Tumor Necrosis Factor-alpha

"Tumor Necrosis Factor-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

Descriptor ID	D014409
MeSH Number(s)	D12.644.276.374.500.800 D12.644.276.374.750.626 D12.776.124.900 D12.776.395.930 D12.776.467.374.500.800 D12.776.467.374.750.626 D23.529.374.500.800 D23.529.374.750.626
Concept/Terms	Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha Tumor Necrosis Factor alpha Cachectin Cachectin-Tumor Necrosis Factor Cachectin Tumor Necrosis Factor Tumor Necrosis Factor Ligand Superfamily Member 2 Tumor Necrosis Factor TNF Superfamily, Member 2 TNFalpha TNF-alpha

Below are MeSH descriptors whose meaning is more general than "Tumor Necrosis Factor-alpha".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Monokines [D12.644.276.374.500]
Tumor Necrosis Factor-alpha [D12.644.276.374.500.800]
Tumor Necrosis Factors [D12.644.276.374.750]
Tumor Necrosis Factor-alpha [D12.644.276.374.750.626]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Tumor Necrosis Factor-alpha [D12.776.124.900]
Glycoproteins [D12.776.395]
Tumor Necrosis Factor-alpha [D12.776.395.930]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Monokines [D12.776.467.374.500]
Tumor Necrosis Factor-alpha [D12.776.467.374.500.800]
Tumor Necrosis Factors [D12.776.467.374.750]
Tumor Necrosis Factor-alpha [D12.776.467.374.750.626]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Monokines [D23.529.374.500]
Tumor Necrosis Factor-alpha [D23.529.374.500.800]
Tumor Necrosis Factors [D23.529.374.750]
Tumor Necrosis Factor-alpha [D23.529.374.750.626]

Below are MeSH descriptors whose meaning is related to "Tumor Necrosis Factor-alpha".

Below are MeSH descriptors whose meaning is more specific than "Tumor Necrosis Factor-alpha".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tumor Necrosis Factor-alpha" by people in this website by year, and whether "Tumor Necrosis Factor-alpha" was a major or minor topic of these publications.

Bar chart showing 254 publications over 30 distinct years, with a maximum of 20 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	3	0	3
1995	1	0	1
1996	2	1	3
1997	2	3	5
1998	1	2	3
1999	0	3	3
2001	2	2	4
2002	9	11	20
2003	6	9	15
2004	4	3	7
2005	7	10	17
2006	4	6	10
2007	3	13	16
2008	2	6	8
2009	3	9	12
2010	4	11	15
2011	1	6	7
2012	0	11	11
2013	7	10	17
2014	4	6	10
2015	2	5	7
2016	3	7	10
2017	3	5	8
2018	1	5	6
2019	3	6	9
2020	0	3	3
2021	4	4	8
2022	0	5	5
2023	1	9	10
2024	0	1	1

Below are the most recent publications written about "Tumor Necrosis Factor-alpha" by people in Profiles.

Nyarko-Danquah I, Pajarillo E, Kim S, Digman A, Multani HK, Ajayi I, Son DS, Aschner M, Lee E. Microglial Sp1 induced LRRK2 upregulation in response to manganese exposure, and 17?-estradiol afforded protection against this manganese toxicity. Neurotoxicology. 2024 Jul; 103:105-114.

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Khan M, Hearn K, Parry C, Rashid M, Brim H, Ashktorab H, Kwabi-Addo B. Mechanism of Antitumor Effects of Saffron in Human Prostate Cancer Cells. Nutrients. 2023 12 28; 16(1).

View in: PubMed
Ahmed SA, Mendonca P, Messeha SS, Oriaku ET, Soliman KFA. The Anticancer Effects of Marine Carotenoid Fucoxanthin through Phosphatidylinositol 3-Kinase (PI3K)-AKT Signaling on Triple-Negative Breast Cancer Cells. Molecules. 2023 Dec 21; 29(1).

View in: PubMed
Sun C, Rahman MSU, Enkhjargal B, Peng J, Zhou K, Xie Z, Wu L, Zhang T, Zhu Q, Tang J, Zeng Y, Zhang JH, Xu S. Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats. Exp Neurol. 2024 01; 371:114585.

View in: PubMed
Suarez JS, Novelli F, Goto K, Ehara M, Steele M, Kim JH, Zolondick AA, Xue J, Xu R, Saito M, Pastorino S, Minaai M, Takanishi Y, Emi M, Pagano I, Wakeham A, Berger T, Pass HI, Gaudino G, Mak TW, Carbone M, Yang H. HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma. Proc Natl Acad Sci U S A. 2023 09 26; 120(39):e2307999120.

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Simino LAP, Baqueiro MN, Panzarin C, Lopes PKF, G?is MM, Simabuco FM, Ign?cio-Souza LM, Milanski M, Ross MG, Desai M, Torsoni AS, Torsoni MA. Hypothalamic a7 nicotinic acetylcholine receptor (a7nAChR) is downregulated by TNFa-induced Let-7 overexpression driven by fatty acids. FASEB J. 2023 09; 37(9):e23120.

View in: PubMed
Banerjee S, Xu W, Doctor A, Driss A, Nezhat C, Sidell N, Taylor RN, Thompson WE, Chowdhury I. TNFa-Induced Altered miRNA Expression Links to NF-?B Signaling Pathway in Endometriosis. Inflammation. 2023 Dec; 46(6):2055-2070.

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Adinew GM, Messeha S, Taka E, Mochona B, Redda KK, Soliman KFA. Thymoquinone Inhibition of Chemokines in TNF-a-Induced Inflammatory and Metastatic Effects in Triple-Negative Breast Cancer Cells. Int J Mol Sci. 2023 Jun 08; 24(12).

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Kanga KJW, Kanga LHB, Mendonca P, Soliman KFA, Ferguson DT, Reed SL, Darling-Reed S. Attenuative Effect of Diallyl Trisulfide on Caspase Activity in TNF-a-induced Triple Negative Breast Cancer Cells. Anticancer Res. 2023 Jun; 43(6):2393-2405.

View in: PubMed
Pajarillo E, Kim S, Digman A, Dutton M, Son DS, Aschner M, Lee E. The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. J Biol Chem. 2023 07; 299(7):104879.

View in: PubMed

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