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Xuesi Max Shao, MD

TitleAssociate Professor
Faculty RankAssociate Professor
InstitutionCharles R. Drew University of Medicine and Science
DepartmentInternal Medicine
Address1731 E. 120th Street
1731 E. 120th Street
Los Angeles CA 90059
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    Collapse Research 
    Collapse research activities and funding
    R43DA031578     (XIE, XINMIN SIMON)Apr 1, 2011 - Jul 31, 2012
    NIH
    Nicotine delivery to rodents with lung alveolar region-targeted aerosol tech
    Role: Co-Principal Investigator
    R44DA031578     (XIE, XINMIN SIMON)Apr 1, 2011 - May 31, 2017
    NIH
    Nicotine delivery to rodent with lung alveolar region-targeted aerosol technology
    Role: Co-Principal Investigator
    R01HL135623     (XIAO, DALIAO)Jan 1, 2017 - Nov 30, 2021
    NIH
    Maternal inhaled nicotine leads to aberrant development of hypertensive phenotype
    Role: Co-Principal Investigator
    R41DA044788     (KEWEKORDES, JOSEF)Feb 1, 2018 - Jun 30, 2019
    NIH
    Developing an efficient E-cigarette aerosol generation and exposure system for rodent models with aerosol characteristics equivalent to those inhaled by E-cigarette users
    Role: Co-Principal Investigator
    R42DA044788     (KEWEKORDES, JOSEF)Feb 1, 2018 - Jun 30, 2021
    NIH
    Developing an efficient E-cigarette aerosol generation and exposure system for rodent models with aerosol characteristics equivalent to those inhaled by E-cigarette users
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yu W, Chen Z, Li Y, Jiang S, Zhang L, Shao XM, Xiao D. In utero chronic intermittent nicotine aerosol exposure increases ischemic heart injury in adult offspring via programming of Angiotensin II receptor-derived TGF?/ROS/Akt signaling pathway. Reprod Toxicol. 2024 Jun 28; 128:108650. PMID: 38945500.
      Citations:    Fields:    
    2. Espinoza-Derout J, Arambulo JML, Ramirez-Trillo W, Rivera JC, Hasan KM, Lao CJ, Jordan MC, Shao XM, Roos KP, Sinha-Hikim AP, Friedman TC. The lipolysis inhibitor acipimox reverses the cardiac phenotype induced by electronic cigarettes. Sci Rep. 2023 10 25; 13(1):18239. PMID: 37880325.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Liu B, Xia L, Li Y, Jiang S, Yu W, Zhang L, Shao XM, Xu Z, Xiao D. Prenatal Nicotine Exposure Raises Male Blood Pressure via FTO-Mediated NOX2/ROS Signaling. Hypertension. 2024 Feb; 81(2):240-251. PMID: 37795601.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Al Omran AJ, Watanabe S, Hong EC, Skinner SG, Zhang M, Zhang J, Shao XM, Liang J. Dihydromyricetin ameliorates social isolation-induced anxiety by modulating mitochondrial function, antioxidant enzymes, and BDNF. Neurobiol Stress. 2022 Nov; 21:100499. PMID: 36532369.
      Citations:    
    5. Watanabe S, Omran AA, Shao AS, Xue C, Zhang Z, Zhang J, Davies DL, Shao XM, Watanabe J, Liang J. Dihydromyricetin improves social isolation-induced cognitive impairments and astrocytic changes in mice. Sci Rep. 2022 04 07; 12(1):5899. PMID: 35393483.
      Citations: 4     Fields:    Translation:AnimalsCells
    6. Espinoza-Derout J, Shao XM, Lao CJ, Hasan KM, Rivera JC, Jordan MC, Echeverria V, Roos KP, Sinha-Hikim AP, Friedman TC. Electronic Cigarette Use and the Risk of Cardiovascular Diseases. Front Cardiovasc Med. 2022; 9:879726. PMID: 35463745.
      Citations:    
    7. Al Omran AJ, Shao AS, Watanabe S, Zhang Z, Zhang J, Xue C, Watanabe J, Davies DL, Shao XM, Liang J. Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them. J Neuroinflammation. 2022 Jan 04; 19(1):2. PMID: 34983568.
