RCMI Coordinating Center (RCMI CC) Header Logo

Leng Chee Chang, PhD

Title
Faculty RankAssociate Professor
InstitutionUniversity of Hawaii at Manoa
DepartmentPharmaceutical Sciences
AddressThe Daniel K. Inouye College of Pharmacy
University of Hawaii at Hilo
34 Rainbow Drive
Hilo HI 96720
Phone8089332951; 808-981-8018
Fax8089332974
vCardDownload vCard
    Other Positions
    TitleAssociate Member
    InstitutionUniversity of Hawaii Cancer Center


    Collapse Biography 
    Collapse awards and honors
    1997Van Doren Scholar Award, College of Pharmacy, University of Illinois at Chicago, Chicago, IL
    1998Kilmer Prize, American Society of Pharmacognosy, Orlando, Florida
    2004Travel Grant for Active Members, ASP, Phoenix, Arizona
    2006D. John Faulkner Travel Award, American Society of Pharmacognosy, Arlington, Virginia
    2008Faculty Travel Award, Office of Research, University of Hawaii Hilo
    2011Excellence in Teaching Award for Pharmaceutical Sciences, College of Pharmacy, U Hawaii at Hilo
    2013Excellence in Teaching Award for Pharmaceutical Sciences, College of Pharmacy, U Hawaii at Hilo

    Collapse Overview 
    Collapse overview
    Leng Chee Chang, Assistant Professor of the Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawaii at Hilo, HI, USA, investigates new cancer chemotherapeutic and cancer chemopreventative agents from plant and microbial natural products. She earned her Ph.D. degree in Natural Products at the University of Illinois at Chicago. During her Ph.D. study, she worked on a research project investigating new cancer chemopreventive agents which were derived from plants. This project was funded as Program Project (P01) grant entitled “Natural Inhibitors of Carcinogenesis” by the National Cancer Institute to Professors A. D. Kinghorn and John M. Pezzuto. She received further training as an Intramural Research Training Award fellow with Dr. Carole A. Bewley, LBC, NIDDK, NIH. Thirteen promising bioactive marine natural products were isolated during her fellowship, nine having novel structures.

    Her current research has focused on the evaluation of natural products as cancer chemopreventive and chemotherapeutic agents, where promising bioactive natural products may serve as lead compounds for drug design. She have established collaborations with Director of Natural Products and Therapeutic Program, UH Cancer Center, Dr. James Turkson, in the area of STAT3 as cancer therapeutic target; Dean College of Pharmacy, Dr. John M. Pezzuto, in the area of plant-derived cancer chemopreventative agents.

    She has more than fifteen years of experience as a researcher in natural products chemistry. Her research results have appeared in: Journal of Natural Products, Organic Letters, Planta Medica, Tetrahedron, and Bioorganic Medicinal Chemistry Letters.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Li XJ, Chang L, Mi Y, Zhang G, Zhu SS, Zhang YX, Wang HY, Lu YS, Ping YX, Zheng PY, Xue X. Integrated-omics analysis defines subtypes of hepatocellular carcinoma based on circadian rhythm. J Integr Med. 2025 Jul; 23(4):445-456. PMID: 40581550.
      Citations:    Fields:    Translation:Humans
    2. Liu Q, Liu X, Chang L, Ji H, Sun H, Yan Y, Xu J, Wang L. Optimizing HIV testing: Comparing diagnostic signatures and assay performance in ART-treated and general screening populations. Clin Chim Acta. 2025 Mar 15; 570:120207. PMID: 39988301.
      Citations:    Fields:    Translation:HumansPHPublic Health
    3. Gong L, Chang L, Chen S, Wei X, Du H, Cheng J, Chen X, Yuan Z, Zhao P, Geng M, Yang H, Cai K, Dai L. Multifunctional injectable hydrogel with self-supplied H2S release and bacterial inhibition for the wound healing with enhanced macrophages polarization via interfering with PI3K/Akt pathway. Biomaterials. 2025 Jul; 318:123144. PMID: 39892016.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Gao Z, Su Y, Jiao G, Lou Z, Chang L, Yu R, Xu C, Han X, Wang Z, Li J, Deng XW, He H. Cell-Type Specific miRNA Regulatory Network Responses to ABA Stress Revealed by Time Series Transcriptional Atlases in Arabidopsis. Adv Sci (Weinh). 2025 Mar; 12(9):e2415083. PMID: 39792694.
