Protein Binding

"Protein Binding" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Descriptor ID	D011485
MeSH Number(s)	G02.111.679 G03.808
Concept/Terms	Protein Binding Protein Binding Binding, Protein Plasma Protein Binding Capacity Plasma Protein Binding Capacity

Below are MeSH descriptors whose meaning is more general than "Protein Binding".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Protein Binding [G02.111.679]
Metabolism [G03]
Protein Binding [G03.808]

Below are MeSH descriptors whose meaning is related to "Protein Binding".

Below are MeSH descriptors whose meaning is more specific than "Protein Binding".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Binding" by people in this website by year, and whether "Protein Binding" was a major or minor topic of these publications.

Bar chart showing 897 publications over 30 distinct years, with a maximum of 60 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	9	9
1997	0	4	4
1998	0	4	4
1999	1	6	7
2000	0	14	14
2001	0	15	15
2002	0	37	37
2003	0	35	35
2004	0	44	44
2005	2	49	51
2006	0	34	34
2007	0	38	38
2008	0	32	32
2009	1	39	40
2010	0	39	39
2011	0	60	60
2012	0	55	55
2013	0	45	45
2014	0	36	36
2015	0	54	54
2016	0	30	30
2017	1	37	38
2018	0	33	33
2019	0	27	27
2020	0	28	28
2021	0	27	27
2022	0	9	9
2023	1	6	7
2024	6	18	24
2025	0	21	21

Below are the most recent publications written about "Protein Binding" by people in Profiles.

Okeoma BC, Kaddour H, Naushad W, Paromov V, Chaudhary A, Noghero A, Stapleton JT, Okeoma CM. Identification of proteins in semen-derived extracellular vesicles that bind to Tat and NF-?B and that may impair HIV replication. Sci Signal. 2025 Sep 09; 18(903):eado9243.

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Hui B, Bu Z, Cheng X. Role of vinculin in the structural dynamics of cadherin-catenin complexes and its implications for F-actin binding. Protein Sci. 2025 Sep; 34(9):e70259.

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Du K, Zhang X, Qin Y, Ma H, Bing C, Deng S, Chen Y, Qin J, Chang S, Xiao S, Peng L, Xie X, Feng X, Fu X, Wei Y, Fan X, Ashktorab H, Smoot D, Jin Z, Peng Y. MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKa in gastric adenocarcinoma. Cell Death Dis. 2025 Sep 01; 16(1):667.

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Sharma S, Vishwakarma J, Czub J, Sappati S, Gavvala K. Elucidation of the Synergistic Interaction Between Bilirubin and Casein Protein: An Integrated Spectroscopy and Computational Approach. Biomacromolecules. 2025 Aug 11; 26(8):5298-5309.

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Maniaci B, Mealka M, Bobkov AA, Stec B, Huxford T, Love JJ. Incorporating Metal-Ligand and Salt-Bridge Interactions in the Design of Protein Heterodimers. Biochemistry. 2025 Aug 05; 64(15):3237-3247.

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Ellison V, Polotskaia A, Xiao G, Leybengrub P, Lee R, Qiu W, Hendrickson RC, Hu W, Bargonetti J. A cancer persistent DNA repair circuit driven by MDM2, MDM4 (MDMX), and mutant p53 for recruitment of MDC1 and 53BP1 on chromatin. Nucleic Acids Res. 2025 Jul 08; 53(13).

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Aubee JI, Nurse J, Lewis D, Tai CH, Thompson KM. NsrR Represses sE-Dependent Small RNAs and Interacts with RpoE via a Noncanonical Mechanism in Escherichia coli. Int J Mol Sci. 2025 Jun 30; 26(13).

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Fu W, Wang X, Rafiq M, Shao H, Wang C, Wang D, Tao C, Fu C, Zieger B, Liu X, Yao X, Zhang L. Multivalent interactions of Septin 6 promote the establishment of epithelial cell polarity. J Mol Cell Biol. 2025 Jun 28; 17(1).

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Gao N, Mazzoletti D, Peng A, Olinares PDB, Morrone C, Garavaglia A, Gouda N, Tsoy S, Mendoza A, Chowdhury A, Cerullo A, Bhavsar H, Rossi F, Rizzi M, Chait BT, Miggiano R, Jeruzalmi D. DnaB and DciA: mechanisms of helicase loading and translocation on ssDNA. Nucleic Acids Res. 2025 Jun 20; 53(12).

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van Heesch T, Sharma S, van Erp B, Ort?z APA, Dame RT, Vreede J, Gavvala K. Adaptation of DNA to Protein Binding Revealed by Spectroscopy and Molecular Simulation. J Phys Chem B. 2025 Jun 12; 129(23):5653-5663.

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