Structure-Activity Relationship

"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Descriptor ID	D013329
MeSH Number(s)	G02.111.830 G07.690.773.997
Concept/Terms	Structure-Activity Relationship Structure-Activity Relationship Relationship, Structure-Activity Relationships, Structure-Activity Structure Activity Relationship Structure-Activity Relationships

Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Structure-Activity Relationship [G02.111.830]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacological Phenomena [G07.690.773]
Structure-Activity Relationship [G07.690.773.997]

Below are MeSH descriptors whose meaning is related to "Structure-Activity Relationship".

Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".

Structure-Activity Relationship
Quantitative Structure-Activity Relationship

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.

Bar chart showing 374 publications over 30 distinct years, with a maximum of 29 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	6	6
1997	0	2	2
1998	0	4	4
1999	0	2	2
2000	0	5	5
2001	0	4	4
2002	0	11	11
2003	0	9	9
2004	0	13	13
2005	0	8	8
2006	0	12	12
2007	1	13	14
2008	0	14	14
2009	0	10	10
2010	0	20	20
2011	0	17	17
2012	0	17	17
2013	0	21	21
2014	2	18	20
2015	0	29	29
2016	1	26	27
2017	0	18	18
2018	0	13	13
2019	0	12	12
2020	0	26	26
2021	0	9	9
2022	0	4	4
2023	0	6	6
2024	0	15	15
2025	0	6	6

Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.

Liu W, Mousa AAK, Dayer G, Hopkins AM, Campbell M, Mao Y, Jiang ZH, Lees SJ, Ramachandran R, Hou J. Urea-based lysophosphatidic acid receptor 1 antagonists as potential migrastatics for triple-negative breast cancer. Bioorg Chem. 2026 07 05; 175:109807.

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Rasafar N, Sanchez-Michael LA, Torres A, Andujo LA, Gutierrez DA, Varela-Ramirez A, Aguilera RJ, Noveron JC. Novel anticancer alkyl pyridinium derivative exhibits antiproliferative activity via G0/G1 cell cycle arrest and apoptosis activation in triple-negative breast cancer cells. Bioorg Med Chem. 2026 Jun; 137:118638.

View in: PubMed
Adeyinka OS, Metibemu DS, Hampton T, Ojobor JC, Crown O, Falode J, Barrera MD, Alem F, Narayanan A, Ogungbe IV. Broad-spectrum inhibitor of non-structural protein 2 protease shows therapeutic efficacy against Venezuelan equine encephalitis viral infection. Eur J Med Chem. 2026 Apr 15; 308:118696.

View in: PubMed
Parapini S, D'Alessandro S, Travaglione S, Paone S, Madera Cuevas IM, Dipol T, Zongo DWR, Figueroa V?zquez AM, Morsilli O, Fabbri A, Vlaar CP, Olivieri A. Design, synthesis and biological evaluation of Rac1-targeting carbazole-pyrimidines as host-directed antimalarials. Eur J Med Chem. 2026 Apr 15; 308:118690.

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Afosah DK, Mottamal M, Kar S, Smith ELS, Selico-Dunn AC, Ahmed SA, Al-Horani RA. New Non-Saccharide Heparin Mimetics as Inhibitors of Cathepsin G. Chem Biol Drug Des. 2026 Feb; 107(2):e70271.

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Satti VR, Raza MS, Roshani K, Veeranki KC, Mondal T. Design and Synthesis of Novel Indazole-Sulfonamide Derivatives, Cytotoxicity, and Molecular Docking Insights. Chem Biodivers. 2026 Feb; 23(2):e03697.

View in: PubMed
El-Bayaa MN, Srour AM, Alanzy AL, Messaoudi S, Abd-Rabou AA, Saleh A, Saleh MGA, El-Sayed WA. Synthesis, anticancer activity and computational studies of new benzimidazole-triazole-pyridine glycoside conjugates. Future Med Chem. 2025 Dec; 17(24):2927-2943.

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Leas DA, H?berli C, White KL, Shackleford DM, Jones JO, Campbell M, Wu J, Kaushik D, Dong Y, Wallick AI, Charman SA, Keiser J, Davis PH, Vennerstrom JL. Structure-Activity Relationship of Antischistosomal Aryl Hydantoin (AR102). J Med Chem. 2025 Oct 23; 68(20):21725-21738.

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Kassem AF, Mounier MM, Abdelglil MI, Abdelwahed S, El-Rashedy AA, Saleh A, Saleh MGA, Srour AM. Dual Anticancer and COX-2 Inhibitory Activity of Tailored Paracetamol-Alkanesulfonate Conjugates: A Promising Therapeutic Approach. Arch Pharm (Weinheim). 2025 Oct; 358(10):e70125.

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Patra S, Namballa HK, Gudipally AR, Xie L, Xie L, Harding WW. Discovery of a selective a2C-AR scaffold from a molecular hybridization approach. Bioorg Med Chem. 2025 Dec 15; 131:118424.

View in: PubMed

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