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Dianqing Sun, PhD

Title
Faculty RankAssociate Professor
InstitutionUniversity of Hawaii
DepartmentPharmaceutical Sciences
Address200 W. Kawili Street
Honolulu HI 96720
Phone8089332960
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    Other Positions
    TitleAssociate Professor
    InstitutionUniversity of Hawaii Cancer Center
    DepartmentNatural Products & Experimental Therapeutics


    Collapse Biography 
    Collapse awards and honors
    2005GRC on Combinatorial Chemistry Graduate Fellowship Award
    2011Excellence in Teaching Award for Pharmaceutical Sciences, University of Hawaii at Hilo
    2012Faculty Travel Grant, ACS Division of Organic Chemistry
    2014GRC on New Antibacterial Discovery & Development PUI fund award

    Collapse Overview 
    Collapse overview
    Research in Dianqing Sun's laboratory focuses on the design and synthesis of novel small molecule and natural product based anti-infective and anti-cancer agents. The chemical approaches include classical organic synthesis, parallel and high-throughput chemistry, solid-phase organic synthesis, followed by traditional medicinal chemistry optimization of the emerging lead compounds.
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Norseeda K, Bin Aziz Pavel F, Rutherford JT, Meer HN, Dureja C, Hurdle JG, Hevener KE, Sun D. Synthesis and evaluation of phenylimidazole FabK inhibitors as new Anti-C. Difficile agents. Bioorg Med Chem. 2023 06 06; 88-89:117330. PMID: 37224699.
      Citations: 2     Fields:    
    2. Sun D, Kinney J, Hintz A, Beck M, Chen AMH. Advancing Pharmacy Education by Moving From Sequenced "Integration" to True Curricular Integration. Am J Pharm Educ. 2023 06; 87(6):100056. PMID: 37316122.
      Citations: 1     Fields:    Translation:Humans
    3. Sun D. Recent Advances in Macrocyclic Drugs and Microwave-Assisted and/or Solid-Supported Synthesis of Macrocycles. Molecules. 2022 Feb 02; 27(3). PMID: 35164274.
      Citations: 7     Fields:    
    4. Prior AM, Sun D. Solid-Phase Synthesis of Wollamide Cyclohexapeptide Analogs. Methods Mol Biol. 2020; 2103:175-187. PMID: 31879925.
      Citations: 1     Fields:    Translation:Cells
    5. Prior AM, Sun D. Total synthesis of diazaquinomycins H and J using double Knorr cyclization in the presence of triisopropylsilane. RSC Adv. 2019 Jan 14; 9(4):1759-1771. PMID: 35516148.
      Citations:    
    6. Zhang M, Park EJ, Kondratyuk TP, Pezzuto JM, Sun D. Synthesis and Structure-Activity Relationships of Tetrahydro-?-carboline Derivatives as Anticancer and Cancer-chemopreventive Agents. Anticancer Res. 2018 Aug; 38(8):4425-4433. PMID: 30061206.
      Citations: 2     Fields:    Translation:AnimalsCells
    7. Prior AM, Hori T, Fishman A, Sun D. Recent Reports of Solid-Phase Cyclohexapeptide Synthesis and Applications. Molecules. 2018 Jun 18; 23(6). PMID: 29912160.
      Citations: 2     Fields:    Translation:Cells
    8. Yu X, Zhang M, Annamalai T, Bansod P, Narula G, Tse-Dinh YC, Sun D. Synthesis, evaluation, and CoMFA study of fluoroquinophenoxazine derivatives as bacterial topoisomerase IA inhibitors. Eur J Med Chem. 2017 Jan 05; 125:515-527. PMID: 27689733.
      Citations: 4     Fields:    Translation:HumansCells
    9. Chai X, Youn UJ, Sun D, Dai J, Williams P, Kondratyuk TP, Borris RP, Davies J, Villanueva IG, Pezzuto JM, Chang LC. Herbicidin congeners, undecose nucleosides from an organic extract of Streptomyces sp. L-9-10. J Nat Prod. 2014 Feb 28; 77(2):227-33. PMID: 24533857.
      Citations: 5     Fields:    Translation:HumansCells
    10. Lee RE, Hurdle JG, Liu J, Bruhn DF, Matt T, Scherman MS, Vaddady PK, Zheng Z, Qi J, Akbergenov R, Das S, Madhura DB, Rathi C, Trivedi A, Villellas C, Lee RB, Waidyarachchi SL, Sun D, McNeil MR, Ainsa JA, Boshoff HI, Gonzalez-Juarrero M, Meibohm B, B?ttger EC, Lenaerts AJ. Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux. Nat Med. 2014 Feb; 20(2):152-158. PMID: 24464186.
      Citations: 73     Fields:    Translation:AnimalsCells
    11. Tsutsumi LS, Owusu YB, Hurdle JG, Sun D. Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review. Curr Top Med Chem. 2014; 14(1):152-75. PMID: 24236721.
      Citations: 18     Fields:    Translation:HumansCells
    12. Park EJ, Shen L, Sun D, Pezzuto JM. Inhibitory effect of a callophycin A derivative on iNOS expression via inhibition of Akt in lipopolysaccharide-stimulated RAW 264.7 cells. J Nat Prod. 2014 Mar 28; 77(3):527-35. PMID: 24299616.
      Citations: 3     Fields:    Translation:AnimalsCells
