Lactoferrin

"Lactoferrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion.

Descriptor ID	D007781
MeSH Number(s)	D08.811.277.656.300.760.471 D08.811.277.656.959.350.471 D12.776.157.427.750.249 D12.776.256.626.816.500.507 D12.776.377.457.507 D12.776.395.507 D12.776.556.579.750.249
Concept/Terms	Lactoferrin Lactoferrin Lactotransferrin

Below are MeSH descriptors whose meaning is more general than "Lactoferrin".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Serine Endopeptidases [D08.811.277.656.300.760]
Lactoferrin [D08.811.277.656.300.760.471]
Serine Proteases [D08.811.277.656.959]
Serine Endopeptidases [D08.811.277.656.959.350]
Lactoferrin [D08.811.277.656.959.350.471]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Iron-Binding Proteins [D12.776.157.427]
Transferrins [D12.776.157.427.750]
Lactoferrin [D12.776.157.427.750.249]
Dietary Proteins [D12.776.256]
Milk Proteins [D12.776.256.626]
Whey Proteins [D12.776.256.626.816]
Lactoglobulins [D12.776.256.626.816.500]
Lactoferrin [D12.776.256.626.816.500.507]
Globulins [D12.776.377]
Lactoglobulins [D12.776.377.457]
Lactoferrin [D12.776.377.457.507]
Glycoproteins [D12.776.395]
Lactoferrin [D12.776.395.507]
Metalloproteins [D12.776.556]
Iron-Binding Proteins [D12.776.556.579]
Transferrins [D12.776.556.579.750]
Lactoferrin [D12.776.556.579.750.249]

Below are MeSH descriptors whose meaning is related to "Lactoferrin".

Below are MeSH descriptors whose meaning is more specific than "Lactoferrin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Lactoferrin" by people in this website by year, and whether "Lactoferrin" was a major or minor topic of these publications.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	0	1	1
2013	1	0	1
2019	1	0	1
2020	2	0	2
2025	1	0	1

Below are the most recent publications written about "Lactoferrin" by people in Profiles.

Pires MC, Jungbauer A, Lau D, Young C, Hoffmann P, de P?dua TF, Gerstweiler L. Column ageing of agarose-based chromatography in industrial lactoferrin purification. J Chromatogr A. 2025 Oct 11; 1760:466274.

View in: PubMed
Nakamura-Bencomo S, Gutierrez DA, Robles-Escajeda E, Iglesias-Figueroa B, Siqueiros-Cend?n TS, Espinoza-S?nchez EA, Ar?valo-Gallegos S, Aguilera RJ, Rasc?n-Cruz Q, Varela-Ramirez A. Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities. Invest New Drugs. 2021 04; 39(2):400-415.

View in: PubMed
Gonz?lez-S?nchez M, Bartolome F, Antequera D, Puertas-Mart?n V, Gonz?lez P, G?mez-Grande A, Llamas-Velasco S, Herrero-San Mart?n A, P?rez-Mart?nez D, Villarejo-Galende A, Atienza M, Palomar-Bonet M, Cantero JL, Perry G, Orive G, Iba?ez B, Bueno H, Fuster V, Carro E. Decreased salivary lactoferrin levels are specific to Alzheimer's disease. EBioMedicine. 2020 Jul; 57:102834.

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Iglesias-Figueroa BF, Siqueiros-Cend?n TS, Gutierrez DA, Aguilera RJ, Espinoza-S?nchez EA, Ar?valo-Gallegos S, Varela-Ramirez A, Rasc?n-Cruz Q. Recombinant human lactoferrin induces apoptosis, disruption of F-actin structure and cell cycle arrest with selective cytotoxicity on human triple negative breast cancer cells. Apoptosis. 2019 08; 24(7-8):562-577.

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Ouhara K, Savitri IJ, Fujita T, Kittaka M, Kajiya M, Iwata T, Miyagawa T, Yamakawa M, Shiba H, Kurihara H. miR-584 expressed in human gingival epithelial cells is induced by Porphyromonas gingivalis stimulation and regulates interleukin-8 production via lactoferrin receptor. J Periodontol. 2014 Jun; 85(6):e198-204.

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Leid JG, Kerr M, Selgado C, Johnson C, Moreno G, Smith A, Shirtliff ME, O'Toole GA, Cope EK. Flagellum-mediated biofilm defense mechanisms of Pseudomonas aeruginosa against host-derived lactoferrin. Infect Immun. 2009 Oct; 77(10):4559-66.

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Turchany JM, McCaffery JM, Aley SB, Gillin FD. Ultrastructural effects of lactoferrin binding on Giardia lamblia trophozoites. J Eukaryot Microbiol. 1997 Jan-Feb; 44(1):68-72.

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Turchany JM, Aley SB, Gillin FD. Giardicidal activity of lactoferrin and N-terminal peptides. Infect Immun. 1995 Nov; 63(11):4550-2.

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Lima MF, Beltz LA, Kierszenbaum F. Trypanosoma cruzi: a specific surface marker for the amastigote form. J Protozool. 1988 Feb; 35(1):108-10.

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Lima MF, Kierszenbaum F. Lactoferrin effects of phagocytic cell function. II. The presence of iron is required for the lactoferrin molecule to stimulate intracellular killing by macrophages but not to enhance the uptake of particles and microorganisms. J Immunol. 1987 Sep 01; 139(5):1647-51.

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