      Citations: 2     Fields:    Translation:AnimalsCells
    5. Wang X, Liu H, Wang J, Chang L, Cai J, Wei Z, Pan J, Gu X, Li WL, Li J. Enzyme Tunnel Dynamics and Catalytic Mechanism of Norcoclaurine Synthase: Insights from a Combined LiGaMD and DFT Study. J Phys Chem B. 2024 Oct 03; 128(39):9385-9395. PMID: 39315758.
      Citations: 2     Fields:    Translation:Cells
    6. Ambalavanan A, Chang L, Choi J, Zhang Y, Stickley SA, Fang ZY, Miliku K, Robertson B, Yonemitsu C, Turvey SE, Mandhane PJ, Simons E, Moraes TJ, Anand SS, Par? G, Williams JE, Murdoch BM, Otoo GE, Mbugua S, Kamau-Mbuthia EW, Kamundia EW, Gindola DK, Rodriguez JM, Pareja RG, Sellen DW, Moore SE, Prentice AM, Foster JA, Kvist LJ, Neibergs HL, McGuire MA, McGuire MK, Meehan CL, Sears MR, Subbarao P, Azad MB, Bode L, Duan Q. Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children. Nat Commun. 2024 09 04; 15(1):7735. PMID: 39232002.
      Citations: 7     Fields:    Translation:HumansCells
    7. Wang J, Hou Q, Qu J, Huo X, Li H, Feng Y, Wang Q, Chang L, Xu C. Polyhedral magnetic nanoparticles induce apoptosis in gastric cancer stem cells and suppressing tumor growth through magnetic force generation. J Control Release. 2024 Sep; 373:370-384. PMID: 39032573.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    8. Sun M, Chang L, He L, Wang L, Jiang Z, Si Y, Yu J, Ma Y. Combining single-cell profiling and functional analysis explores the role of pseudogenes in human early embryonic development. J Genet Genomics. 2024 Nov; 51(11):1173-1186. PMID: 39032861.
      Citations:    Fields:    Translation:HumansCells
    9. Zhou Z, Zhang G, Wang Z, Xu Y, Qin H, Zhang H, Zhang P, Li Z, Xu S, Tan X, Zeng Y, Yu F, Zhu S, Chang L, Zheng Y, Han X. Molecular subtypes of ischemic heart disease based on circadian rhythm. Sci Rep. 2024 06 19; 14(1):14155. PMID: 38898215.
      Citations: 1     Fields:    Translation:Humans
    10. Zhu HT, Luo J, Peng Y, Cheng XF, Wu SZ, Zhao YD, Chang L, Sun ZJ, Dong DL. Nitazoxanide protects against experimental ulcerative colitis through improving intestinal barrier and inhibiting inflammation. Chem Biol Interact. 2024 May 25; 395:111013. PMID: 38663798.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    11. Chang L, Goff HD, Ding C, Liu Q, Zhao S, Tao T, Lu R, Gao Y, Wu H, Guo L. Enhanced hypoglycemic effects of konjac glucomannan combined with Polygonatum cyrtonema Hua polysaccharide in complete nutritional liquid diet fed type 2 diabetes mice. Int J Biol Macromol. 2024 May; 266(Pt 1):131121. PMID: 38522692.
      Citations: 5     Fields:    Translation:Animals
    12. Gao Z, Su Y, Chang L, Jiao G, Ou Y, Yang M, Xu C, Liu P, Wang Z, Qi Z, Liu W, Sun L, He G, Deng XW, He H. Increased long-distance and homo-trans interactions related to H3K27me3 in Arabidopsis hybrids. J Integr Plant Biol. 2024 Feb; 66(2):208-227. PMID: 38326968.
