Allosteric Regulation

"Allosteric Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.

Descriptor ID	D000494
MeSH Number(s)	G02.111.044
Concept/Terms	Allosteric Regulation Allosteric Regulation Regulation, Allosteric Allosteric Regulations Regulations, Allosteric

Below are MeSH descriptors whose meaning is more general than "Allosteric Regulation".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Allosteric Regulation [G02.111.044]

Below are MeSH descriptors whose meaning is related to "Allosteric Regulation".

Below are MeSH descriptors whose meaning is more specific than "Allosteric Regulation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Allosteric Regulation" by people in this website by year, and whether "Allosteric Regulation" was a major or minor topic of these publications.

Bar chart showing 22 publications over 16 distinct years, with a maximum of 3 publications in 2013 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2003	0	1	1
2004	0	1	1
2007	1	0	1
2009	0	1	1
2010	0	2	2
2011	0	2	2
2013	0	3	3
2014	0	1	1
2015	0	1	1
2016	0	3	3
2017	0	1	1
2018	1	0	1
2020	0	1	1
2023	0	1	1
2025	0	1	1

Below are the most recent publications written about "Allosteric Regulation" by people in Profiles.

Daniels MH, Castro J, Lee YT, Gotur D, Knockenhauer KE, Grigoriu S, Lockbaum GJ, Cheong JE, Lu C, Brennan D, Buker SM, Liu J, Yao S, Sparling BA, Sickmier EA, Ribich S, Blakemore SJ, Silver SJ, Boriack-Sjodin PA, Duncan KW, Copeland RA. Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9. J Med Chem. 2025 May 08; 68(9):9537-9554.

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Piserchio A, Long KJ, Browning LS, Bohanon AL, Isiorho EA, Dalby KN, Ghose R. ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by?calmodulin. Proc Natl Acad Sci U S A. 2023 04 25; 120(17):e2300902120.

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Schnatz PJ, Brisendine JM, Laing CC, Everson BH, French CA, Molinaro PM, Koder RL. Designing heterotropically activated allosteric conformational switches using supercharging. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5291-5297.

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Jagla CAD, Scott CE, Tang Y, Qiao C, Mateo-Semidey GE, Yudowski GA, Lu D, Kendall DA. Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate ?-Arrestin-Dependent Responses. Mol Pharmacol. 2019 01; 95(1):1-10.

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Wichern F, Jensen MM, Christensen DZ, Mikkelsen JD, Gondr?-Lewis MC, Thomsen MS. Perinatal nicotine treatment induces transient increases in NACHO protein levels in the rat frontal cortex. Neuroscience. 2017 03 27; 346:278-283.

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Callaway DJ, Bu Z. Visualizing the nanoscale: protein internal dynamics and neutron spin echo spectroscopy. Curr Opin Struct Biol. 2017 02; 42:1-5.

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Gaieb Z, Lo DD, Morikis D. Molecular Mechanism of Biased Ligand Conformational Changes in CC Chemokine Receptor 7. J Chem Inf Model. 2016 09 26; 56(9):1808-22.

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Selvam C, Thilagavathi R, Narasimhan B, Kumar P, Jordan BC, Ranganna K. Computer-aided design of negative allosteric modulators of metabotropic glutamate receptor 5 (mGluR5): Comparative molecular field analysis of aryl ether derivatives. Bioorg Med Chem Lett. 2016 Feb 15; 26(4):1140-4.

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Callaway DJ, Bu Z. Essential Strategies for Revealing Nanoscale Protein Dynamics by Neutron Spin Echo Spectroscopy. Methods Enzymol. 2016; 566:253-70.

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Jehle K, Cato L, Neeb A, Muhle-Goll C, Jung N, Smith EW, Buzon V, Carb? LR, Est?banez-Perpi?? E, Schmitz K, Fruk L, Luy B, Chen Y, Cox MB, Br?se S, Brown M, Cato AC. Coregulator control of androgen receptor action by a novel nuclear receptor-binding motif. J Biol Chem. 2014 Mar 28; 289(13):8839-51.

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