RCMI Coordinating Center (RCMI CC) Header Logo

Eunsook Y. Lee, R.PH, PhD

TitleDr.
Faculty RankProfessor
InstitutionFlorida A&M University
DepartmentCollege of Pharmacy and Pharmaceutical Sciences, Institute of Public Health
AddressFlorida A&M University
1415 S Martin Luther King Jr Blvd
Tallahassee FL 32307
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kim S, Pajarillo E, Digman A, Ajayi I, Son DS, Aschner M, Lee E. CAD (Cath. a-Differentiated) Cells Produce Dopamine along with Dopamine-Synthesizing Enzymes. Neurochem Res. 2025 Jul 16; 50(4):233. PMID: 40668428.
      Citations:    Fields:    Translation:AnimalsCells
    2. Digman A, Pajarillo E, Kim S, Ajayi I, Son DS, Aschner M, Lee E. Tamoxifen induces protection against manganese toxicity by REST upregulation via the ER-a/Wnt/?-catenin pathway in neuronal cells. J Biol Chem. 2025 06; 301(6):108529. PMID: 40280417.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Kim S, Pajarillo E, Digman A, Ajayi I, Son DS, Aschner M, Lee E. Role of dopaminergic RE1-silencing transcription factor (REST) in manganese-induced behavioral deficits and dysregulating dopaminergic and serotonergic neurotransmission in mice. Neurotoxicology. 2025 May; 108:57-68. PMID: 40057281.
      Citations: 1     Fields:    Translation:AnimalsCells
    4. Pajarillo E, Kim S, Digman A, Ajayi I, Nyarko-Danquah I, Son DS, Aschner M, Lee E. Dopaminergic REST/NRSF is protective against manganese-induced neurotoxicity in mice. J Biol Chem. 2024 09; 300(9):107707. PMID: 39178947.
      Citations: 4     Fields:    Translation:AnimalsCells
    5. Nyarko-Danquah I, Pajarillo E, Kim S, Digman A, Multani HK, Ajayi I, Son DS, Aschner M, Lee E. Microglial Sp1 induced LRRK2 upregulation in response to manganese exposure, and 17?-estradiol afforded protection against this manganese toxicity. Neurotoxicology. 2024 Jul; 103:105-114. PMID: 38857675.
      Citations: 1     Fields:    Translation:AnimalsCells
    6. Pajarillo E, Kim S, Digman A, Dutton M, Son DS, Aschner M, Lee E. The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. J Biol Chem. 2023 07; 299(7):104879. PMID: 37269951.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    7. Rizor A, Pajarillo E, Son DS, Aschner M, Lee E. Manganese phosphorylates Yin Yang 1 at serine residues to repress EAAT2 in human H4 astrocytes. Toxicol Lett. 2022 Feb 01; 355:41-46. PMID: 34800614.
      Citations: 6     Fields:    Translation:HumansCells
    8. Pajarillo E, Digman A, Nyarko-Danquah I, Son DS, Soliman KFA, Aschner M, Lee E. Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity. J Biol Chem. 2021 12; 297(6):101372. PMID: 34756885.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    9. Rizor A, Pajarillo E, Nyarko-Danquah I, Digman A, Mooneyham L, Son DS, Aschner M, Lee E. Manganese-induced reactive oxygen species activate I?B kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro. Neurotoxicology. 2021 09; 86:94-103. PMID: 34310962.
      Citations: 12     Fields:    Translation:HumansCells
    10. Pajarillo E, Johnson J, Rizor A, Nyarko-Danquah I, Adinew G, Bornhorst J, Stiboller M, Schwerdtle T, Son DS, Aschner M, Lee E. Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity. J Biol Chem. 2020 11 13; 295(46):15662-15676. PMID: 32893191.
      Citations: 23     Fields:    Translation:AnimalsCells
    11. Pajarillo E, Rizor A, Son DS, Aschner M, Lee E. The transcription factor REST up-regulates tyrosine hydroxylase and antiapoptotic genes and protects dopaminergic neurons against manganese toxicity. J Biol Chem. 2020 03 06; 295(10):3040-3054. PMID: 32001620.
      Citations: 22     Fields:    Translation:AnimalsCells
    12. Martins AC, Morcillo P, Ijomone OM, Venkataramani V, Harrison FE, Lee E, Bowman AB, Aschner M. New Insights on the Role of Manganese in Alzheimer's Disease and Parkinson's Disease. Int J Environ Res Public Health. 2019 09 22; 16(19). PMID: 31546716.
      Citations: 38     Fields:    Translation:HumansAnimals
    13. Rizor A, Pajarillo E, Johnson J, Aschner M, Lee E. Astrocytic Oxidative/Nitrosative Stress Contributes to Parkinson's Disease Pathogenesis: The Dual Role of Reactive Astrocytes. Antioxidants (Basel). 2019 Aug 01; 8(8). PMID: 31374936.
