Alkylation

"Alkylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.

Descriptor ID	D000478
MeSH Number(s)	G02.111.035 G02.607.094 G03.059
Concept/Terms	Alkylation Alkylation Alkylations

Below are MeSH descriptors whose meaning is more general than "Alkylation".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Alkylation [G02.111.035]
Organic Chemistry Phenomena [G02.607]
Alkylation [G02.607.094]
Metabolism [G03]
Alkylation [G03.059]

Below are MeSH descriptors whose meaning is related to "Alkylation".

Below are MeSH descriptors whose meaning is more specific than "Alkylation".

Alkylation
Methylation

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Alkylation" by people in this website by year, and whether "Alkylation" was a major or minor topic of these publications.

Bar chart showing 11 publications over 10 distinct years, with a maximum of 2 publications in 2005

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1994	1	1
1998	1	1
1999	1	1
2000	1	1
2001	1	1
2005	2	2
2008	1	1
2009	1	1
2011	1	1
2020	1	1

Below are the most recent publications written about "Alkylation" by people in Profiles.

Franke AA, Li X, Dabalos C, Lai JF. Improved oxytocin analysis from human serum and urine by orbitrap ESI-LC-HRAM-MS. Drug Test Anal. 2020 Jun; 12(6):846-852.

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Das S, Das U, Varela-Ram?rez A, Lema C, Aguilera RJ, Balzarini J, De Clercq E, Dimmock SG, Gorecki DK, Dimmock JR. Bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides: a novel class of potent cytotoxins. ChemMedChem. 2011 Oct 04; 6(10):1892-9.

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Acevedo-Torres K, Fonseca-Williams S, Ayala-Torres S, Torres-Ramos CA. Requirement of the Saccharomyces cerevisiae APN1 gene for the repair of mitochondrial DNA alkylation damage. Environ Mol Mutagen. 2009 May; 50(4):317-27.

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Penick MA, Mahindaratne MP, Gutierrez RD, Smith TD, Tiekink ER, Negrete GR. Tandem Friedel-Crafts annulation to novel perylene analogues. J Org Chem. 2008 Aug 15; 73(16):6378-81.

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Berger GO, Tius MA. Terpestacin core structure. control of stereochemistry. Org Lett. 2005 Oct 27; 7(22):5011-3.

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Yuan J, Kinter M, McGeehan J, Perry G, Kneale G, Gambetti P, Zou WQ. Concealment of epitope by reduction and alkylation in prion protein. Biochem Biophys Res Commun. 2005 Jan 21; 326(3):652-9.

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Carballeira NM, Betancourt JE, Orellano EA, Gonz?lez FA. Total synthesis and biological evaluation of (5Z,9Z)-5,9-hexadecadienoic acid, an inhibitor of human topoisomerase I. J Nat Prod. 2002 Nov; 65(11):1715-8.

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Zhao H, Hans S, Cheng X, Mootoo DR. Allylated monosaccharides as precursors in triple reductive amination strategies: synthesis of castanospermine and swainsonine. J Org Chem. 2001 Mar 09; 66(5):1761-7.

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Noel RJ, Reznikoff WS. Structural studies of lacUV5-RNA polymerase interactions in vitro. Ethylation interference and missing nucleoside analysis. J Biol Chem. 2000 Mar 17; 275(11):7708-12.

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Ablordeppey SY, Fan P, Clark AM, Nimrod A. Probing the N-5 region of the indoloquinoline alkaloid, cryptolepine for anticryptococcal activity. Bioorg Med Chem. 1999 Feb; 7(2):343-9.

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