Dose-Response Relationship, Drug

"Dose-Response Relationship, Drug" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The relationship between the dose of an administered drug and the response of the organism to the drug.

Descriptor ID	D004305
MeSH Number(s)	G07.690.773.875 G07.690.936.500
Concept/Terms	Dose-Response Relationship, Drug Dose-Response Relationship, Drug Dose-Response Relationships, Drug Drug Dose-Response Relationship Drug Dose-Response Relationships Relationship, Drug Dose-Response Relationships, Drug Dose-Response Dose Response Relationship, Drug

Below are MeSH descriptors whose meaning is more general than "Dose-Response Relationship, Drug".

Biological Sciences [G]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacological Phenomena [G07.690.773]
Dose-Response Relationship, Drug [G07.690.773.875]
Toxicological Phenomena [G07.690.936]
Dose-Response Relationship, Drug [G07.690.936.500]

Below are MeSH descriptors whose meaning is related to "Dose-Response Relationship, Drug".

Below are MeSH descriptors whose meaning is more specific than "Dose-Response Relationship, Drug".

Dose-Response Relationship, Drug
Hormesis
Lethal Dose 50

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Dose-Response Relationship, Drug" by people in this website by year, and whether "Dose-Response Relationship, Drug" was a major or minor topic of these publications.

Bar chart showing 875 publications over 30 distinct years, with a maximum of 71 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	4	4
1997	0	2	2
1998	0	10	10
1999	0	10	10
2000	0	21	21
2001	0	26	26
2002	0	47	47
2003	0	42	42
2004	0	49	49
2005	0	71	71
2006	0	35	35
2007	0	37	37
2008	0	48	48
2009	0	40	40
2010	0	42	42
2011	1	36	37
2012	1	29	30
2013	0	41	41
2014	1	39	40
2015	0	53	53
2016	0	41	41
2017	1	38	39
2018	0	24	24
2019	0	14	14
2020	0	24	24
2021	0	15	15
2022	0	4	4
2024	0	7	7
2025	0	14	14
2026	0	8	8

Below are the most recent publications written about "Dose-Response Relationship, Drug" by people in Profiles.

Liu W, Mousa AAK, Dayer G, Hopkins AM, Campbell M, Mao Y, Jiang ZH, Lees SJ, Ramachandran R, Hou J. Urea-based lysophosphatidic acid receptor 1 antagonists as potential migrastatics for triple-negative breast cancer. Bioorg Chem. 2026 07 05; 175:109807.

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Ruiz K, Serrano-Arroyo L, Valent?n-Rosa V, Torres-Borges G, Vil? LM. Long-term outcomes of hydroxychloroquine dose reduction in Puerto Ricans with systemic lupus erythematosus: 6-year follow-up. Lupus Sci Med. 2026 Mar 24; 13(1).

View in: PubMed
Rasafar N, Sanchez-Michael LA, Torres A, Andujo LA, Gutierrez DA, Varela-Ramirez A, Aguilera RJ, Noveron JC. Novel anticancer alkyl pyridinium derivative exhibits antiproliferative activity via G0/G1 cell cycle arrest and apoptosis activation in triple-negative breast cancer cells. Bioorg Med Chem. 2026 Jun; 137:118638.

View in: PubMed
Del Valle MM, Colon EM, Kettimuthu K, Maner-Smith K, Olson JJ, Kucheryavykh LY. Window of opportunity study measuring defactinib and avutometinib delivery in glioblastomas. Cancer Chemother Pharmacol. 2026 Mar 06; 96(1).

View in: PubMed
Adeyinka OS, Metibemu DS, Hampton T, Ojobor JC, Crown O, Falode J, Barrera MD, Alem F, Narayanan A, Ogungbe IV. Broad-spectrum inhibitor of non-structural protein 2 protease shows therapeutic efficacy against Venezuelan equine encephalitis viral infection. Eur J Med Chem. 2026 Apr 15; 308:118696.

View in: PubMed
Parapini S, D'Alessandro S, Travaglione S, Paone S, Madera Cuevas IM, Dipol T, Zongo DWR, Figueroa V?zquez AM, Morsilli O, Fabbri A, Vlaar CP, Olivieri A. Design, synthesis and biological evaluation of Rac1-targeting carbazole-pyrimidines as host-directed antimalarials. Eur J Med Chem. 2026 Apr 15; 308:118690.

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Satti VR, Raza MS, Roshani K, Veeranki KC, Mondal T. Design and Synthesis of Novel Indazole-Sulfonamide Derivatives, Cytotoxicity, and Molecular Docking Insights. Chem Biodivers. 2026 Feb; 23(2):e03697.

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Reynaldo-Fernandez G, Rodriguez-Vera L, Amaro D, Soloz?bal J, Duconge J, Mangas-Sanjuan V, Troconiz IF, Azeredo FJ, Vozmediano V. Forecasting the Biological Effect of PEGylated-rHuEPO Candidates in Chronic Kidney Disease Patients using a Middle-out Translation Approach. Pharm Res. 2026 Feb; 43(2):381-393.

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Sharif NA, Kulkarni-Chitnis M, Okolie A, Chaudhry SD, Njie-Mbye YF, Ohia SE. Relaxation of Precontracted Ciliary Artery and Ciliary Muscle In Vitro by Kinin Peptides: Relevance to Retinal Blood Flow and Intraocular Pressure Regulation. J Ocul Pharmacol Ther. 2026 May; 42(4):251-260.

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El-Bayaa MN, Srour AM, Alanzy AL, Messaoudi S, Abd-Rabou AA, Saleh A, Saleh MGA, El-Sayed WA. Synthesis, anticancer activity and computational studies of new benzimidazole-triazole-pyridine glycoside conjugates. Future Med Chem. 2025 Dec; 17(24):2927-2943.

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