      Citations: 17     Fields:    Translation:AnimalsCells
    8. Walayat A, Li Y, Zhang Y, Fu Y, Liu B, Shao XM, Zhang L, Xiao D. Fetal e-cigarette exposure programs a neonatal brain hypoxic-ischemic sensitive phenotype via altering DNA methylation patterns and autophagy signaling pathway. Am J Physiol Regul Integr Comp Physiol. 2021 11 01; 321(5):R791-R801. PMID: 34524928.
      Citations: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    9. Hasan KM, Munoz A, Tumoyan H, Parveen M, Espinoza-Derout J, Shao XM, Mahata SK, Friedman TC, Sinha-Hikim AP. Adverse effects of fetal exposure of electronic-cigarettes and high-fat diet on male neonatal hearts. Exp Mol Pathol. 2021 02; 118:104573. PMID: 33212125.
      Citations: 2     Fields:    Translation:AnimalsCells
    10. Hasan KM, Friedman TC, Parveen M, Espinoza-Derout J, Bautista F, Razipour MM, Shao XM, Jordan MC, Roos KP, Mahata SK, Sinha-Hikim AP. Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice. PLoS One. 2020; 15(10):e0239671. PMID: 33002059.
      Citations: 10     Fields:    Translation:Animals
    11. Jian J, Zhang P, Li Y, Liu B, Zhang Y, Zhang L, Shao XM, Zhuang J, Xiao D. Reprogramming of miR-181a/DNA methylation patterns contribute to the maternal nicotine exposure-induced fetal programming of cardiac ischemia-sensitive phenotype in postnatal life. Theranostics. 2020; 10(25):11820-11836. PMID: 33052248.
      Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    12. Silva J, Shao AS, Shen Y, Davies DL, Olsen RW, Holschneider DP, Shao XM, Liang J. Modulation of Hippocampal GABAergic Neurotransmission and Gephyrin Levels by Dihydromyricetin Improves Anxiety. Front Pharmacol. 2020; 11:1008. PMID: 32742262.
      Citations:    
    13. Shao XM, Friedman TC. Last Word on Viewpoint: pH Buffer capacity and pharmacokinetics: two remaining questions. J Appl Physiol (1985). 2020 04 01; 128(4):1063-1064. PMID: 32284007.
      Citations: 1     Fields:    
    14. Shao XM, Fang ZT. Severe Acute Toxicity of Inhaled Nicotine and e-Cigarettes: Seizures and Cardiac Arrhythmia. Chest. 2020 03; 157(3):506-508. PMID: 32145810.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    15. Zhang P, Li Y, Fu Y, Huang L, Liu B, Zhang L, Shao XM, Xiao D. Inhibition of Autophagy Signaling via 3-methyladenine Rescued Nicotine-Mediated Cardiac Pathological Effects and Heart Dysfunctions. Int J Biol Sci. 2020; 16(8):1349-1362. PMID: 32210724.
      Citations: 7     Fields:    Translation:AnimalsCells
    16. Shao XM, Friedman TC. Pod-mod vs. conventional e-cigarettes: nicotine chemistry, pH, and health effects. J Appl Physiol (1985). 2020 04 01; 128(4):1056-1058. PMID: 31854246.
      Citations: 31     Fields:    
    17. Sun X, Th?rn P?rez C, Halemani D N, Shao XM, Greenwood M, Heath S, Feldman JL, Kam K. Opioids modulate an emergent rhythmogenic process to depress breathing. Elife. 2019 12 16; 8. PMID: 31841107.
      Citations: 25     Fields:    Translation:AnimalsCells
    18. Kao L, Azimov R, Shao XM, Abuladze N, Newman D, Zhekova H, Noskov S, Pushkin A, Kurtz I. SLC4A11 function: evidence for H+(OH-) and NH3-H+ transport. Am J Physiol Cell Physiol. 2020 02 01; 318(2):C392-C405. PMID: 31774702.
