Down-Regulation

"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Descriptor ID	D015536
MeSH Number(s)	G02.111.240 G05.308.200 G07.690.773.937
Concept/Terms	Down-Regulation Down-Regulation Down Regulation Downregulation Down-Regulation (Physiology) Receptor Down-Regulation Receptor Down-Regulation Down-Regulation, Receptor

Below are MeSH descriptors whose meaning is more general than "Down-Regulation".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Down-Regulation [G02.111.240]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Down-Regulation [G05.308.200]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacological Phenomena [G07.690.773]
Down-Regulation [G07.690.773.937]

Below are MeSH descriptors whose meaning is related to "Down-Regulation".

Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.

Bar chart showing 345 publications over 29 distinct years, with a maximum of 25 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	4	4
1998	0	5	5
1999	1	1	2
2000	0	5	5
2001	1	2	3
2002	1	9	10
2003	1	10	11
2004	1	10	11
2005	5	20	25
2006	3	19	22
2007	4	15	19
2008	1	13	14
2009	6	10	16
2010	5	17	22
2011	4	19	23
2012	2	17	19
2013	5	18	23
2014	3	11	14
2015	1	11	12
2016	2	17	19
2017	1	13	14
2018	2	7	9
2019	2	16	18
2020	1	7	8
2021	1	7	8
2022	0	5	5
2023	0	2	2
2025	0	1	1

Below are the most recent publications written about "Down-Regulation" by people in Profiles.

Armina-Rodriguez A, Vald?s Fernandez BN, Ocasio-Malav? C, Cantres Rosario YM, Carrasquillo Carri?n K, Mel?ndez LM, Roche Lima A, Tosado Rodriguez EL, Espino AM. Quantitative Proteomics Reveals Fh15 as an Antagonist of TLR4 Downregulating the Activation of NF-?B, Inducible Nitric Oxide, Phagosome Signaling Pathways, and Oxidative Stress of LPS-Stimulated Macrophages. Int J Mol Sci. 2025 Jul 18; 26(14).

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Sugawara S, Hueber B, Woolley G, Terry K, Kroll K, Manickam C, Ram DR, Ndhlovu LC, Goepfert P, Jost S, Reeves RK. Multiplex interrogation of the NK cell signalome reveals global downregulation of CD16 signaling during lentivirus infection through an IL-18/ADAM17-dependent mechanism. PLoS Pathog. 2023 09; 19(9):e1011629.

View in: PubMed
Simino LAP, Baqueiro MN, Panzarin C, Lopes PKF, G?is MM, Simabuco FM, Ign?cio-Souza LM, Milanski M, Ross MG, Desai M, Torsoni AS, Torsoni MA. Hypothalamic a7 nicotinic acetylcholine receptor (a7nAChR) is downregulated by TNFa-induced Let-7 overexpression driven by fatty acids. FASEB J. 2023 09; 37(9):e23120.

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Adinew GM, Messeha SS, Taka E, Badisa RB, Soliman KFA. Anticancer Effects of Thymoquinone through the Antioxidant Activity, Upregulation of Nrf2, and Downregulation of PD-L1 in Triple-Negative Breast Cancer Cells. Nutrients. 2022 Nov 13; 14(22).

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Liu X, Chipurupalli S, Jiang P, Tavasoli M, Yoo BH, McPhee M, Mazinani S, Francia G, Kerbel RS, Rosen KV. ErbB2/Her2-dependent downregulation of a cell death-promoting protein BLNK in breast cancer cells is required for 3D breast tumor growth. Cell Death Dis. 2022 08 06; 13(8):687.

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Ajibade T, Akinrinde A, Adetona M, Oyagbemi A, Adedapo A, Larbie C, Omobowale T, Ola-Davies O, Saba A, Adedapo A, Oguntibeju O, Yakubu M. Luteolin normalizes blood pressure via its antioxidant activity and down-regulation of renal Angiotensin II receptor and Mineralocorticoid receptor expressions in rats co-exposed to Diclofenac and sodium fluoride. Niger J Physiol Sci. 2022 Jun 30; 37(1):35-42.

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Gant DMA, Parris AB, Yang X. Metformin-induced downregulation of c-Met is a determinant of sensitivity in MDA-MB-468 breast cancer cells. Biochem Biophys Res Commun. 2022 07 12; 613:100-106.

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Adinew G, Messeha SS, Badisa R, Taka E, Soliman KFA. Thymoquinone Anticancer Effects Through the Upregulation of NRF2 and the Downregulation of PD-L1 in MDA-MB-231 Triple-Negative Breast Cancer Cells. FASEB J. 2022 05; 36 Suppl 1.

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Rivera-Ortiz J, Pla-Tenorio J, Cruz ML, Colon K, Perez-Morales J, Rodriguez JA, Martinez-Sicari J, Noel RJ. Blockade of beta adrenergic receptors protects the blood brain barrier and reduces systemic pathology caused by HIV-1 Nef protein. PLoS One. 2021; 16(11):e0259446.

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Chuang TD, Quintanilla D, Boos D, Khorram O. Long Noncoding RNA MIAT Modulates the Extracellular Matrix Deposition in Leiomyomas by Sponging MiR-29 Family. Endocrinology. 2021 11 01; 162(11).

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