"Drug Tolerance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
| Descriptor ID |
D004361
|
| MeSH Number(s) |
G07.690.773.992
|
| Concept/Terms |
Drug Tolerance- Drug Tolerance
- Drug Tolerances
- Tolerance, Drug
- Tolerances, Drug
|
Below are MeSH descriptors whose meaning is more general than "Drug Tolerance".
Below are MeSH descriptors whose meaning is more specific than "Drug Tolerance".
This graph shows the total number of publications written about "Drug Tolerance" by people in this website by year, and whether "Drug Tolerance" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 1 | 2 |
| 1995 | 0 | 2 | 2 |
| 1996 | 1 | 0 | 1 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 3 | 3 |
| 2001 | 1 | 0 | 1 |
| 2002 | 0 | 5 | 5 |
| 2003 | 1 | 1 | 2 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 1 | 2 |
| 2008 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2016 | 0 | 4 | 4 |
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Below are the most recent publications written about "Drug Tolerance" by people in Profiles.
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Khademi H, Kamangar F, Brennan P, Malekzadeh R. Opioid Therapy and its Side Effects: A Review. Arch Iran Med. 2016 Dec; 19(12):870-876.
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Vel?zquez-Marrero C, Burgos A, Garc?a JO, Palacio S, Marrero HG, Bernardo A, P?rez-Laspiur J, Rivera-Oliver M, Seale G, Treistman SN. Alcohol Regulates BK Surface Expression via Wnt/?-Catenin Signaling. J Neurosci. 2016 10 12; 36(41):10625-10639.
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Zhou L, Sun WL, Weierstall K, Minerly AC, Weiner J, Jenab S, Quinones-Jenab V. Sex differences in behavioral and PKA cascade responses to repeated cocaine administration. Psychopharmacology (Berl). 2016 Oct; 233(19-20):3527-36.
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Lutfy K, Parikh D, Lee DL, Liu Y, Ferrini MG, Hamid A, Friedman TC. Prohormone convertase 2 (PC2) null mice have increased mu opioid receptor levels accompanied by altered morphine-induced antinociception, tolerance and dependence. Neuroscience. 2016 08 04; 329:318-25.
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Pietrzykowski AZ, Ortiz-Miranda S, Knott TK, Custer E, Puig S, Lemos JR, Treistman SN. Molecular tolerance of voltage-gated calcium channels is evident after short exposures to alcohol in vasopressin-releasing nerve terminals. Alcohol Clin Exp Res. 2013 Jun; 37(6):933-40.
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Zhao L, Peng B, Hernandez-Viezcas JA, Rico C, Sun Y, Peralta-Videa JR, Tang X, Niu G, Jin L, Varela-Ramirez A, Zhang JY, Gardea-Torresdey JL. Stress response and tolerance of Zea mays to CeO2 nanoparticles: cross talk among H2O2, heat shock protein, and lipid peroxidation. ACS Nano. 2012 Nov 27; 6(11):9615-22.
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Treistman SN, Martin GE. BK Channels: mediators and models for alcohol tolerance. Trends Neurosci. 2009 Dec; 32(12):629-37.
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Martin GE, Hendrickson LM, Penta KL, Friesen RM, Pietrzykowski AZ, Tapper AR, Treistman SN. Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17543-8.
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Feinberg-Zadek PL, Martin G, Treistman SN. BK channel subunit composition modulates molecular tolerance to ethanol. Alcohol Clin Exp Res. 2008 Jul; 32(7):1207-16.
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Delgado-V?lez M, Lugo-Chinchilla A, Lizardo L, Morales I, Robles Y, Bruno N, Rodr?guez JW, R?os-Olivares E, Correa M, Renaud FL. Chronic exposure of human macrophages in vitro to morphine and methadone induces a putative tolerant/dependent state. J Neuroimmunol. 2008 May 30; 196(1-2):94-100.