Structure-Activity Relationship

"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Descriptor ID	D013329
MeSH Number(s)	G02.111.830 G07.690.773.997
Concept/Terms	Structure-Activity Relationship Structure-Activity Relationship Relationship, Structure-Activity Relationships, Structure-Activity Structure Activity Relationship Structure-Activity Relationships

Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Structure-Activity Relationship [G02.111.830]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacological Phenomena [G07.690.773]
Structure-Activity Relationship [G07.690.773.997]

Below are MeSH descriptors whose meaning is related to "Structure-Activity Relationship".

Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".

Structure-Activity Relationship
Quantitative Structure-Activity Relationship

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.

Bar chart showing 322 publications over 31 distinct years, with a maximum of 23 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	4	4
1995	0	4	4
1996	0	6	6
1997	0	2	2
1998	0	4	4
1999	0	2	2
2000	0	5	5
2001	0	4	4
2002	0	11	11
2003	0	10	10
2004	0	12	12
2005	0	7	7
2006	0	11	11
2007	1	13	14
2008	0	14	14
2009	0	11	11
2010	0	21	21
2011	0	16	16
2012	0	16	16
2013	0	21	21
2014	2	16	18
2015	0	23	23
2016	1	18	19
2017	0	13	13
2018	0	11	11
2019	0	10	10
2020	0	17	17
2021	0	7	7
2022	0	1	1
2023	0	5	5
2024	0	3	3

Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.

Wang S, Wang J, Lu X, Liu M, Liu Y, Li M, Kong X, Wu L, Guan Q, Zhang W. Design, synthesis and biological evaluation of novel tubulin-targeting agents with a dual-mechanism for polymerization inhibition and protein degradation. Eur J Med Chem. 2024 Jun 05; 272:116458.

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Liang Z, Candib A, Soriano-Castell D, Fischer W, Finley K, Maher P. Fragment-based drug discovery and biological evaluation of novel cannabinol-based inhibitors of oxytosis/ferroptosis for neurological disorders. Redox Biol. 2024 Jun; 72:103138.

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Upadhyay DB, Mokariya JA, Patel PJ, Patel SG, Das A, Nandi A, Nogales J, More N, Kumar A, Rajani DP, Narayan M, Kumar J, Banerjee S, Sahoo SK, Patel HM. Indole clubbed 2,4-thiazolidinedione linked 1,2,3-triazole as a potent antimalarial and antibacterial agent against drug-resistant strain and molecular modeling studies. Arch Pharm (Weinheim). 2024 Apr; 357(4):e2300673.

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Swain RM, Sanchez A, Gutierrez DA, Varela-Ramirez A, Aguilera RJ. Thiophene derivative inflicts cytotoxicity via an intrinsic apoptotic pathway on human acute lymphoblastic leukemia cells. PLoS One. 2023; 18(12):e0295441.

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Mito S, Cheng B, Garcia BA, Yee Ooi X, Gonzalez D, Ruiz TC, Elisarraras FX, Tsin A. SAR study of niclosamide derivatives for neuroprotective function in SH-SY5Y neuroblastoma. Bioorg Med Chem Lett. 2023 11 15; 96:129498.

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Giri R, Namballa HK, Emogaje V, Harding WW. Structure-Activity Relationship Studies on 6-Chloro-1-phenylbenzazepines Leads to the Identification of a New Dopamine D1 Receptor Antagonist. Molecules. 2023 Aug 11; 28(16).

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Norseeda K, Bin Aziz Pavel F, Rutherford JT, Meer HN, Dureja C, Hurdle JG, Hevener KE, Sun D. Synthesis and evaluation of phenylimidazole FabK inhibitors as new Anti-C. Difficile agents. Bioorg Med Chem. 2023 06 06; 88-89:117330.

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Piserchio A, Isiorho EA, Dalby KN, Ghose R. Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor. J Biol Chem. 2023 06; 299(6):104813.

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Ferraris D, Lapidus R, Truong P, Bollino D, Carter-Cooper B, Lee M, Chang E, LaRossa-Garcia M, Dash S, Gartenhaus R, Choi EY, Kipe O, Lam V, Mason K, Palmer R, Williams E, Ambulos N, Kamangar F, Zhang Y, Kapadia B, Jing Y, Emadi A. Pre-Clinical Activity of Amino-Alcohol Dimeric Naphthoquinones as Potential Therapeutics for Acute Myeloid Leukemia. Anticancer Agents Med Chem. 2022; 22(2):239-253.

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Domzalski A, Margent L, Vigo V, Dewan F, Pilarsetty NVK, Xu Y, Kawamura A. Unambiguous Stereochemical Assignment of Cyclo(Phe-Pro), Cyclo(Leu-Pro), and Cyclo(Val-Pro) by Electronic Circular Dichroic Spectroscopy. Molecules. 2021 Oct 02; 26(19).

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