Granzymes

"Granzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.

Descriptor ID	D053804
MeSH Number(s)	D08.811.277.656.300.760.397 D08.811.277.656.959.350.397
Concept/Terms	Granzymes Granzymes Granzyme Granzyme M Granzyme M Granzyme C Granzyme C Granzyme K Granzyme K Natural Killer Cell Granule Tryptase-2 Natural Killer Cell Granule Tryptase 2 NK-Tryptase-2 NK Tryptase 2 Granzyme-3 Granzyme 3 Granzyme A Granzyme A Cytotoxic T-Lymphocyte Proteinase 1 Cytotoxic T Lymphocyte Proteinase 1 Hanukah Factor Granzyme B Granzyme B Fragmentin 2 Cytotoxic T-Lymphocyte Associated 1 Protein Cytotoxic T Lymphocyte Associated 1 Protein Granzyme-Like Protein III Granzyme Like Protein III Cytotoxic Serine Protease B

Below are MeSH descriptors whose meaning is more general than "Granzymes".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Serine Endopeptidases [D08.811.277.656.300.760]
Granzymes [D08.811.277.656.300.760.397]
Serine Proteases [D08.811.277.656.959]
Serine Endopeptidases [D08.811.277.656.959.350]
Granzymes [D08.811.277.656.959.350.397]

Below are MeSH descriptors whose meaning is more specific than "Granzymes".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Granzymes" by people in this website by year, and whether "Granzymes" was a major or minor topic of these publications.

Bar chart showing 8 publications over 6 distinct years, with a maximum of 2 publications in 2013 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2012	1	0	1
2013	1	1	2
2015	0	2	2
2020	0	1	1
2022	0	1	1
2023	0	1	1

Below are the most recent publications written about "Granzymes" by people in Profiles.

Ii T, Chambers JK, Nakashima K, Goto-Koshino Y, Uchida K. Intraepithelial lymphocytes are associated with epithelial injury in feline intestinal T-cell lymphoma. J Vet Med Sci. 2024 Jan 26; 86(1):101-110.

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Ii T, Chambers JK, Nakashima K, Goto-Koshino Y, Mizuno T, Uchida K. Intraepithelial cytotoxic lymphocytes are associated with a poor prognosis in feline intestinal T-cell lymphoma. Vet Pathol. 2022 11; 59(6):931-939.

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Principe N, Kidman J, Goh S, Tilsed CM, Fisher SA, Fear VS, Forbes CA, Zemek RM, Chopra A, Watson M, Dick IM, Boon L, Holt RA, Lake RA, Nowak AK, Lesterhuis WJ, McDonnell AM, Chee J. Tumor Infiltrating Effector Memory Antigen-Specific CD8+ T Cells Predict Response to Immune Checkpoint Therapy. Front Immunol. 2020; 11:584423.

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Thounaojam MC, Dudimah DF, Pellom ST, Uzhachenko RV, Carbone DP, Dikov MM, Shanker A. Bortezomib enhances expression of effector molecules in anti-tumor CD8+ T lymphocytes by promoting Notch-nuclear factor-?B crosstalk. Oncotarget. 2015 Oct 20; 6(32):32439-55.

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Hoffmann PR, Panigada M, Soprana E, Terry F, Bandar IS, Napolitano A, Rose AH, Hoffmann FW, Ndhlovu LC, Belcaid M, Moise L, De Groot AS, Carbone M, Gaudino G, Matsui T, Siccardi A, Bertino P. Preclinical development of HIvax: Human survivin highly immunogenic vaccines. Hum Vaccin Immunother. 2015; 11(7):1585-95.

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Kamalakaran S, Chaganty BK, Gupta R, Guentzel MN, Chambers JP, Murthy AK, Arulanandam BP. Vaginal chlamydial clearance following primary or secondary infection in mice occurs independently of TNF-a. Front Cell Infect Microbiol. 2013; 3:11.

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Spencer CT, Abate G, Sakala IG, Xia M, Truscott SM, Eickhoff CS, Linn R, Blazevic A, Metkar SS, Peng G, Froelich CJ, Hoft DF. Granzyme A produced by ?(9)d(2) T cells induces human macrophages to inhibit growth of an intracellular pathogen. PLoS Pathog. 2013 Jan; 9(1):e1003119.

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Sanapala S, Yu JJ, Murthy AK, Li W, Guentzel MN, Chambers JP, Klose KE, Arulanandam BP. Perforin- and granzyme-mediated cytotoxic effector functions are essential for protection against Francisella tularensis following vaccination by the defined F. tularensis subsp. novicida ?fopC vaccine strain. Infect Immun. 2012 Jun; 80(6):2177-85.

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Calarota SA, Otero M, Robinson TM, Dai A, Lewis MG, Boyer JD, Weiner DB. Independence of granzyme B secretion and interferon- gamma production during acute simian immunodeficiency virus infection. J Infect Dis. 2006 May 15; 193(10):1441-50.

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