      Citations:    
    14. Pajarillo E, Rizor A, Lee J, Aschner M, Lee E. The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics. Neuropharmacology. 2019 12 15; 161:107559. PMID: 30851309.
      Citations: 197     Fields:    Translation:HumansAnimalsCells
    15. Pajarillo E, Rizor A, Lee J, Aschner M, Lee E. The role of posttranslational modifications of a-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors. Biochim Biophys Acta Mol Basis Dis. 2019 08 01; 1865(8):1992-2000. PMID: 30481588.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    16. Scarton L, Yoon S, Oh S, Agyare E, Trevino J, Han B, Lee E, Setiawan VW, Permuth JB, Schmittgen TD, Odedina FG, Wilkie DJ. Pancreatic Cancer Related Health Disparities: A Commentary. Cancers (Basel). 2018 Jul 18; 10(7). PMID: 30021952.
      Citations:    
    17. Johnson J, Pajarillo E, Karki P, Kim J, Son DS, Aschner M, Lee E. Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity. Neurotoxicology. 2018 07; 67:112-120. PMID: 29778792.
      Citations: 32     Fields:    Translation:AnimalsCells
    18. Pajarillo E, Johnson J, Kim J, Karki P, Son DS, Aschner M, Lee E. 17?-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity. Neurotoxicology. 2018 03; 65:280-288. PMID: 29183790.
      Citations: 26     Fields:    Translation:AnimalsCells
    19. Karki P, Hong P, Johnson J, Pajarillo E, Son DS, Aschner M, Lee EY. Arundic Acid Increases Expression and Function of Astrocytic Glutamate Transporter EAAT1 Via the ERK, Akt, and NF-?B Pathways. Mol Neurobiol. 2018 Jun; 55(6):5031-5046. PMID: 28812276.
      Citations: 17     Fields:    Translation:HumansCells
    20. Johnson J, Pajarillo EAB, Taka E, Reams R, Son DS, Aschner M, Lee E. Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice. Neurotoxicology. 2018 01; 64:230-239. PMID: 28610743.
      Citations: 30     Fields:    Translation:AnimalsCells
    21. Lee E, Karki P, Johnson J, Hong P, Aschner M. Manganese Control of Glutamate Transporters' Gene Expression. Adv Neurobiol. 2017; 16:1-12. PMID: 28828603.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    22. Karki P, Smith K, Johnson J, Aschner M, Lee EY. Genetic dys-regulation of astrocytic glutamate transporter EAAT2 and its implications in neurological disorders and manganese toxicity. Neurochem Res. 2015 Feb; 40(2):380-8. PMID: 25064045.
      Citations: 21     Fields:    Translation:HumansCells
    23. Lee ES, Chen H, Charlton CG, Soliman KF. The role of phospholipid methylation in 1-methyl-4-phenyl-pyridinium ion (MPP+)-induced neurotoxicity in PC12 cells. Neurotoxicology. 2005 Dec; 26(6):945-57. PMID: 15950286.
      Citations: 6     Fields:    Translation:AnimalsCells
    24. Lee ES, Chen H, Soliman KF, Charlton CG. Effects of homocysteine on the dopaminergic system and behavior in rodents. Neurotoxicology. 2005 Jun; 26(3):361-71. PMID: 15935208.
      Citations: 36     Fields:    Translation:AnimalsCells
    25. Lee ES, Soliman KF, Charlton CG. Lysophosphatidylcholine decreases locomotor activities and dopamine turnover rate in rats. Neurotoxicology. 2005 Jan; 26(1):27-38. PMID: 15527871.
      Citations: 7     Fields:    Translation:Animals
    26. Elsisi NS, Darling-Reed S, Lee EY, Oriaku ET, Soliman KF. Ibuprofen and apigenin induce apoptosis and cell cycle arrest in activated microglia. Neurosci Lett. 2005 Feb 28; 375(2):91-6. PMID: 15670648.
      Citations: 25     Fields:    Translation:AnimalsCells
    27. Lee ES, Chen H, Shepherd KR, Lamango NS, Soliman KF, Charlton CG. Inhibitory effects of lysophosphatidylcholine on the dopaminergic system. Neurochem Res. 2004 Jul; 29(7):1333-42. PMID: 15202762.
      Citations: 5     Fields:    Translation:AnimalsCells
    28. Lee ES, Chen H, Shepherd KR, Lamango NS, Soliman KF, Charlton CG. The inhibitory role of methylation on the binding characteristics of dopamine receptors and transporter. Neurosci Res. 2004 Mar; 48(3):335-44. PMID: 15154679.
      Citations: 7     Fields:    Translation:AnimalsCells
    Lee's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (163)
    Explore
    _
    Co-Authors (10)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

    For technical support please contact support