      Citations: 9     Fields:    Translation:HumansCells
    19. Shao XM, Lopez B, Nathan D, Wilson J, Bankole E, Tumoyan H, Munoz A, Espinoza-Derout J, Hasan KM, Chang S, Du C, Sinha-Hikim AP, Lutfy K, Friedman TC. A mouse model for chronic intermittent electronic cigarette exposure exhibits nicotine pharmacokinetics resembling human vapers. J Neurosci Methods. 2019 10 01; 326:108376. PMID: 31361999.
      Citations: 22     Fields:    Translation:Animals
    20. Espinoza-Derout J, Hasan KM, Shao XM, Jordan MC, Sims C, Lee DL, Sinha S, Simmons Z, Mtume N, Liu Y, Roos KP, Sinha-Hikim AP, Friedman TC. Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice. Am J Physiol Heart Circ Physiol. 2019 08 01; 317(2):H445-H459. PMID: 31172811.
      Citations: 42     Fields:    Translation:AnimalsCellsPHPublic Health
    21. Espinoza-Derout J, Shao XM, Bankole E, Hasan KM, Mtume N, Liu Y, Sinha-Hikim AP, Friedman TC. Hepatic DNA Damage Induced by Electronic Cigarette Exposure Is Associated With the Modulation of NAD+/PARP1/SIRT1 Axis. Front Endocrinol (Lausanne). 2019; 10:320. PMID: 31214115.
      Citations: 14     Fields:    
    22. Shao XM, Liu S, Lee ES, Fung D, Pei H, Liang J, Mudgway R, Zhang J, Feldman JL, Zhu Y, Louie S, Xie XS. Chronic intermittent nicotine delivery via lung alveolar region-targeted aerosol technology produces circadian pharmacokinetics in rats resembling human smokers. J Appl Physiol (1985). 2018 11 01; 125(5):1555-1562. PMID: 30236046.
      Citations: 5     Fields:    Translation:Animals
    23. Liu Z, Lindemeyer AK, Liang J, Wallner M, Shao XM, Shao Y, Tao Y, Olsen RW. Flavonoids isolated from Tibetan medicines, binding to GABAA receptor and the anticonvulsant activity. Phytomedicine. 2018 Nov 15; 50:1-7. PMID: 30466968.
      Citations: 4     Fields:    Translation:AnimalsCells
    24. Shao XM, L?pez-Vald?s HE, Liang J, Feldman JL. Inhaled nicotine equivalent to cigarette smoking disrupts systemic and uterine hemodynamics and induces cardiac arrhythmia in pregnant rats. Sci Rep. 2017 12 05; 7(1):16974. PMID: 29209071.
      Citations: 18     Fields:    Translation:Animals
    25. Lindemeyer AK, Shen Y, Yazdani F, Shao XM, Spigelman I, Davies DL, Olsen RW, Liang J. a2 Subunit-Containing GABAA Receptor Subtypes Are Upregulated and Contribute to Alcohol-Induced Functional Plasticity in the Rat Hippocampus. Mol Pharmacol. 2017 08; 92(2):101-112. PMID: 28536106.
      Citations: 11     Fields:    Translation:AnimalsCells
    26. Shao XM, Kao L, Kurtz I. A novel delta current method for transport stoichiometry estimation. BMC Biophys. 2014; 7(1):14. PMID: 25558372.
      Citations:    
    27. Liang J, L?pez-Vald?s HE, Mart?nez-Coria H, Lindemeyer AK, Shen Y, Shao XM, Olsen RW. Dihydromyricetin ameliorates behavioral deficits and reverses neuropathology of transgenic mouse models of Alzheimer's disease. Neurochem Res. 2014 Jun; 39(6):1171-81. PMID: 24728903.
      Citations: 34     Fields:    Translation:Animals
    28. Liang J, Lindemeyer AK, Suryanarayanan A, Meyer EM, Marty VN, Ahmad SO, Shao XM, Olsen RW, Spigelman I. Plasticity of GABA(A) receptor-mediated neurotransmission in the nucleus accumbens of alcohol-dependent rats. J Neurophysiol. 2014 Jul 01; 112(1):39-50. PMID: 24694935.
      Citations: 12     Fields:    Translation:AnimalsCells
    29. Liang J, Shen Y, Shao XM, Scott MB, Ly E, Wong S, Nguyen A, Tan K, Kwon B, Olsen RW, Spigelman I. Dihydromyricetin prevents fetal alcohol exposure-induced behavioral and physiological deficits: the roles of GABAA receptors in adolescence. Neurochem Res. 2014 Jun; 39(6):1147-61. PMID: 24676702.