      Citations:    Fields:    Translation:AnimalsCells
    13. Zhou F, Tan P, Liu S, Chang L, Yang J, Sun M, Guo Y, Si Y, Wang D, Yu J, Ma Y. Subcellular RNA distribution and its change during human embryonic stem cell differentiation. Stem Cell Reports. 2024 01 09; 19(1):126-140. PMID: 38134924.
      Citations: 1     Fields:    Translation:HumansCells
    14. Yan XZ, Ma L, Li XF, Chang L, Liu QZ, Song CF, Zhao JY, Qie XT, Deng CP, Wang CZ, Hao C. Identification and evaluation of cruciferous plant volatiles attractive to Plutella xylostella L. (Lepidoptera: Plutellidae). Pest Manag Sci. 2023 Dec; 79(12):5270-5282. PMID: 37602963.
      Citations: 4     Fields:    Translation:Animals
    15. Chang L, Zhang A, Liu W, Cao P, Dong L, Gao X. Calycosin inhibits hepatocyte apoptosis in acute liver failure by suppressing the TLR4/NF-?B pathway: An in vitro study. Immun Inflamm Dis. 2023 07; 11(7):e935. PMID: 37506138.
      Citations: 1     Fields:    Translation:HumansCells
    16. Xiao Y, Yan Y, Chang L, Ji H, Sun H, Song S, Feng K, Nuermaimaiti A, Lu Z, Wang L. CDK4/6 inhibitor palbociclib promotes SARS-CoV-2?cell entry by down-regulating SKP2 dependent ACE2 degradation. Antiviral Res. 2023 04; 212:105558. PMID: 36806814.
      Citations: 8     Fields:    Translation:HumansCells
    17. Sun H, Chang L, Yan Y, Ji H, Jiang X, Song S, Xiao Y, Lu Z, Wang L. Naturally occurring pre-S mutations promote occult HBV infection by affecting pre-S2/S promoter activity. Antiviral Res. 2022 12; 208:105448. PMID: 36257516.
      Citations: 6     Fields:    Translation:HumansCells
    18. Xu J, Wang D, Ma H, Zhai X, Huo Y, Ren Y, Li W, Chang L, Lu D, Guo Y, Si Y, Gao Y, Wang X, Ma Y, Wang F, Yu J. KHSRP combines transcriptional and posttranscriptional mechanisms to regulate monocytic differentiation. Blood Sci. 2022 Jul; 4(3):103-115. PMID: 36518592.
      Citations:    
    19. Chang L, Zhao L, Xiao Y, Xu T, Chen L, Cai Y, Dong X, Wang C, Xiao X, Ren L, Wang L. Serosurvey for SARS-CoV-2 among blood donors in Wuhan, China from September to December 2019. Protein Cell. 2023 01; 14(1):28-36. PMID: 36726761.
      Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
    20. Chang L, Hou W, Zhao L, Zhang Y, Wang Y, Wu L, Xu T, Wang L, Wang J, Ma J, Wang L, Zhao J, Xu J, Dong J, Yan Y, Yang R, Li Y, Guo F, Cheng W, Su Y, Zeng J, Han W, Cheng T, Zhang J, Yuan Q, Xia N, Wang L. The prevalence of antibodies to SARS-CoV-2 among blood donors in China. Nat Commun. 2021 03 02; 12(1):1383. PMID: 33654063.
      Citations: 42     Fields:    Translation:HumansCells
    21. Yan Y, Chang L, Luo W, Liu J, Guo F, Wang L. Comparison of Seven Commercial Severe Acute Respiratory Syndrome Coronavirus 2 Nucleic Acid Detection Reagents with Pseudovirus as Quality Control Material. J Mol Diagn. 2021 03; 23(3):300-309. PMID: 33383210.
