Protein Binding

"Protein Binding" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Descriptor ID	D011485
MeSH Number(s)	G02.111.679 G03.808
Concept/Terms	Protein Binding Protein Binding Binding, Protein Plasma Protein Binding Capacity Plasma Protein Binding Capacity

Below are MeSH descriptors whose meaning is more general than "Protein Binding".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Protein Binding [G02.111.679]
Metabolism [G03]
Protein Binding [G03.808]

Below are MeSH descriptors whose meaning is related to "Protein Binding".

Below are MeSH descriptors whose meaning is more specific than "Protein Binding".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Binding" by people in this website by year, and whether "Protein Binding" was a major or minor topic of these publications.

Bar chart showing 897 publications over 30 distinct years, with a maximum of 60 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	9	9
1997	0	4	4
1998	0	4	4
1999	1	6	7
2000	0	14	14
2001	0	15	15
2002	0	37	37
2003	0	35	35
2004	0	44	44
2005	2	49	51
2006	0	34	34
2007	0	38	38
2008	0	32	32
2009	1	39	40
2010	0	39	39
2011	0	60	60
2012	0	55	55
2013	0	45	45
2014	0	36	36
2015	0	54	54
2016	0	30	30
2017	1	37	38
2018	0	33	33
2019	0	27	27
2020	0	28	28
2021	0	27	27
2022	0	9	9
2023	1	6	7
2024	6	18	24
2025	0	21	21

Below are the most recent publications written about "Protein Binding" by people in Profiles.

Verma S, Singh A, Ramirez Orozco RS, Vukovic L, Narayan M, Kumar P. Structural Insights into PFAS-?-Lactoglobulin-Binding Mechanism Mediating PFAS Toxicity. Biochemistry. 2026 03 03; 65(5):532-544.

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Castillo O, Rivera LM, Albalawi A, Brancaleon L. Photosensitization activity of normal and Hyperporphyirins self-assembled with recombinant albumin: Consequences for the development of engineered photoreceptor proteins. J Photochem Photobiol B. 2026 Mar; 276:113386.

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Yao Q, Mahase V, Hou W, Cruz-Cosme R, Tang Q, Teng S. Computational and experimental identification of potential neutralizing peptides derived from human ACE2 against SARS-CoV-2 infection. J Virol. 2026 03 24; 100(3):e0146825.

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Shatarupa A, Brown D, Olinares PDB, Chase J, Isiorho E, Chait BT, Jeruzalmi D. Distinct quaternary states, intermediates, and autoinhibition during loading of the DnaB-replicative helicase by the phage ?P helicase loader. Nucleic Acids Res. 2025 Nov 26; 53(22).

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Wang M, Du G, Yongo-Luwawa C, Lu A, Kinrade B, Munro K, Klose KE, Lubell WD, Davies P, Guo S. Peptide-based ligand antagonists block a Vibrio cholerae adhesin. FEBS Lett. 2026 Mar; 600(5):631-643.

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Liu M, Wan S, Guo S, Liu J, Li W, Wang L, Li F, Zhang J, Liu X, Liu D, Yao X, Gao J, Ruan K, He W. Fragment-Based Discovery of a Small-Molecule RhoGDI2 Ligand, HR3119, that Inhibits Cancer Cell Migration. ACS Chem Biol. 2025 11 21; 20(11):2584-2592.

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Guo W, Dong R, Okedigba AO, Sanchez JE, Agarkova IV, Abisamra EM, Jelinsky A, Riekhof W, Noor L, Dunigan DD, Van Etten JL, Capelluto DGS, Xiao C, Li L. Membrane Composition Modulates Vp54 Binding: A Combined Experimental and Computational Study. Pathogens. 2025 Oct 03; 14(10).

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Huang MB, Tiwari PB, ?ren A, Shelton MN, Brena D, Wu JY, Khan MB, Powell MD, Stiles JK, Johnson EL, Yan F, Yang L, Bond VC. Investigating SMR Peptide Interactions with Breast Cancer-Associated Proteins. Int J Mol Sci. 2025 Sep 11; 26(18).

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Okeoma BC, Kaddour H, Naushad W, Paromov V, Chaudhary A, Noghero A, Stapleton JT, Okeoma CM. Identification of proteins in semen-derived extracellular vesicles that bind to Tat and NF-?B and that may impair HIV replication. Sci Signal. 2025 Sep 09; 18(903):eado9243.

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Hui B, Bu Z, Cheng X. Role of vinculin in the structural dynamics of cadherin-catenin complexes and its implications for F-actin binding. Protein Sci. 2025 Sep; 34(9):e70259.

View in: PubMed

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