      Citations: 19     Fields:    Translation:Animals
    30. Zhu Q, Shao XM, Kao L, Azimov R, Weinstein AM, Newman D, Liu W, Kurtz I. Missense mutation T485S alters NBCe1-A electrogenicity causing proximal renal tubular acidosis. Am J Physiol Cell Physiol. 2013 Aug 15; 305(4):C392-405. PMID: 23636456.
      Citations: 22     Fields:    Translation:HumansCells
    31. Shao XM, Xu B, Liang J, Xie XS, Zhu Y, Feldman JL. Nicotine delivery to rats via lung alveolar region-targeted aerosol technology produces blood pharmacokinetics resembling human smoking. Nicotine Tob Res. 2013 Jul; 15(7):1248-58. PMID: 23239844.
      Citations: 18     Fields:    Translation:HumansAnimals
    32. Kao L, Abuladze N, Shao XM, McKeegan K, Kurtz I. A new technique for multiple re-use of planar patch clamp chips. J Neurosci Methods. 2012 Jul 15; 208(2):205-10. PMID: 22609774.
      Citations: 4     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    33. Tan W, Sherman D, Turesson J, Shao XM, Janczewski WA, Feldman JL. Reelin demarcates a subset of pre-B?tzinger complex neurons in adult rat. J Comp Neurol. 2012 Feb 15; 520(3):606-19. PMID: 21858819.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    34. Shen Y, Lindemeyer AK, Gonzalez C, Shao XM, Spigelman I, Olsen RW, Liang J. Dihydromyricetin as a novel anti-alcohol intoxication medication. J Neurosci. 2012 Jan 04; 32(1):390-401. PMID: 22219299.
      Citations: 82     Fields:    Translation:Animals
    35. Shao XM, Feldman JL. Central cholinergic regulation of respiration: nicotinic receptors. Acta Pharmacol Sin. 2009 Jun; 30(6):761-70. PMID: 19498418.
      Citations: 29     Fields:    Translation:HumansAnimals
    36. Tan W, Janczewski WA, Yang P, Shao XM, Callaway EM, Feldman JL. Silencing preB?tzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat. Nat Neurosci. 2008 May; 11(5):538-40. PMID: 18391943.
      Citations: 168     Fields:    Translation:AnimalsCells
    37. Shao XM, Tan W, Xiu J, Puskar N, Fonck C, Lester HA, Feldman JL. Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm. J Neurosci. 2008 Jan 09; 28(2):519-28. PMID: 18184794.
      Citations: 27     Fields:    Translation:AnimalsCells
    38. Shao XM, Feldman JL. Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC. J Neurosci Methods. 2007 Mar 15; 160(2):256-63. PMID: 17092561.
      Citations: 4     Fields:    Translation:AnimalsCells
    39. Shao XM, Feldman JL. Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials. J Neurosci Methods. 2007 Jan 15; 159(1):108-15. PMID: 16916545.
      Citations: 18     Fields:    Translation:Cells
    40. Feng JM, Hu YK, Xie LH, Colwell CS, Shao XM, Sun XP, Chen B, Tang H, Campagnoni AT. Golli protein negatively regulates store depletion-induced calcium influx in T cells. Immunity. 2006 Jun; 24(6):717-727. PMID: 16782028.
      Citations: 44     Fields:    Translation:AnimalsCells
    41. Shao XM, Ge Q, Feldman JL. Modulation of AMPA receptors by cAMP-dependent protein kinase in preB?tzinger complex inspiratory neurons regulates respiratory rhythm in the rat. J Physiol. 2003 Mar 01; 547(Pt 2):543-53. PMID: 12562968.
      Citations: 19     Fields:    Translation:AnimalsCells
    42. Shao XM, Feldman JL. Pharmacology of nicotinic receptors in preB?tzinger complex that mediate modulation of respiratory pattern. J Neurophysiol. 2002 Oct; 88(4):1851-8. PMID: 12364511.
      Citations: 18     Fields:    Translation:Animals
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