      Citations: 9     Fields:    Translation:HumansCells
    22. Zhao R, Geng Q, Chang L, Wei P, Luo Y, Shi X, Asiri AM, Lu S, Wang Z, Sun X. Cu3P nanoparticle-reduced graphene oxide hybrid: an efficient electrocatalyst to realize N2-to-NH3 conversion under ambient conditions. Chem Commun (Camb). 2020 Aug 13; 56(65):9328-9331. PMID: 32671370.
      Citations: 1     Fields:    
    23. Jiang X, Lv X, Chang L, Yan Y, Ji H, Sun H, Guo F, Rodgers MA, Yin P, Wang L. Molecular characterization of hepatitis C virus for subtype determination and resistance-associated substitutions detection among Chinese voluntary blood donors. Antiviral Res. 2020 09; 181:104871. PMID: 32717286.
      Citations: 1     Fields:    Translation:HumansCells
    24. Fan M, Wang J, Wang S, Li T, Pan H, Liu H, Xu H, Zhernakova DV, O'Brien SJ, Feng Z, Chang L, Dai E, Lu J, Xi H, Yu Y, Zhang J, Wang B, Zeng Z. New Gene Variants Associated with the Risk of Chronic HBV Infection. Virol Sin. 2020 Aug; 35(4):378-387. PMID: 32297155.
      Citations: 1     Fields:    Translation:HumansCells
    25. Xie H, Wang H, Geng Q, Xing Z, Wang W, Chen J, Ji L, Chang L, Wang Z, Mao J. Oxygen Vacancies of Cr-Doped CeO2 Nanorods That Efficiently Enhance the Performance of Electrocatalytic N2 Fixation to NH3 under Ambient Conditions. Inorg Chem. 2019 May 06; 58(9):5423-5427. PMID: 31007026.
      Citations: 3     Fields:    
    26. Gao C, Fan YL, Zhao F, Ren QC, Wu X, Chang L, Gao F. Quinolone derivatives and their activities against methicillin-resistant Staphylococcus aureus (MRSA). Eur J Med Chem. 2018 Sep 05; 157:1081-1095. PMID: 30179746.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    27. Jia HM, Jia HJ, Cai QL, Wang Y, Zhao HB, Yang WF, Wang GY, Li YH, Zhan DL, Shen YT, Niu QF, Chang L, Qiu J, Zhao L, Xie HB, Fu WY, Jin J, Li XW, Jiao Y, Zhou CC, Tu T, Chai CY, Gao JL, Fan LJ, van de Weg E, Wang JY, Gao ZS. The red bayberry genome and genetic basis of sex determination. Plant Biotechnol J. 2019 02; 17(2):397-409. PMID: 29992702.
      Citations: 37     Fields:    Translation:Animals
    28. Chang L, Baseggio O, Sementa L, Cheng D, Fronzoni G, Toffoli D, Apr? E, Stener M, Fortunelli A. Individual Component Map of Rotatory Strength and Rotatory Strength Density Plots As Analysis Tools of Circular Dichroism Spectra of Complex Systems. J Chem Theory Comput. 2018 Jul 10; 14(7):3703-3714. PMID: 29897750.
      Citations: 3     Fields:    
    29. He W, Han X, An M, Hai Y, Chang L, Liu C, Wang L, Shang H. Near Full-Length Genome Sequence of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/CRF07_BC) Detected Among Blood Donors in North China. AIDS Res Hum Retroviruses. 2017 12; 33(12):1265-1269. PMID: 28712312.
      Citations:    Fields:    Translation:HumansCells
    30. Youn UJ, Sripisut T, Miklossy G, Turkson J, Laphookhieo S, Chang LC. Bioactive polyprenylated benzophenone derivatives from the fruits extracts of Garcinia xanthochymus. Bioorg Med Chem Lett. 2017 08 15; 27(16):3760-3765. PMID: 28729053.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    31. Zhang S, Xu Z, Gao C, Ren QC, Chang L, Lv ZS, Feng LS. Triazole derivatives and their anti-tubercular activity. Eur J Med Chem. 2017 Sep 29; 138:501-513. PMID: 28692915.
