Dose-Response Relationship, Drug

"Dose-Response Relationship, Drug" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The relationship between the dose of an administered drug and the response of the organism to the drug.

Descriptor ID	D004305
MeSH Number(s)	G07.690.773.875 G07.690.936.500
Concept/Terms	Dose-Response Relationship, Drug Dose-Response Relationship, Drug Dose-Response Relationships, Drug Drug Dose-Response Relationship Drug Dose-Response Relationships Relationship, Drug Dose-Response Relationships, Drug Dose-Response Dose Response Relationship, Drug

Below are MeSH descriptors whose meaning is more general than "Dose-Response Relationship, Drug".

Biological Sciences [G]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacological Phenomena [G07.690.773]
Dose-Response Relationship, Drug [G07.690.773.875]
Toxicological Phenomena [G07.690.936]
Dose-Response Relationship, Drug [G07.690.936.500]

Below are MeSH descriptors whose meaning is related to "Dose-Response Relationship, Drug".

Below are MeSH descriptors whose meaning is more specific than "Dose-Response Relationship, Drug".

Dose-Response Relationship, Drug
Hormesis
Lethal Dose 50

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Dose-Response Relationship, Drug" by people in this website by year, and whether "Dose-Response Relationship, Drug" was a major or minor topic of these publications.

Bar chart showing 866 publications over 29 distinct years, with a maximum of 71 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	4	4
1997	0	3	3
1998	0	10	10
1999	0	10	10
2000	0	22	22
2001	0	26	26
2002	0	47	47
2003	0	43	43
2004	0	50	50
2005	0	71	71
2006	0	35	35
2007	0	38	38
2008	0	47	47
2009	0	40	40
2010	0	42	42
2011	1	36	37
2012	1	29	30
2013	0	41	41
2014	1	40	41
2015	0	53	53
2016	0	41	41
2017	1	38	39
2018	0	24	24
2019	0	14	14
2020	0	24	24
2021	0	15	15
2022	0	4	4
2024	0	7	7
2025	0	8	8

Below are the most recent publications written about "Dose-Response Relationship, Drug" by people in Profiles.

He AR, Smith CI, Cruz-Correa M, Chakraborty R, Zhang S, Sang S, Cheng G, Hecht SS, Bazzi LA, Kocherginsky M, Benante KA, Schering T, Richmond E, Rodriguez LM, Khan SA, Chung FL. A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver ?-OHPdG Levels. Cancer Prev Res (Phila). 2025 Oct 01; 18(10):635-646.

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Saleh M, Thabet MM, Kumari J, Mostafa YA, Sriram D, Suganuma K, Kandeel M, Abdu-Allah HHM. Design, Synthesis, Biological Evaluation, and In Silico Studies of New Nitazoxanide Derivatives: Toward Broad-Spectrum Antimicrobial Agents. Arch Pharm (Weinheim). 2025 Sep; 358(9):e70091.

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Beltran NM, Ramos J, Landavazo A, Blough BE, Serafine KM. Eating a high fat diet enhances sensitivity of rats to serotonin receptor agonists. Physiol Behav. 2025 Oct 15; 300:115031.

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Okpattah D, Karki A, Pillarsetty NVK, Harding WW. Synthesis and evaluation of aporphinoid 5-HT7AR ligands as inhibitors of PC3 prostate cancer cell growth. Bioorg Med Chem Lett. 2025 Dec 01; 128:130328.

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Rosenstock J, Hsia S, Nevarez Ruiz L, Eyde S, Cox D, Wu WS, Liu R, Li J, Fern?ndez Land? L, Denning M, Ludwig L, Chen Y. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. N Engl J Med. 2025 Sep 18; 393(11):1065-1076.

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Laffin LJ, Kopjar B, Melgaard C, Wolski K, Ibbitson J, Bhikam S, Weir MR, Ofili EO, Mehra R, Luther JM, Cohen DL, Sarraju A, Wilkinson MJ, Flack JM, Rodman D, Nissen SE. Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension. N Engl J Med. 2025 May 08; 392(18):1813-1823.

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Altinok F, Petrella M, Masi A, Borruto A, Ciccocioppo R, Ozturk Y. Exploring the supraspinal antihyperalgesic effects of levetiracetam in the rat model of chronic constriction injury. Can J Physiol Pharmacol. 2025 Jul 01; 103(7):244-256.

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Marshall-Lipiec SM, Ryan KL, Calderon ML, Rodriguez CM, Connor BS, Hinojosa-Laborde C, Klemcke HG. Effects of analgesic doses of opioids on cardiorespiratory responses and survival to hemorrhage and trauma in rats. J Appl Physiol (1985). 2025 Jul 01; 139(1):145-161.

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VanKoten HW, Pence BC, Klinkenberg JR, Das S, Patterson SE. Synthesis and evaluation of anti-Giardia activity of oseltamivir analogs. Bioorg Med Chem Lett. 2025 Feb 01; 116:130035.

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Bhalodiya SS, Parmar MP, Patel CD, Patel SG, Vala DP, Suresh N, Jayachandran B, Kumar Arumugam M, Narayan M, Patel HM. Acetic Acid-Driven One-Pot Synthesis of 4,7-dihydro-[1,2,3]thiadiazolo[5,4-b]pyridine-6-carboxamides and Pharmacological Evaluations. ChemMedChem. 2025 Jan 14; 20(2):e202400595.

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