Substrate Specificity

"Substrate Specificity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

Descriptor ID	D013379
MeSH Number(s)	G02.111.835
Concept/Terms	Substrate Specificity Substrate Specificity Specificities, Substrate Specificity, Substrate Substrate Specificities

Below are MeSH descriptors whose meaning is more general than "Substrate Specificity".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Substrate Specificity [G02.111.835]

Below are MeSH descriptors whose meaning is related to "Substrate Specificity".

Below are MeSH descriptors whose meaning is more specific than "Substrate Specificity".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Substrate Specificity" by people in this website by year, and whether "Substrate Specificity" was a major or minor topic of these publications.

Bar chart showing 175 publications over 28 distinct years, with a maximum of 18 publications in 2006

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1995	2	2
1996	6	6
1997	3	3
1998	4	4
2000	2	2
2001	3	3
2002	5	5
2003	9	9
2004	9	9
2005	14	14
2006	18	18
2007	5	5
2008	12	12
2009	10	10
2010	10	10
2011	8	8
2012	7	7
2013	6	6
2014	6	6
2015	1	1
2016	5	5
2017	9	9
2018	4	4
2019	5	5
2020	4	4
2021	5	5
2023	2	2
2024	1	1

Below are the most recent publications written about "Substrate Specificity" by people in Profiles.

Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C. Mechanism of ?-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase. Nat Commun. 2024 Apr 26; 15(1):3558.

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Calhoun JC, Damania B, Griffith JD, Costantini LM. Electron microscopy mapping of the DNA-binding sites of monomeric, dimeric, and multimeric KSHV RTA protein. J Virol. 2023 10 31; 97(10):e0063723.

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Toro TB, Bornes KE, Watt TJ. Lysine Deacetylase Substrate Selectivity: Distinct Interaction Surfaces Drive Positive and Negative Selection for Residues Following Acetyllysine. Biochemistry. 2023 05 02; 62(9):1464-1483.

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Hargrove TY, Wawrzak Z, Rachakonda G, Nes WD, Villalta F, Guengerich FP, Lepesheva GI. Relaxed Substrate Requirements of Sterol 14a-Demethylase from Naegleria fowleri Are Accompanied by Resistance to Inhibition. J Med Chem. 2021 12 09; 64(23):17511-17522.

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Toro TB, Swanier JS, Bezue JA, Broussard CG, Watt TJ. Lysine Deacetylase Substrate Selectivity: A Dynamic Ionic Interaction Specific to KDAC8. Biochemistry. 2021 08 24; 60(33):2524-2536.

View in: PubMed
Luo QJ, Zhang J, Li P, Wang Q, Zhang Y, Roy-Chaudhuri B, Xu J, Kay MA, Zhang QC. RNA structure probing reveals the structural basis of Dicer binding and cleavage. Nat Commun. 2021 06 07; 12(1):3397.

View in: PubMed
Smiley-Moreno E, Smith D, Yu JJ, Cao P, Arulanandam BP, Chambers JP. Biochemical characterization of a recombinant acid phosphatase from Acinetobacter baumannii. PLoS One. 2021; 16(6):e0252377.

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Lopez A, Havranek B, Papadantonakis GA, Islam SM. In silico screening and molecular dynamics simulation of deleterious PAH mutations responsible for phenylketonuria genetic disorder. Proteins. 2021 06; 89(6):683-696.

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Chen X, Liao S, Makaros Y, Guo Q, Zhu Z, Krizelman R, Dahan K, Tu X, Yao X, Koren I, Xu C. Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase. Nat Chem Biol. 2021 03; 17(3):254-262.

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Hall JL, Sohail A, Cabrita EJ, Macdonald C, Stockner T, Sitte HH, Angulo J, MacMillan F. Saturation transfer difference NMR on the integral trimeric membrane transport protein GltPh determines cooperative substrate binding. Sci Rep. 2020 10 05; 10(1):16483.

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