      Citations: 63     Fields:    Translation:HumansCells
    32. Youn UJ, Park EJ, Kondratyuk TP, Sripisut T, Laphookhieo S, Pezzuto JM, Chang LC. Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis. Fitoterapia. 2016 Oct; 114:92-97. PMID: 27575322.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    33. Youn UJ, Park EJ, Kondratyuk TP, Sang-Ngern M, Wall MM, Wei Y, Pezzuto JM, Chang LC. Anti-inflammatory and Quinone Reductase Inducing Compounds from Fermented Noni (Morinda citrifolia) Juice Exudates. J Nat Prod. 2016 06 24; 79(6):1508-13. PMID: 27196335.
      Citations: 9     Fields:    Translation:AnimalsCells
    34. Park EJ, Sang-Ngern M, Chang LC, Pezzuto JM. Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4?-hydroxywithanolide E isolated from Physalis peruviana. Mol Nutr Food Res. 2016 06; 60(6):1482-500. PMID: 27006100.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    35. Sang-Ngern M, Youn UJ, Park EJ, Kondratyuk TP, Simmons CJ, Wall MM, Ruf M, Lorch SE, Leong E, Pezzuto JM, Chang LC. Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity. Bioorg Med Chem Lett. 2016 Jun 15; 26(12):2755-2759. PMID: 27210437.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    36. Chang L, Wang G, Jia T, Zhang L, Li Y, Han Y, Zhang K, Lin G, Zhang R, Li J, Wang L. Armored long non-coding RNA MEG3 targeting EGFR based on recombinant MS2 bacteriophage virus-like particles against hepatocellular carcinoma. Oncotarget. 2016 Apr 26; 7(17):23988-4004. PMID: 26992211.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    37. Chang L, Liu XL, Di Fan D, Miao YQ, Zhang H, Ma HP, Liu QY, Ma P, Xue WM, Luo YE, Fan HM. The efficiency of magnetic hyperthermia and in vivo histocompatibility for human-like collagen protein-coated magnetic nanoparticles. Int J Nanomedicine. 2016; 11:1175-85. PMID: 27042065.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    38. Miklossy G, Youn UJ, Yue P, Zhang M, Chen CH, Hilliard TS, Paladino D, Li Y, Choi J, Sarkaria JN, Kawakami JK, Wongwiwatthananukit S, Chen Y, Sun D, Chang LC, Turkson J. Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin a-2 Expression, and Induce Antitumor Effects against Human Glioma. J Med Chem. 2015 Oct 08; 58(19):7734-48. PMID: 26331426.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    39. Youn UJ, Sripisut T, Park EJ, Kondratyuk TP, Fatima N, Simmons CJ, Wall MM, Sun D, Pezzuto JM, Chang LC. Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4719-4723. PMID: 26343828.
      Citations: 12     Fields:    Translation:AnimalsCells
    40. Huang Y, Wang C, Yao Y, Zuo X, Chen S, Xu C, Zhang H, Lu Q, Chang L, Wang F, Wang P, Zhang R, Hu Z, Song Q, Yang X, Li C, Li S, Zhao Y, Yang Q, Yin D, Wang X, Si W, Li X, Xiong X, Wang D, Huang Y, Luo C, Li J, Wang J, Chen J, Wang L, Wang L, Han M, Ye J, Chen F, Liu J, Liu Y, Wu G, Yang B, Cheng X, Liao Y, Wu Y, Ke T, Chen Q, Tu X, Elston R, Rao S, Yang Y, Xia Y, Wang QK. Molecular Basis of Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS Gene-Gene Interaction Involved in Atrial Fibrillation. PLoS Genet. 2015 Aug; 11(8):e1005393. PMID: 26267381.
      Citations: 34     Fields:    Translation:HumansCells
    41. Chung CG, James AW, Asatrian G, Chang L, Nguyen A, Le K, Bayani G, Lee R, Stoker D, Pang S, Zhang X, Ting K, P?ault B, Soo C. Human perivascular stem cell-based bone graft substitute induces rat spinal fusion. Stem Cells Transl Med. 2015 May; 4(5):538. PMID: 25926331.