    13. Lin H, Annamalai T, Bansod P, Tse-Dinh YC, Sun D. Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors. Medchemcomm. 2013 Dec 01; 4(12). PMID: 24363888.
      Citations:    
    14. Yu X, Sun D. Macrocyclic drugs and synthetic methodologies toward macrocycles. Molecules. 2013 May 24; 18(6):6230-68. PMID: 23708234.
      Citations: 54     Fields:    Translation:Cells
    15. Shen L, Maddox MM, Adhikari S, Bruhn DF, Kumar M, Lee RE, Hurdle JG, Lee RE, Sun D. Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents. J Antibiot (Tokyo). 2013 Jun; 66(6):319-25. PMID: 23549356.
      Citations: 8     Fields:    Translation:Cells
    16. Lin H, Sun D. RECENT SYNTHETIC DEVELOPMENTS AND APPLICATIONS OF THE ULLMANN REACTION. A REVIEW. Org Prep Proced Int. 2013; 45(5). PMID: 24223434.
      Citations:    
    17. Yu X, Park EJ, Kondratyuk TP, Pezzuto JM, Sun D. Synthesis of 2-arylindole derivatives and evaluation as nitric oxide synthase and NF?B inhibitors. Org Biomol Chem. 2012 Nov 28; 10(44):8835-47. PMID: 23044819.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    18. Pieroni M, Girmay S, Sun D, Sahu R, Tekwani BL, Tan GT. Synthesis and structure-activity relationships of lansine analogues as antileishmanial agents. ChemMedChem. 2012 Nov; 7(11):1895-900. PMID: 22987791.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    19. Sun D, Hurdle JG, Lee R, Lee R, Cushman M, Pezzuto JM. Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead. ChemMedChem. 2012 Sep; 7(9):1541-5. PMID: 22847956.
      Citations: 14     Fields:    Translation:HumansCells
    20. Shen L, Simmons CJ, Sun D. Microwave-assisted synthesis of macrocycles via intramolecular and/or bimolecular Ullmann coupling. Tetrahedron Lett. 2012 Aug 08; 53(32):4173-4178. PMID: 23049146.
      Citations: 7     Fields:    
    21. Shen L, Park EJ, Kondratyuk TP, Guendisch D, Marler L, Pezzuto JM, Wright AD, Sun D. Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents. Bioorg Med Chem. 2011 Nov 01; 19(21):6182-95. PMID: 21978950.
      Citations: 6     Fields:    Translation:HumansCells
    22. Shen L, Sun D. Total synthesis and structural revision of engelhardione. Tetrahedron Lett. 2011 Aug 31; 52(35):4570-4574. PMID: 21927512.
      Citations: 9     Fields:    
    23. Brown JR, North EJ, Hurdle JG, Morisseau C, Scarborough JS, Sun D, Kordul?kov? J, Scherman MS, Jones V, Grzegorzewicz A, Crew RM, Jackson M, McNeil MR, Lee RE. The structure-activity relationship of urea derivatives as anti-tuberculosis agents. Bioorg Med Chem. 2011 Sep 15; 19(18):5585-95. PMID: 21840723.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    24. Sivendran S, Jones V, Sun D, Wang Y, Grzegorzewicz AE, Scherman MS, Napper AD, McCammon JA, Lee RE, Diamond SL, McNeil M. Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC). Bioorg Med Chem. 2010 Jan 15; 18(2):896-908. PMID: 19969466.
      Citations: 18     Fields:    Translation:HumansCells
    25. Sun D, Xu H, Wijerathna SR, Dealwis C, Lee RE. Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors. ChemMedChem. 2009 Oct; 4(10):1649-56. PMID: 19681093.
      Citations: 1     Fields:    Translation:Animals
    26. Hurdle JG, Yendapally R, Sun D, Lee RE. Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections. Antimicrob Agents Chemother. 2009 Sep; 53(9):4028-31. PMID: 19581456.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    27. Sun D, Scherman MS, Jones V, Hurdle JG, Woolhiser LK, Knudson SE, Lenaerts AJ, Slayden RA, McNeil MR, Lee RE. Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity. Bioorg Med Chem. 2009 May 15; 17(10):3588-94. PMID: 19386501.
      Citations: 7     Fields:    Translation:AnimalsCells
    28. Sun D, Lee RB, Tangallapally RP, Lee RE. Synthesis, optimization and structure-activity relationships of 3,5-disubstituted isoxazolines as new anti-tuberculosis agents. Eur J Med Chem. 2009 Feb; 44(2):460-72. PMID: 18524421.
      Citations: 7     Fields:    Translation:Cells
    29. Sun D, Jones V, Carson EI, Lee RE, Scherman MS, McNeil MR, Lee RE. Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6899-904. PMID: 17962016.
      Citations: 5     Fields:    Translation:Cells
    30. Tangallapally RP, Sun D, Budha N, Lee RE, Lenaerts AJ, Meibohm B, Lee RE. Discovery of novel isoxazolines as anti-tuberculosis agents. Bioorg Med Chem Lett. 2007 Dec 01; 17(23):6638-42. PMID: 17937983.
      Citations: 18     Fields:    Translation:AnimalsCells
    31. Sun D, Lee RE. Solid-phase synthesis of a thymidinyl dipeptide urea library. J Comb Chem. 2007 May-Jun; 9(3):370-85. PMID: 17417912.
      Citations: 5     Fields:    Translation:Cells
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