"Pro-Opiomelanocortin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
| Descriptor ID |
D011333
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| MeSH Number(s) |
D06.472.699.327.935 D06.472.699.631.525.600 D12.644.400.400.935 D12.644.548.365.935 D12.644.548.691.525.690 D12.776.631.650.405.935 D12.776.811.800
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| Concept/Terms |
Pro-Opiomelanocortin- Pro-Opiomelanocortin
- Pro Opiomelanocortin
- ACTH-Endorphin Precursor
- ACTH Endorphin Precursor
- Endorphin-ACTH Precursor
- Endorphin ACTH Precursor
- Corticotropin-beta-Lipotropin Precursor
- Corticotropin beta Lipotropin Precursor
- POMC
- Proopiomelanocortin
- Pro-Opiocortin
- Pro Opiocortin
- Pro-Opio-Melanocortin
- Pro Opio Melanocortin
- Proopiocortin
- ACTH-beta-Lipotropin Precursor
- ACTH beta Lipotropin Precursor
- Pro-ACTH-Endorphin
- Pro ACTH Endorphin
|
Below are MeSH descriptors whose meaning is more general than "Pro-Opiomelanocortin".
Below are MeSH descriptors whose meaning is more specific than "Pro-Opiomelanocortin".
This graph shows the total number of publications written about "Pro-Opiomelanocortin" by people in this website by year, and whether "Pro-Opiomelanocortin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 2 | 2 |
| 2005 | 2 | 0 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Pro-Opiomelanocortin" by people in Profiles.
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Sun X, Fukami T, Li T, Desai M, Ross MG. Preferential development of neuropeptide Y/GABA circuit in hypothalamic arcuate nucleus in postnatal rats. Brain Res. 2016 Mar 15; 1635:27-40.
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Desai M, Li T, Han G, Ross MG. Programmed hyperphagia secondary to increased hypothalamic SIRT1. Brain Res. 2014 Nov 17; 1589:26-36.
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Nie Y, Ferrini MG, Liu Y, Anghel A, Paez Espinosa EV, Stuart RC, Lutfy K, Nillni EA, Friedman TC. Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2. Peptides. 2013 Sep; 47:99-109.
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Fukami T, Sun X, Li T, Desai M, Ross MG. Mechanism of programmed obesity in intrauterine fetal growth restricted offspring: paradoxically enhanced appetite stimulation in fed and fasting states. Reprod Sci. 2012 Apr; 19(4):423-30.
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Farhang B, Pietruszewski L, Lutfy K, Wagner EJ. The role of the NOP receptor in regulating food intake, meal pattern, and the excitability of proopiomelanocortin neurons. Neuropharmacology. 2010 Sep; 59(3):190-200.
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Keen-Rhinehart E, Desai M, Ross MG. Central insulin sensitivity in male and female juvenile rats. Horm Behav. 2009 Sep; 56(3):275-80.
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Marquez P, Baliram R, Dabaja I, Gajawada N, Lutfy K. The role of beta-endorphin in the acute motor stimulatory and rewarding actions of cocaine in mice. Psychopharmacology (Berl). 2008 Apr; 197(3):443-8.
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Das SK, Chatterjee D, Mukherjee S, Grimes A, Shen Y, Smith M, Ghosh S. Decrease in brain POMC mRNA expression and onset of obesity in guinea pigs exposed to 2-chloroethyl ethyl sulfide, a mustard analogue. Biochem Biophys Res Commun. 2006 Jan 06; 339(1):55-8.
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Koban M, Le WW, Hoffman GE. Changes in hypothalamic corticotropin-releasing hormone, neuropeptide Y, and proopiomelanocortin gene expression during chronic rapid eye movement sleep deprivation of rats. Endocrinology. 2006 Jan; 147(1):421-31.
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Wachira SJ, Hughes-Darden CA, Nicholas HB, Taylor CV, Robinson TJ. Neural melanocortin receptors are differentially expressed and regulated by stress in rat hypothalamic-pituitary-adrenal axis. Cell Mol Biol (Noisy-le-grand). 2004 Sep; 50(6):703-13.