      Citations: 12     Fields:    
    42. Saleem S, Jafri L, ul Haq I, Chang LC, Calderwood D, Green BD, Mirza B. Plants Fagonia cretica L. and Hedera nepalensis K. Koch contain natural compounds with potent dipeptidyl peptidase-4 (DPP-4) inhibitory activity. J Ethnopharmacol. 2014 Oct 28; 156:26-32. PMID: 25169215.
      Citations: 23     Fields:    Translation:Animals
    43. Chung CG, James AW, Asatrian G, Chang L, Nguyen A, Le K, Bayani G, Lee R, Stoker D, Zhang X, Ting K, P?ault B, Soo C. Human perivascular stem cell-based bone graft substitute induces rat spinal fusion. Stem Cells Transl Med. 2014 Oct; 3(10):1231-41. PMID: 25154782.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    44. Yong Y, Pan L, Ren Y, Fatima N, Ahmed S, Chang LC, Zhang X, Kinghorn AD, Swanson SM, Carcache de Blanco EJ. Assay development for the discovery of semaphorin 3B inducing agents from natural product sources. Fitoterapia. 2014 Oct; 98:184-91. PMID: 25016954.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    45. Chang L, Podoll JD, Wang W, Walls S, O'Rourke CP, Wang X. Structure-activity relationship studies of the tricyclic indoline resistance-modifying agent. J Med Chem. 2014 May 08; 57(9):3803-17. PMID: 24694192.
      Citations: 7     Fields:    Translation:HumansCells
    46. Chai X, Youn UJ, Sun D, Dai J, Williams P, Kondratyuk TP, Borris RP, Davies J, Villanueva IG, Pezzuto JM, Chang LC. Herbicidin congeners, undecose nucleosides from an organic extract of Streptomyces sp. L-9-10. J Nat Prod. 2014 Feb 28; 77(2):227-33. PMID: 24533857.
      Citations: 5     Fields:    Translation:HumansCells
    47. Youn UJ, Miklossy G, Chai X, Wongwiwatthananukit S, Toyama O, Songsak T, Turkson J, Chang LC. Bioactive sesquiterpene lactones and other compounds isolated from Vernonia cinerea. Fitoterapia. 2014 Mar; 93:194-200. PMID: 24370662.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    48. Xiong X, Xu C, Zhang Y, Li X, Wang B, Wang F, Yang Q, Wang D, Wang X, Li S, Chen S, Zhao Y, Yin D, Huang Y, Zhu X, Wang L, Wang L, Chang L, Xu C, Li H, Ke T, Ren X, Wu Y, Zhang R, Wu T, Xia Y, Yang Y, Ma X, Tu X, Wang QK. BRG1 variant rs1122608 on chromosome 19p13.2 confers protection against stroke and regulates expression of pre-mRNA-splicing factor SFRS3. Hum Genet. 2014 May; 133(5):499-508. PMID: 24190014.
      Citations: 21     Fields:    Translation:HumansCells
    49. Li X, Huang Y, Yin D, Wang D, Xu C, Wang F, Yang Q, Wang X, Li S, Chen S, Xiong X, Huang Y, Zhao Y, Wang L, Zhu X, Su Z, Zhou B, Zhang Y, Wang L, Chang L, Xu C, Li H, Ke T, Ren X, Cheng X, Yang Y, Liao Y, Tu X, Wang QK. Meta-analysis identifies robust association between SNP rs17465637 in MIA3 on chromosome 1q41 and coronary artery disease. Atherosclerosis. 2013 Nov; 231(1):136-40. PMID: 24125424.
      Citations: 17     Fields:    Translation:Humans
    50. Sun Z, Wang HQ, Liu ZH, Chang L, Chen YF, Zhang YZ, Zhang WL, Gao Y, Wan ZY, Che L, Liu X, Samartzis D, Luo ZJ. Down-regulated CK8 expression in human intervertebral disc degeneration. Int J Med Sci. 2013; 10(8):948-56. PMID: 23801880.
