Manganese

"Manganese" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)

Descriptor ID	D008345
MeSH Number(s)	D01.268.556.484 D01.268.956.374 D01.552.544.484
Concept/Terms	Manganese Manganese

Below are MeSH descriptors whose meaning is more general than "Manganese".

Chemicals and Drugs [D]
Inorganic Chemicals [D01]
Elements [D01.268]
Metals, Heavy [D01.268.556]
Manganese [D01.268.556.484]
Transition Elements [D01.268.956]
Manganese [D01.268.956.374]
Metals [D01.552]
Metals, Heavy [D01.552.544]
Manganese [D01.552.544.484]

Below are MeSH descriptors whose meaning is more specific than "Manganese".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Manganese" by people in this website by year, and whether "Manganese" was a major or minor topic of these publications.

Bar chart showing 69 publications over 24 distinct years, with a maximum of 6 publications in 2017 and 2023 and 2025

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	1	0	1
2000	0	2	2
2001	1	0	1
2002	1	2	3
2005	1	1	2
2006	1	1	2
2008	0	2	2
2009	0	1	1
2010	1	0	1
2011	1	0	1
2013	2	0	2
2014	1	3	4
2015	1	1	2
2016	3	1	4
2017	4	2	6
2018	3	0	3
2019	4	0	4
2020	3	1	4
2021	3	0	3
2022	0	4	4
2023	3	3	6
2024	1	3	4
2025	4	2	6

Below are the most recent publications written about "Manganese" by people in Profiles.

Digman A, Pajarillo E, Kim S, Ajayi I, Son DS, Aschner M, Lee E. Tamoxifen induces partial neuroprotection against manganese toxicity in the dopaminergic REST-deleted male mice. Neurotoxicology. 2025 Dec; 111:103330.

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Rodichkin AN, Brown AM, Devabathini P, McGlothan JL, Chen S, Pattammattel A, Chu YS, Lin T, Pontow DD, Abilmouna K, Kapoor R, Hardin SE, Pushkar Y, Sillitoe RV, Guilarte TR. Cerebellar dysfunction in a mouse model of childhood-onset manganese-induced dystonia parkinsonism. Neurobiol Dis. 2025 11; 216:107115.

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Kim S, Pajarillo E, Digman A, Ajayi I, Son DS, Aschner M, Lee E. CAD (Cath. a-Differentiated) Cells Produce Dopamine along with Dopamine-Synthesizing Enzymes. Neurochem Res. 2025 Jul 16; 50(4):233.

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Contreras EM, von Hippel FA, Cameron S, Del Simone K, Amir Abdul Nasir AF, Postlethwait J, Wilson R. Tissue tropism of toxic metals in northern quolls (Dasyurus hallucatus) and northern brown bandicoots (Isoodon macrourus) on Groote Eylandt, Australia. PLoS One. 2025; 20(6):epone.0322386.

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Digman A, Pajarillo E, Kim S, Ajayi I, Son DS, Aschner M, Lee E. Tamoxifen induces protection against manganese toxicity by REST upregulation via the ER-a/Wnt/?-catenin pathway in neuronal cells. J Biol Chem. 2025 06; 301(6):108529.

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Kim S, Pajarillo E, Digman A, Ajayi I, Son DS, Aschner M, Lee E. Role of dopaminergic RE1-silencing transcription factor (REST) in manganese-induced behavioral deficits and dysregulating dopaminergic and serotonergic neurotransmission in mice. Neurotoxicology. 2025 May; 108:57-68.

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Palai D, Roy T, De A, Mukherjee S, Bandyopadhyay S, Dhara S, Das S, Das K. Study on the Bioactivity Response of the Newly Developed Zn-Cu-Mn/Mg Alloys for Biodegradable Implant Application. ACS Biomater Sci Eng. 2024 10 14; 10(10):6167-6190.

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Pajarillo E, Kim S, Digman A, Ajayi I, Nyarko-Danquah I, Son DS, Aschner M, Lee E. Dopaminergic REST/NRSF is protective against manganese-induced neurotoxicity in mice. J Biol Chem. 2024 09; 300(9):107707.

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Nyarko-Danquah I, Pajarillo E, Kim S, Digman A, Multani HK, Ajayi I, Son DS, Aschner M, Lee E. Microglial Sp1 induced LRRK2 upregulation in response to manganese exposure, and 17?-estradiol afforded protection against this manganese toxicity. Neurotoxicology. 2024 Jul; 103:105-114.

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Schildroth S, Kordas K, White RF, Friedman A, Placidi D, Smith D, Lucchini RG, Wright RO, Horton M, Claus Henn B. An Industry-Relevant Metal Mixture, Iron Status, and Reported Attention-Related Behaviors in Italian Adolescents. Environ Health Perspect. 2024 Feb; 132(2):27008.

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