"YY1 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed zinc finger-containing protein that acts both as a repressor and activator of transcription. It interacts with key regulatory proteins such as TATA-BINDING PROTEIN; TFIIB; and ADENOVIRUS E1A PROTEINS.
| Descriptor ID |
D050986
|
| MeSH Number(s) |
D12.776.260.235.875 D12.776.930.216.875
|
| Concept/Terms |
YY1 Transcription Factor- YY1 Transcription Factor
- Transcription Factor, YY1
- Yin-Yang-1 Protein
- Yin Yang 1 Protein
- Nuclear Matrix Protein 1
- Delta Transcription Factor
- Transcription Factor, Delta
- NF-D Nuclear Factor
- NF D Nuclear Factor
- Nuclear Factor, NF-D
- Transcriptional Repressor Protein YY1
|
Below are MeSH descriptors whose meaning is more general than "YY1 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "YY1 Transcription Factor".
This graph shows the total number of publications written about "YY1 Transcription Factor" by people in this website by year, and whether "YY1 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2014 | 3 | 0 | 3 |
| 2015 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 2 | 0 | 2 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "YY1 Transcription Factor" by people in Profiles.
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Pajarillo E, Nyarko-Danquah I, Digman A, Vied C, Son DS, Lee J, Aschner M, Lee E. Astrocytic Yin Yang 1 is critical for murine brain development and protection against apoptosis, oxidative stress, and inflammation. Glia. 2023 02; 71(2):450-466.
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Rizor A, Pajarillo E, Son DS, Aschner M, Lee E. Manganese phosphorylates Yin Yang 1 at serine residues to repress EAAT2 in human H4 astrocytes. Toxicol Lett. 2022 Feb 01; 355:41-46.
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Rizor A, Pajarillo E, Nyarko-Danquah I, Digman A, Mooneyham L, Son DS, Aschner M, Lee E. Manganese-induced reactive oxygen species activate I?B kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro. Neurotoxicology. 2021 09; 86:94-103.
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Pajarillo E, Johnson J, Rizor A, Nyarko-Danquah I, Adinew G, Bornhorst J, Stiboller M, Schwerdtle T, Son DS, Aschner M, Lee E. Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity. J Biol Chem. 2020 11 13; 295(46):15662-15676.
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Karki P, Kim C, Smith K, Son DS, Aschner M, Lee E. Transcriptional Regulation of the Astrocytic Excitatory Amino Acid Transporter 1 (EAAT1) via NF-?B and Yin Yang 1 (YY1). J Biol Chem. 2015 Sep 25; 290(39):23725-37.
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Karki P, Smith K, Johnson J, Aschner M, Lee E. Role of transcription factor yin yang 1 in manganese-induced reduction of astrocytic glutamate transporters: Putative mechanism for manganese-induced neurotoxicity. Neurochem Int. 2015 Sep; 88:53-9.
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Galloway NR, Diaz Osterman CJ, Reiber K, Jutzy JM, Li F, Sui G, Soto U, Wall NR. Yin Yang 1 regulates the transcriptional repression of Survivin. Biochem Biophys Res Commun. 2014 Feb 28; 445(1):208-13.
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Karki P, Webb A, Smith K, Johnson J, Lee K, Son DS, Aschner M, Lee E. Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes. Mol Cell Biol. 2014 Apr; 34(7):1280-9.
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He Y, Kim JY, Dupree J, Tewari A, Melendez-Vasquez C, Svaren J, Casaccia P. Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination. Nat Neurosci. 2010 Dec; 13(12):1472-80.
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Gordon SJ, Saleque S, Birshtein BK. Yin Yang 1 is a lipopolysaccharide-inducible activator of the murine 3' Igh enhancer, hs3. J Immunol. 2003 Jun 01; 170(11):5549-57.