"Polyadenylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.
| Descriptor ID |
D026723
|
| MeSH Number(s) |
G02.111.760.225.710 G03.839.225.710 G05.308.700.225.710
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polyadenylation".
Below are MeSH descriptors whose meaning is more specific than "Polyadenylation".
This graph shows the total number of publications written about "Polyadenylation" by people in this website by year, and whether "Polyadenylation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2008 | 2 | 2 | 4 |
| 2010 | 3 | 0 | 3 |
| 2011 | 1 | 2 | 3 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 4 | 6 | 10 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 2 | 3 |
| 2018 | 2 | 0 | 2 |
| 2019 | 5 | 1 | 6 |
| 2020 | 2 | 0 | 2 |
| 2021 | 2 | 3 | 5 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 2 | 3 |
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Below are the most recent publications written about "Polyadenylation" by people in Profiles.
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Murphy MR, Ramadei A, Doymaz A, Varriano S, Natelson DM, Yu A, Aktas S, Mazzeo M, Mazzeo M, Zakusilo G, Kleiman FE. Long non-coding RNA generated from CDKN1A gene by alternative polyadenylation regulates p21 expression during DNA damage response. Nucleic Acids Res. 2023 Nov 27; 51(21):11911-11926.
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Hao S, Zhang L, Zhao D, Zhou J, Ye C, Qu H, Li QQ. Inhibitor AN3661 reveals biological functions of Arabidopsis CLEAVAGE and POLYADENYLATION SPECIFICITY FACTOR 73. Plant Physiol. 2023 08 31; 193(1):537-554.
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Ma H, Lin J, Mei F, Mao H, Li QQ. Differential alternative polyadenylation of homoeologous genes of allohexaploid wheat ABD subgenomes during drought stress response. Plant J. 2023 05; 114(3):499-518.
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Lin J, Li QQ. Coupling epigenetics and RNA polyadenylation: missing links. Trends Plant Sci. 2023 02; 28(2):223-234.
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Ye C, Zhao D, Ye W, Wu X, Ji G, Li QQ, Lin J. QuantifyPoly(A): reshaping alternative polyadenylation landscapes of eukaryotes with weighted density peak clustering. Brief Bioinform. 2021 11 05; 22(6).
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You LY, Lin J, Xu HW, Chen CX, Chen JY, Zhang J, Zhang J, Li YX, Ye C, Zhang H, Jiang J, Zhu JK, Li QQ, Duan CG. Intragenic heterochromatin-mediated alternative polyadenylation modulates miRNA and pollen development in rice. New Phytol. 2021 10; 232(2):835-852.
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Lin J, Ye C, Li QQ. QPAT-seq, a rapid and deduplicatable method for quantification of poly(A) site usages. Methods Enzymol. 2021; 655:73-83.
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Murphy MR, Doymaz A, Kleiman FE. Poly(A) tail dynamics: Measuring polyadenylation, deadenylation and poly(A) tail length. Methods Enzymol. 2021; 655:265-290.
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Zhang YZ, Lin J, Ren Z, Chen CX, Miki D, Xie SS, Zhang J, Chang YN, Jiang J, Yan J, Li QQ, Zhu JK, Duan CG. Genome-wide distribution and functions of the AAE complex in epigenetic regulation in Arabidopsis. J Integr Plant Biol. 2021 Apr; 63(4):707-722.
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Lin J, Hung FY, Ye C, Hong L, Shih YH, Wu K, Li QQ. HDA6-dependent histone deacetylation regulates mRNA polyadenylation in Arabidopsis. Genome Res. 2020 10; 30(10):1407-1417.