"Kininogens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.
| Descriptor ID |
D007704
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| MeSH Number(s) |
D12.644.276.812.654 D12.776.124.125.635 D12.776.467.812.654 D12.776.811.420 D23.119.630 D23.469.050.375.425 D23.529.812.654
|
| Concept/Terms |
Kininogens- Kininogens
- Prokinins
- Prekinins
- Cystatins, Kininogen
- Kininogen Cystatins
|
Below are MeSH descriptors whose meaning is more general than "Kininogens".
Below are MeSH descriptors whose meaning is more specific than "Kininogens".
This graph shows the total number of publications written about "Kininogens" by people in this website by year, and whether "Kininogens" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Kininogens" by people in Profiles.
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Alves JM, Martins AH, Lameu C, Glaser T, Boukli NM, Bassaneze V, Dariolli R, Nascimento IC, Martins PCM, de Souza HDN, Krieger JE, Casarini DE, Sales VM, Pesquero JB, Ulrich H. Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation. Stem Cell Rev Rep. 2019 02; 15(1):48-58.
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Monteiro AC, Schmitz V, Svensjo E, Gazzinelli RT, Almeida IC, Todorov A, de Arruda LB, Torrecilhas AC, Pesquero JB, Morrot A, Bouskela E, Bonomo A, Lima AP, M?ller-Esterl W, Scharfstein J. Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi. J Immunol. 2006 Nov 01; 177(9):6325-35.
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Martins AH, Resende RR, Majumder P, Faria M, Casarini DE, T?rnok A, Colli W, Pesquero JB, Ulrich H. Neuronal differentiation of P19 embryonal carcinoma cells modulates kinin B2 receptor gene expression and function. J Biol Chem. 2005 May 20; 280(20):19576-86.
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Ray S, Lukyanov P, Ochieng J. Members of the cystatin superfamily interact with MMP-9 and protect it from autolytic degradation without affecting its gelatinolytic activities. Biochim Biophys Acta. 2003 Dec 01; 1652(2):91-102.
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Song Q, Wang DZ, Harley RA, Chao L, Chao J. Cellular localization of low-molecular-weight kininogen and bradykinin B2 receptor mRNAs in human kidney. Am J Physiol. 1996 Jun; 270(6 Pt 2):F919-26.