"Manganese Poisoning" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)
| Descriptor ID |
D020149
|
| MeSH Number(s) |
C10.720.475.500 C25.723.522.813
|
| Concept/Terms |
Manganese Poisoning- Manganese Poisoning
- Poisoning, Manganese
- Neurotoxicity Syndrome, Manganese
- Manganese Neurotoxicity Syndrome
- Manganese Neurotoxicity Syndromes
- Neurotoxicity Syndromes, Manganese
- Syndrome, Manganese Neurotoxicity
- Syndromes, Manganese Neurotoxicity
- Nervous System Diseases, Manganese-Induced
- Nervous System Diseases, Manganese Induced
- Nervous System Poisoning, Manganese
|
Below are MeSH descriptors whose meaning is more general than "Manganese Poisoning".
Below are MeSH descriptors whose meaning is more specific than "Manganese Poisoning".
This graph shows the total number of publications written about "Manganese Poisoning" by people in this website by year, and whether "Manganese Poisoning" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Manganese Poisoning" by people in Profiles.
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Pajarillo E, Kim S, Digman A, Dutton M, Son DS, Aschner M, Lee E. The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. J Biol Chem. 2023 07; 299(7):104879.
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Pajarillo E, Demayo M, Digman A, Nyarko-Danquah I, Son DS, Aschner M, Lee E. Deletion of RE1-silencing transcription factor in striatal astrocytes exacerbates manganese-induced neurotoxicity in mice. Glia. 2022 10; 70(10):1886-1901.
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Nyarko-Danquah I, Pajarillo E, Digman A, Soliman KFA, Aschner M, Lee E. Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms. Molecules. 2020 Dec 12; 25(24).
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Pajarillo E, Johnson J, Rizor A, Nyarko-Danquah I, Adinew G, Bornhorst J, Stiboller M, Schwerdtle T, Son DS, Aschner M, Lee E. Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity. J Biol Chem. 2020 11 13; 295(46):15662-15676.
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Pajarillo E, Johnson J, Kim J, Karki P, Son DS, Aschner M, Lee E. 17?-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity. Neurotoxicology. 2018 03; 65:280-288.
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Stephenson AP, Schneider JA, Nelson BC, Atha DH, Jain A, Soliman KF, Aschner M, Mazzio E, Renee Reams R. Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: attenuation of thymine base lesions by glutathione and N-acetylcysteine. Toxicol Lett. 2013 Apr 26; 218(3):299-307.
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Racette BA, Aschner M, Guilarte TR, Dydak U, Criswell SR, Zheng W. Pathophysiology of manganese-associated neurotoxicity. Neurotoxicology. 2012 Aug; 33(4):881-6.
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Garruto RM, Shankar SK, Yanagihara R, Salazar AM, Amyx HL, Gajdusek DC. Low-calcium, high-aluminum diet-induced motor neuron pathology in cynomolgus monkeys. Acta Neuropathol. 1989; 78(2):210-9.
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Yanagihara R. Heavy metals and essential minerals in motor neuron disease. Adv Neurol. 1982; 36:233-47.