"Furin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.
| Descriptor ID |
D045683
|
| MeSH Number(s) |
D08.811.277.656.300.760.353 D08.811.277.656.837.249 D08.811.277.656.959.350.353
|
| Concept/Terms |
Furin- Furin
- Dibasic Processing Enzyme
- Processing Enzyme, Dibasic
- Furin Protein
- SPC1 Proteinase
- Paired Basic Amino Acid Cleaving Enzyme
|
Below are MeSH descriptors whose meaning is more general than "Furin".
Below are MeSH descriptors whose meaning is more specific than "Furin".
This graph shows the total number of publications written about "Furin" by people in this website by year, and whether "Furin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Furin" by people in Profiles.
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Mondal T, Shivange G, Habieb A, Tushir-Singh J. A Feasible Alternative Strategy Targeting Furin Disrupts SARS-CoV-2 Infection Cycle. Microbiol Spectr. 2022 02 23; 10(1):e0236421.
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Tarek M, Abdelzaher H, Kobeissy F, El-Fawal HAN, Salama MM, Abdelnaser A. Bioinformatics Analysis of Allele Frequencies and Expression Patterns of ACE2, TMPRSS2 and FURIN in Different Populations and Susceptibility to SARS-CoV-2. Genes (Basel). 2021 Jul 05; 12(7).
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Wan S, Cao S, Wang X, Zhou Y, Yan W, Gu X, Wu TC, Pang X. Generation and preliminary characterization of vertebrate-specific replication-defective Zika virus. Virology. 2021 01 02; 552:73-82.
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Cano-Monreal GL, Williams JC, Heidner HW. An arthropod enzyme, Dfurin1, and a vertebrate furin homolog display distinct cleavage site sequence preferences for a shared viral proprotein substrate. J Insect Sci. 2010; 10:29.
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Jin HJ, Dunn MA, Borthakur D, Kim YS. Refolding and purification of unprocessed porcine myostatin expressed in Escherichia coli. Protein Expr Purif. 2004 May; 35(1):1-10.
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Klimstra WB, Heidner HW, Johnston RE. The furin protease cleavage recognition sequence of Sindbis virus PE2 can mediate virion attachment to cell surface heparan sulfate. J Virol. 1999 Aug; 73(8):6299-306.