 37     Fields:    Translation:AnimalsCells
    59. Lee E, Williams Z, Goodman CB, Oriaku ET, Harris C, Thomas M, Soliman KF. Effects of NMDA receptor inhibition by phencyclidine on the neuronal differentiation of PC12 cells. Neurotoxicology. 2006 Jul; 27(4):558-66. PMID: 16580729.
      Citations: 2     Fields:    Translation:AnimalsCells
    60. Lee ES, Chen H, Charlton CG, Soliman KF. The role of phospholipid methylation in 1-methyl-4-phenyl-pyridinium ion (MPP+)-induced neurotoxicity in PC12 cells. Neurotoxicology. 2005 Dec; 26(6):945-57. PMID: 15950286.
      Citations: 6     Fields:    Translation:AnimalsCells
    61. Lee ES, Chen H, Soliman KF, Charlton CG. Effects of homocysteine on the dopaminergic system and behavior in rodents. Neurotoxicology. 2005 Jun; 26(3):361-71. PMID: 15935208.
      Citations: 31     Fields:    Translation:AnimalsCells
    62. Lee ES, Soliman KF, Charlton CG. Lysophosphatidylcholine decreases locomotor activities and dopamine turnover rate in rats. Neurotoxicology. 2005 Jan; 26(1):27-38. PMID: 15527871.
      Citations: 7     Fields:    Translation:Animals
    63. Elsisi NS, Darling-Reed S, Lee EY, Oriaku ET, Soliman KF. Ibuprofen and apigenin induce apoptosis and cell cycle arrest in activated microglia. Neurosci Lett. 2005 Feb 28; 375(2):91-6. PMID: 15670648.
      Citations: 25     Fields:    Translation:AnimalsCells
    64. Lee ES, Chen H, Shepherd KR, Lamango NS, Soliman KF, Charlton CG. Inhibitory effects of lysophosphatidylcholine on the dopaminergic system. Neurochem Res. 2004 Jul; 29(7):1333-42. PMID: 15202762.
      Citations: 4     Fields:    Translation:AnimalsCells
    65. Lee ES, Chen H, Shepherd KR, Lamango NS, Soliman KF, Charlton CG. The inhibitory role of methylation on the binding characteristics of dopamine receptors and transporter. Neurosci Res. 2004 Mar; 48(3):335-44. PMID: 15154679.
      Citations: 7     Fields:    Translation:AnimalsCells
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