Up-Regulation

"Up-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Descriptor ID	D015854
MeSH Number(s)	G02.111.905 G05.308.850 G07.690.773.998
Concept/Terms	Up-Regulation Up-Regulation Up Regulation Upregulation Up-Regulation (Physiology) Receptor Up-Regulation Receptor Up-Regulation

Below are MeSH descriptors whose meaning is more general than "Up-Regulation".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Up-Regulation [G02.111.905]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Up-Regulation [G05.308.850]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacological Phenomena [G07.690.773]
Up-Regulation [G07.690.773.998]

Below are MeSH descriptors whose meaning is related to "Up-Regulation".

Below are MeSH descriptors whose meaning is more specific than "Up-Regulation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Up-Regulation" by people in this website by year, and whether "Up-Regulation" was a major or minor topic of these publications.

Bar chart showing 369 publications over 29 distinct years, with a maximum of 30 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	2	2
1996	0	2	2
1997	2	1	3
1998	0	3	3
1999	0	1	1
2001	0	1	1
2002	4	10	14
2003	3	16	19
2004	5	19	24
2005	3	17	20
2006	6	17	23
2007	2	14	16
2008	3	23	26
2009	2	16	18
2010	3	17	20
2011	4	26	30
2012	4	11	15
2013	4	14	18
2014	5	8	13
2015	2	16	18
2016	2	18	20
2017	2	12	14
2018	4	11	15
2019	0	8	8
2020	3	7	10
2021	3	7	10
2022	0	2	2
2023	0	1	1
2024	2	1	3

Below are the most recent publications written about "Up-Regulation" by people in Profiles.

Salian VS, Tang X, Thompson KJ, Curan GL, Lowe VJ, Li L, Kalari KR, Kandimalla KK. Molecular Mechanisms Underlying Amyloid Beta Peptide Mediated Upregulation of Vascular Cell Adhesion Molecule-1 in Alzheimer Disease. J Pharmacol Exp Ther. 2024 Nov 19; 391(3):430-440.

View in: PubMed
Ma C, Hoffmann FW, Shay AE, Koo I, Green KA, Green WR, Hoffmann PR. Upregulated selenoprotein I during lipopolysaccharide-induced B cell activation promotes lipidomic changes and is required for effective differentiation into IgM-secreting plasma B cells. J Leukoc Biol. 2024 Jun 28; 116(1):6-17.

View in: PubMed
Nyarko-Danquah I, Pajarillo E, Kim S, Digman A, Multani HK, Ajayi I, Son DS, Aschner M, Lee E. Microglial Sp1 induced LRRK2 upregulation in response to manganese exposure, and 17?-estradiol afforded protection against this manganese toxicity. Neurotoxicology. 2024 Jul; 103:105-114.

View in: PubMed
Kroll KW, Hueber B, Balachandran H, Afifi A, Manickam C, Nettere D, Pollara J, Hudson A, Woolley G, Ndhlovu LC, Reeves RK. FcaRI (CD89) is upregulated on subsets of mucosal and circulating NK cells and regulates IgA-class specific signaling and functions. Mucosal Immunol. 2024 Aug; 17(4):692-699.

View in: PubMed
Ouhara K, Takemura T, Taniguchi Y, Fujimori R, Tamura T, Akane Y, Matsuda S, Hamamoto Y, Shintani T, Kajiya M, Munenaga S, Iwata T, Fujita T, Mizuno N. Leucine-rich alpha-2-glycoprotein 1 affects bone destruction via IL-6 in mouse periodontitis model. Oral Dis. 2024 Nov; 30(8):5294-5304.

View in: PubMed
Singh A, Tripathi R, Gupta RK, Rashid R, Jha RK. Gonadotropin upregulates intraovarian calpains-1 and -2 during ovarian follicular recruitment in the SD rat model. Reprod Biol. 2024 Jun; 24(2):100862.

View in: PubMed
Meliambro K, Yang Y, de Cos M, Rodriguez Ballestas E, Malkin C, Haydak J, Lee JR, Salem F, Mariani LH, Gordon RE, Basgen JM, Wen HH, Fu J, Azeloglu EU, He JC, Wong JS, Campbell KN. KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression. JCI Insight. 2023 04 10; 8(7).

View in: PubMed
Adinew GM, Messeha SS, Taka E, Badisa RB, Soliman KFA. Anticancer Effects of Thymoquinone through the Antioxidant Activity, Upregulation of Nrf2, and Downregulation of PD-L1 in Triple-Negative Breast Cancer Cells. Nutrients. 2022 Nov 13; 14(22).

View in: PubMed
Adinew G, Messeha SS, Badisa R, Taka E, Soliman KFA. Thymoquinone Anticancer Effects Through the Upregulation of NRF2 and the Downregulation of PD-L1 in MDA-MB-231 Triple-Negative Breast Cancer Cells. FASEB J. 2022 05; 36 Suppl 1.

View in: PubMed
Chou WC, Tsai KL, Hsieh PL, Wu CH, Jou IM, Tu YK, Ma CH. Galectin-3 facilitates inflammation and apoptosis in chondrocytes through upregulation of the TLR-4-mediated oxidative stress pathway in TC28a2 human chondrocyte cells. Environ Toxicol. 2022 Mar; 37(3):478-488.

View in: PubMed

People

Explore

Similar Concepts

Top Journals