Signal Transduction

"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Descriptor ID	D015398
MeSH Number(s)	G02.111.820 G04.835
Concept/Terms	Signal Transduction Signal Transduction Signal Transductions Transduction, Signal Transductions, Signal Signal Transduction Systems Signal Transduction System System, Signal Transduction Systems, Signal Transduction Signal Pathways Signal Pathways Pathway, Signal Pathways, Signal Signal Pathway Signal Transduction Pathways Signal Transduction Pathways Pathway, Signal Transduction Pathways, Signal Transduction Signal Transduction Pathway Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transductions Signal Transduction, Receptor-Mediated Signal Transductions, Receptor-Mediated Receptor Mediated Signal Transduction

Below are MeSH descriptors whose meaning is more general than "Signal Transduction".

Below are MeSH descriptors whose meaning is related to "Signal Transduction".

Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.

Bar chart showing 1678 publications over 30 distinct years, with a maximum of 101 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	2	4	6
1997	4	3	7
1998	6	9	15
1999	6	11	17
2000	5	9	14
2001	3	7	10
2002	15	25	40
2003	16	30	46
2004	15	42	57
2005	24	35	59
2006	25	29	54
2007	25	34	59
2008	22	38	60
2009	21	46	67
2010	18	39	57
2011	23	72	95
2012	20	62	82
2013	26	62	88
2014	28	70	98
2015	25	74	99
2016	16	66	82
2017	27	74	101
2018	20	77	97
2019	24	70	94
2020	28	49	77
2021	10	49	59
2022	3	20	23
2023	4	26	30
2024	21	31	52
2025	3	30	33

Below are the most recent publications written about "Signal Transduction" by people in Profiles.

Gonz?lez-Ch?vez SA, Loya-Rivera M, Nair S, Prieto-Carrasco R, Chaparro-Barrera E, Ruizesparza-Hinojos DA, Roy S, Pacheco-Tena C. IL-33 links inflammation and bone remodeling in experimental spondyloarthritis and human joint biopsies. Cytokine. 2025 Dec; 196:157031.

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Cabrera-Fuentes HA, Ruiz-Meana M, Barreto G, Serebruany VL, S?nchez-Vega JT, P?rez-Campos E, Kostin S, B?ning A, Jarqu?n Gonz?lez EE, Al-Suhaimi EA, Rodriguez-Montesinos J, Inserte J, Pedretti S, Yap J, Irei J, Sedding DG, Lecour S, Liehn EA, Garcia-Dorado D, Hausenloy DJ, Boisvert WA, Preissner KT. Extracellular RNA drives TNF-a/TNF-receptor-1 mediated cardiac ischemia/reperfusion injury: Mechanistic insights and therapeutic potential of RNase1. Pharmacol Res. 2025 Nov; 221:107944.

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Wang C, Zhou J, Li T, Du S, Urushidani T, Wang D, Chen Y, Mullen M, Cao X, Cheng SY, Ding X, Yang F, Yao X. Akt-elicited phosphorylation of Acapin steers cell migration. J Mol Cell Biol. 2025 Sep 10; 17(3).

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Sidhu RS, Guo S, Wang G, Liu M. Role of Notch and its oncogenic signaling crosstalk in glioma and glioma stem cells. Gene. 2025 Oct 15; 969:149761.

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Du K, Zhang X, Qin Y, Ma H, Bing C, Deng S, Chen Y, Qin J, Chang S, Xiao S, Peng L, Xie X, Feng X, Fu X, Wei Y, Fan X, Ashktorab H, Smoot D, Jin Z, Peng Y. MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKa in gastric adenocarcinoma. Cell Death Dis. 2025 Sep 01; 16(1):667.

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Cheng J, Cheng M, Sinha S, Cely I, Gladkikh S, Han MT, Zhang G, Zhou Z, Chugh R, Ahn IS, Diamante G, Wang YC, Wang Z, Bennett BJ, Cai H, Allayee H, Hazen SL, Lusis AJ, Shih DM, Yang X. Trimethylamine-N-Oxide Affects Cell Type-Specific Pathways and Networks in Mouse Aorta to Promote Atherosclerotic Plaque Vulnerability. Arterioscler Thromb Vasc Biol. 2025 Oct; 45(10):1784-1798.

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Armina-Rodriguez A, Vald?s Fernandez BN, Ocasio-Malav? C, Cantres Rosario YM, Carrasquillo Carri?n K, Mel?ndez LM, Roche Lima A, Tosado Rodriguez EL, Espino AM. Quantitative Proteomics Reveals Fh15 as an Antagonist of TLR4 Downregulating the Activation of NF-?B, Inducible Nitric Oxide, Phagosome Signaling Pathways, and Oxidative Stress of LPS-Stimulated Macrophages. Int J Mol Sci. 2025 Jul 18; 26(14).

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Ofosu-Boateng M, Choi S, Kim S, Twum E, Nnamani DO, Gebreyesus LH, Niture S, Yadak N, Kumar D, Gonzalez FJ, Liangpunsakul S, Cui JY, Gyamfi MA. Human PXR Signaling Exacerbates Ethanol-induced Liver Injury in Females: Evidence From Mouse Models and Human Alcohol-associated Liver Disease Cohorts. Cell Mol Gastroenterol Hepatol. 2025; 19(11):101589.

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Wamba BEN, Mondal T, Freenor V F, Shaheed M, Pang O, Bedinger D, Legembre P, Devel L, Bhatnagar S, Leiserowitz GS, Tushir-Singh J. Evolutionary regulation of human Fas ligand (CD95L) by plasmin in solid cancer immunotherapy. Nat Commun. 2025 Jul 01; 16(1):5748.

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Muralidharan J, Eswaran M, Bae S, Singh S, Mir H. Elevated CCL20 and IL-10 enhance 5-fluorouracil tolerance in colon cancer. Biomed Pharmacother. 2025 Aug; 189:118258.

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