Tissue Plasminogen Activator

"Tissue Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.

Descriptor ID	D010959
MeSH Number(s)	D08.811.277.656.300.760.875 D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970
Concept/Terms	Tissue Plasminogen Activator Tissue Plasminogen Activator Plasminogen Activator, Tissue Tissue Activator D-44 Tissue Activator D 44 Tisokinase Tissue-Type Plasminogen Activator Tissue Type Plasminogen Activator TTPA T-Plasminogen Activator T Plasminogen Activator Alteplase Plasminogen Activator, Tissue-Type Plasminogen Activator, Tissue Type Activase Activase Actilyse Actilyse Lysatec rt-PA Lysatec rt PA Lysatec rtPA

Below are MeSH descriptors whose meaning is more general than "Tissue Plasminogen Activator".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Serine Endopeptidases [D08.811.277.656.300.760]
Tissue Plasminogen Activator [D08.811.277.656.300.760.875]
Serine Proteases [D08.811.277.656.959]
Serine Endopeptidases [D08.811.277.656.959.350]
Tissue Plasminogen Activator [D08.811.277.656.959.350.875]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Blood Coagulation Factors [D12.776.124.125]
Plasminogen Activators [D12.776.124.125.662]
Tissue Plasminogen Activator [D12.776.124.125.662.768]
Biological Factors [D23]
Blood Coagulation Factors [D23.119]
Tissue Plasminogen Activator [D23.119.970]

Below are MeSH descriptors whose meaning is related to "Tissue Plasminogen Activator".

Below are MeSH descriptors whose meaning is more specific than "Tissue Plasminogen Activator".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tissue Plasminogen Activator" by people in this website by year, and whether "Tissue Plasminogen Activator" was a major or minor topic of these publications.

Bar chart showing 16 publications over 14 distinct years, with a maximum of 2 publications in 2004 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	0	1
1997	1	0	1
2004	0	2	2
2010	1	0	1
2012	0	1	1
2013	1	0	1
2015	0	1	1
2016	1	0	1
2018	1	0	1
2019	0	1	1
2020	0	1	1
2021	0	1	1
2022	0	2	2
2023	0	1	1

Below are the most recent publications written about "Tissue Plasminogen Activator" by people in Profiles.

Desai R, Mondal A, Prasad A, Vyas A, Jain A, Rupareliya C, Shah M, Paul T, Kumar G, Sachdeva R. Concurrent Cardio-Cerebral Infarctions in COVID-19: A Systematic Review of Published Case Reports/Series. Curr Probl Cardiol. 2023 Oct; 48(10):101814.

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Furuya H, Sasaki Y, Chen R, Peres R, Hokutan K, Murakami K, Kim N, Chan OTM, Pagano I, Dyrskj?t L, Jensen JB, Malmstrom PU, Segersten U, Sun Y, Arab A, Goodarzi H, Goodison S, Rosser CJ. PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity. Sci Rep. 2022 07 16; 12(1):12186.

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Akulian J, Bedawi EO, Abbas H, Argento C, Arnold DT, Balwan A, Batra H, Uribe Becerra JP, Belanger A, Berger K, Burks AC, Chang J, Chrissian AA, DiBardino DM, Fuentes XF, Gesthalter YB, Gilbert CR, Glisinski K, Godfrey M, Gorden JA, Grosu H, Gupta M, Kheir F, Ma KC, Majid A, Maldonado F, Maskell NA, Mehta H, Mercer J, Mullon J, Nelson D, Nguyen E, Pickering EM, Puchalski J, Reddy C, Revelo AE, Roller L, Sachdeva A, Sanchez T, Sathyanarayan P, Semaan R, Senitko M, Shojaee S, Story R, Thiboutot J, Wahidi M, Wilshire CL, Yu D, Zouk A, Rahman NM, Yarmus L. Bleeding Risk With Combination Intrapleural Fibrinolytic and Enzyme Therapy in Pleural Infection: An International, Multicenter, Retrospective Cohort Study. Chest. 2022 Dec; 162(6):1384-1392.

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Jimenez A, Ravinutala A, Eskenazi J, Xu P, Liu A. Consideration Needed for early Anticoagulation Following Intravenous tPA in Patients with COVID-19. J Stroke Cerebrovasc Dis. 2021 07; 30(7):105769.

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Camara R, Matei N, Zhang JH. Evolution of the stroke paradigm: A review of delayed recanalization. J Cereb Blood Flow Metab. 2021 05; 41(5):945-957.

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Shpak M, Korwek K, Nadasdy Z, Ramakrishnan A, Cowperthwaite M, Ankrom K, Jennings J, Moody A, Orndorff K, Fanale C. Driving stroke quality improvement at scale in EDs across a nationwide network of hospitals: strategies and interventions. Emerg Med J. 2019 Jul; 36(7):423-430.

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Kumar A, Adhikari D, Karmarkar A, Freburger J, Gozalo P, Mor V, Resnik L. Variation in Hospital-Based Rehabilitation Services Among Patients With Ischemic Stroke in the United States. Phys Ther. 2019 05 01; 99(5):494-506.

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Simon R, Meller R, Yang T, Pearson A, Wilson G. Enhancing Base Excision Repair of Mitochondrial DNA to Reduce Ischemic Injury Following Reperfusion. Transl Stroke Res. 2019 12; 10(6):664-671.

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Augello CJ, Noll JM, Distel TJ, Wainright JD, Stout CE, Ford BD. Identification of novel blood biomarker panels to detect ischemic stroke in patients and their responsiveness to therapeutic intervention. Brain Res. 2018 11 01; 1698:161-169.

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Moran JL, Nakagawa K, Asai SM, Koenig MA. 24/7 Neurocritical Care Nurse Practitioner Coverage Reduced Door-to-Needle Time in Stroke Patients Treated with Tissue Plasminogen Activator. J Stroke Cerebrovasc Dis. 2016 May; 25(5):1148-1152.

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