Fibrinogen

"Fibrinogen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.

Descriptor ID	D005340
MeSH Number(s)	D12.776.124.050.250 D12.776.124.125.500 D12.776.811.300 D23.119.490
Concept/Terms	Fibrinogen Fibrinogen Blood Coagulation Factor I Coagulation Factor I Factor I, Coagulation Factor I gamma-Fibrinogen gamma-Fibrinogen gamma Fibrinogen

Below are MeSH descriptors whose meaning is more general than "Fibrinogen".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Acute-Phase Proteins [D12.776.124.050]
Fibrinogen [D12.776.124.050.250]
Blood Coagulation Factors [D12.776.124.125]
Fibrinogen [D12.776.124.125.500]
Protein Precursors [D12.776.811]
Fibrinogen [D12.776.811.300]
Biological Factors [D23]
Blood Coagulation Factors [D23.119]
Fibrinogen [D23.119.490]

Below are MeSH descriptors whose meaning is related to "Fibrinogen".

Below are MeSH descriptors whose meaning is more specific than "Fibrinogen".

Fibrinogen
Fibrinogens, Abnormal

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Fibrinogen" by people in this website by year, and whether "Fibrinogen" was a major or minor topic of these publications.

Bar chart showing 21 publications over 14 distinct years, with a maximum of 3 publications in 2009 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	0	1
2004	0	2	2
2006	0	1	1
2007	0	1	1
2009	0	3	3
2011	1	0	1
2014	2	1	3
2016	0	1	1
2017	1	1	2
2018	0	1	1
2020	1	0	1
2021	0	1	1
2022	0	2	2
2023	0	1	1

Below are the most recent publications written about "Fibrinogen" by people in Profiles.

Church KA, Rodriguez D, Mendiola AS, Vanegas D, Gutierrez IL, Tamayo I, Amadu A, Velazquez P, Cardona SM, Gyoneva S, Cotleur AC, Ransohoff RM, Kaur T, Cardona AE. Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1I249/M280-expressing retina. Front Immunol. 2023; 14:1130735.

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Church KA, Rodriguez D, Vanegas D, Gutierrez IL, Cardona SM, Madrigal JLM, Kaur T, Cardona AE. Models of microglia depletion and replenishment elicit protective effects to alleviate vascular and neuronal damage in the diabetic murine retina. J Neuroinflammation. 2022 Dec 14; 19(1):300.

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Sarker B, Cardona SM, Church KA, Vanegas D, Velazquez P, Rorex C, Rodriguez D, Mendiola AS, Kern TS, Domingo ND, Stephens R, Muzzio IA, Cardona AE. Defibrinogenation Ameliorates Retinal Microgliosis and Inflammation in A CX3CR1-Independent Manner. ASN Neuro. 2022 Jan-Dec; 14:17590914221131446.

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Borges-V?lez G, Rosado-Philippi J, Cantres-Rosario YM, Carrasquillo-Carrion K, Roche-Lima A, P?rez-Vargas J, Gonz?lez-Mart?nez A, Correa-Rivas MS, Mel?ndez LM. Zika virus infection of the placenta alters extracellular matrix proteome. J Mol Histol. 2022 Apr; 53(2):199-214.

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Martini WZ, Rodriguez CM, Cap AP, Dubick MA. Efficacy of resuscitation with fibrinogen concentrate and platelets in traumatic hemorrhage swine model. J Trauma Acute Care Surg. 2020 08; 89(2S Suppl 2):S137-S145.

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Chen H, Huffman JE, Brody JA, Wang C, Lee S, Li Z, Gogarten SM, Sofer T, Bielak LF, Bis JC, Blangero J, Bowler RP, Cade BE, Cho MH, Correa A, Curran JE, de Vries PS, Glahn DC, Guo X, Johnson AD, Kardia S, Kooperberg C, Lewis JP, Liu X, Mathias RA, Mitchell BD, O'Connell JR, Peyser PA, Post WS, Reiner AP, Rich SS, Rotter JI, Silverman EK, Smith JA, Vasan RS, Wilson JG, Yanek LR, Redline S, Smith NL, Boerwinkle E, Borecki IB, Cupples LA, Laurie CC, Morrison AC, Rice KM, Lin X. Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies. Am J Hum Genet. 2019 02 07; 104(2):260-274.

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Wilson KD, Ochoa LF, Solomon OD, Pal R, Cardona SM, Carpio VH, Keiser PH, Cardona AE, Vargas G, Stephens R. Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria. J Neuroinflammation. 2018 Jun 04; 15(1):173.

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Martini WZ, Rodriguez CM, Richardson J, Aden JK, Cap AP, Dubick MA. Physiological Impact of Platelet Apheresis in Pigs: Oxygen Metabolism and Coagulation. Mil Med. 2017 03; 182(S1):195-201.

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Kim CH, McBride DW, Raval R, Sherchan P, Hay KL, Gren EC, Kelln W, Lekic T, Hayes WK, Bull BS, Applegate R, Tang J, Zhang JH. Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury. Sci Rep. 2017 01 19; 7:40821.

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Barger SD, Cribbet MR, Muldoon MF. Participant-Reported Health Status Predicts Cardiovascular and All-Cause Mortality Independent of Established and Nontraditional Biomarkers: Evidence From a Representative US Sample. J Am Heart Assoc. 2016 08 29; 5(9).

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