Nicotine

"Nicotine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Descriptor ID	D009538
MeSH Number(s)	D03.132.760.570 D03.383.725.518
Concept/Terms	Nicotine Nicotine Nicotine Bitartrate Nicotine Bitartrate Bitartrate, Nicotine Nicotine Tartrate Tartrate, Nicotine

Below are MeSH descriptors whose meaning is more general than "Nicotine".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Alkaloids [D03.132]
Solanaceous Alkaloids [D03.132.760]
Nicotine [D03.132.760.570]
Heterocyclic Compounds, 1-Ring [D03.383]
Pyridines [D03.383.725]
Nicotine [D03.383.725.518]

Below are MeSH descriptors whose meaning is more specific than "Nicotine".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Nicotine" by people in this website by year, and whether "Nicotine" was a major or minor topic of these publications.

Bar chart showing 184 publications over 29 distinct years, with a maximum of 16 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1997	0	1	1
1999	1	0	1
2000	0	1	1
2001	2	1	3
2002	2	1	3
2003	2	2	4
2004	4	1	5
2005	4	2	6
2006	2	4	6
2007	4	1	5
2008	7	2	9
2009	4	4	8
2010	3	2	5
2011	2	2	4
2012	8	0	8
2013	7	2	9
2014	3	2	5
2015	5	1	6
2016	4	4	8
2017	8	4	12
2018	3	5	8
2019	6	4	10
2020	13	3	16
2021	4	2	6
2022	3	8	11
2023	4	9	13
2024	4	3	7
2025	2	1	3

Below are the most recent publications written about "Nicotine" by people in Profiles.

Wang J, Xu B, Wang Y, Liu J, Wang P, Porche R, Kim S, Yang R, Shao XM, Lutfy K, Liu L, Friedman TC, Jiang M, Liu Y. E-Cigarette Smoke Exposure Elevates Renal MR Expression and Induces BP Elevation. Hypertension. 2025 Sep; 82(9):1492-1504.

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Bakhshaie J, LaRowe LR, Choukas NR, Aneja A, Ly TV, Zvolensky MJ, Ditre JW. Nicotine, tobacco smoking, and pain in orthopedic trauma settings: a conceptual framework for practice and research. Arch Orthop Trauma Surg. 2025 Jun 30; 145(1):357.

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Zvolensky MJ, Smit T, Rogers AH, Bakhshaie J, Ditre JW, Rinker DV. Differences in anxiety, depression and pain experience among adults with chronic low back pain as a function of nicotine product use. J Behav Med. 2025 04; 48(2):331-340.

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Doran N, Robledo Gonzalez M, Courtney KE, Wade NE, Pelham W, Patel H, Roesch S, Jacobus J. Social Cognitive Influences Associated With Susceptibility to Nicotine and Tobacco Use in Youth in the Adolescent Brain Cognitive Development (ABCD) Study. J Stud Alcohol Drugs. 2025 Jul; 86(4):521-529.

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Giner P, Ortegon S, Bagdas D, O'Dell LE. The influence of ovarian hormones on the putative mechanisms that promote female nicotine use. Curr Opin Neurobiol. 2024 Oct; 88:102900.

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Ferdous T, Roy S, Chowdhury S, Jebai R, Maya L, DeCaprio AP, Bursac Z, Maziak W. Partial Nicotine Reduction and E-Cigarette Users' Puffing Behaviors Among Adults Aged 21 to 35 Years: A Randomized Crossover Clinical Trial. JAMA Netw Open. 2024 07 01; 7(7):e2422954.

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Yu W, Chen Z, Li Y, Jiang S, Zhang L, Shao XM, Xiao D. In utero chronic intermittent nicotine aerosol exposure increases ischemic heart injury in adult offspring via programming of Angiotensin II receptor-derived TGF?/ROS/Akt signaling pathway. Reprod Toxicol. 2024 09; 128:108650.

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Rivera JC, Espinoza-Derout J, Hasan KM, Molina-Mancio J, Mart?nez J, Lao CJ, Lee ML, Lee DL, Wilson J, Sinha-Hikim AP, Friedman TC. Hepatic steatosis induced by nicotine plus Coca-Cola? is prevented by nicotinamide riboside (NR). Front Endocrinol (Lausanne). 2024; 15:1282231.

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Huang BZ, Binder AM, Quon B, Patel YM, Lum-Jones A, Tiirikainen M, Murphy SE, Loo L, Maunakea AK, Haiman CA, Wilkens LR, Koh WP, Cai Q, Aldrich MC, Siegmund KD, Hecht SS, Yuan JM, Blot WJ, Stram DO, Le Marchand L, Park SL. Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts. Am J Hum Genet. 2024 03 07; 111(3):456-472.

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Kanamori K, Ahmad SM, Hamid A, Lutfy K. Chronic Exposure to E-Cigarettes Elevates CYP2A5 Activity, Protein Expression, and Cotinine-Induced Production of Reactive Oxygen Species in Mice. Drug Metab Dispos. 2024 Feb 14; 52(3):171-179.

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