      Citations: 20     Fields:    Translation:HumansCells
    51. Youn UJ, Chai X, Park EJ, Kondratyuk TP, Simmons CJ, Borris RP, Mirza B, Pezzuto JM, Chang LC. Biologically active withanolides from Withania coagulans. J Nat Prod. 2013 Jan 25; 76(1):22-8. PMID: 23316950.
      Citations: 12     Fields:    Translation:AnimalsCells
    52. Youn UJ, Park EJ, Kondratyuk TP, Simmons CJ, Borris RP, Tanamatayarat P, Wongwiwatthananukit S, Toyama O, Songsak T, Pezzuto JM, Chang LC. Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea. Bioorg Med Chem Lett. 2012 Sep 01; 22(17):5559-62. PMID: 22850207.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    53. Park EJ, Cheenpracha S, Chang LC, Pezzuto JM. Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by epimuqubilin A via IKK/I?B/NF-?B pathways in lipopolysaccharide-stimulated RAW 264.7 cells. Phytochem Lett. 2011 Dec 01; 4(4):426-431. PMID: 22180763.
      Citations:    
    54. Park EJ, Cheenpracha S, Chang LC, Kondratyuk TP, Pezzuto JM. Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2'-O-acetyl-a-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera. Nutr Cancer. 2011; 63(6):971-82. PMID: 21774591.
      Citations: 29     Fields:    Translation:AnimalsCells
    55. Cheenpracha S, Park EJ, Yoshida WY, Barit C, Wall M, Pezzuto JM, Chang LC. Potential anti-inflammatory phenolic glycosides from the medicinal plant Moringa oleifera fruits. Bioorg Med Chem. 2010 Sep 01; 18(17):6598-602. PMID: 20685125.
      Citations: 53     Fields:    Translation:Animals
    56. Cheenpracha S, Park EJ, Rostama B, Pezzuto JM, Chang LC. Inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells by the norsesterterpene peroxide, epimuqubilin A. Mar Drugs. 2010 Mar 01; 8(3):429-37. PMID: 20411107.
      Citations: 19     Fields:    Translation:AnimalsCells
    57. Barker LP, Lien BA, Brun OS, Schaak DD, McDonough KA, Chang LC. A Mycobacterium marinum zone of inhibition assay as a method for screening potential antimycobacterial compounds from marine extracts. Planta Med. 2007 Jun; 73(6):559-63. PMID: 17534789.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    58. Kinghorn AD, Su BN, Jang DS, Chang LC, Lee D, Gu JQ, Carcache-Blanco EJ, Pawlus AD, Lee SK, Park EJ, Cuendet M, Gills JJ, Bhat K, Park HS, Mata-Greenwood E, Song LL, Jang M, Pezzuto JM. Natural inhibitors of carcinogenesis. Planta Med. 2004 Aug; 70(8):691-705. PMID: 15326546.
      Citations: 35     Fields:    Translation:HumansAnimals
    59. Su BN, Chang LC, Park EJ, Cuendet M, Santarsiero BD, Mesecar AD, Mehta RG, Fong HH, Pezzuto JM, Kinghorn AD. Bioactive constituents of the seeds of Brucea javanica. Planta Med. 2002 Aug; 68(8):730-3. PMID: 12221597.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    60. Chang LC, Song LL, Park EJ, Luyengi L, Lee KJ, Farnsworth NR, Pezzuto JM, Kinghorn AD. Bioactive constituents of Thuja occidentalis. J Nat Prod. 2000 Sep; 63(9):1235-8. PMID: 11000026.
      Citations: 15     Fields:    Translation:AnimalsCells
    61. Chang LC, Gerh?user C, Song L, Farnsworth NR, Pezzuto JM, Kinghorn AD. Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase II enzyme, quinone reductase. J Nat Prod. 1997 Sep; 60(9):869-73. PMID: 9322358.
      Citations: 10     Fields:    Translation:AnimalsCells
    Chang's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (326)
    Explore
    _
    Co-Authors (1)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

    For technical support please contact support