Chemokine CX3CL1

"Chemokine CX3CL1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A CX3C chemokine that is a transmembrane protein found on the surface of cells. The soluble form of chemokine CX3CL1 can be released from cell surface by proteolysis and act as a chemoattractant that may be involved in the extravasation of leukocytes into inflamed tissues. The membrane form of the protein may also play a role in cell adhesion.

Descriptor ID	D054428
MeSH Number(s)	D12.644.276.374.200.130.500 D12.776.467.374.200.130.500 D12.776.543.193 D23.125.300.130.500 D23.469.200.130.500 D23.529.374.200.130.500
Concept/Terms	Chemokine CX3CL1 Chemokine CX3CL1 CX3CL1, Chemokine CX3CL1 Chemokine Chemokine, CX3CL1 Neurotactin Chemokine (C-X3-C Motif) Ligand 1 Fractalkine

Below are MeSH descriptors whose meaning is more general than "Chemokine CX3CL1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Chemokines [D12.644.276.374.200]
Chemokines, CX3C [D12.644.276.374.200.130]
Chemokine CX3CL1 [D12.644.276.374.200.130.500]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Chemokines [D12.776.467.374.200]
Chemokines, CX3C [D12.776.467.374.200.130]
Chemokine CX3CL1 [D12.776.467.374.200.130.500]
Membrane Proteins [D12.776.543]
Chemokine CX3CL1 [D12.776.543.193]
Biological Factors [D23]
Chemotactic Factors [D23.125]
Chemokines [D23.125.300]
Chemokines, CX3C [D23.125.300.130]
Chemokine CX3CL1 [D23.125.300.130.500]
Inflammation Mediators [D23.469]
Chemokines [D23.469.200]
Chemokines, CX3C [D23.469.200.130]
Chemokine CX3CL1 [D23.469.200.130.500]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Chemokines [D23.529.374.200]
Chemokines, CX3C [D23.529.374.200.130]
Chemokine CX3CL1 [D23.529.374.200.130.500]

Below are MeSH descriptors whose meaning is related to "Chemokine CX3CL1".

Below are MeSH descriptors whose meaning is more specific than "Chemokine CX3CL1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Chemokine CX3CL1" by people in this website by year, and whether "Chemokine CX3CL1" was a major or minor topic of these publications.

Bar chart showing 12 publications over 10 distinct years, with a maximum of 2 publications in 2008 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	0	1	1
2008	0	2	2
2010	0	1	1
2015	1	0	1
2018	1	0	1
2019	0	1	1
2021	1	0	1
2022	0	1	1
2023	0	1	1
2024	2	0	2

Below are the most recent publications written about "Chemokine CX3CL1" by people in Profiles.

Rodriguez D, Church KA, Pietramale AN, Cardona SM, Vanegas D, Rorex C, Leary MC, Muzzio IA, Nash KR, Cardona AE. Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina. J Neuroinflammation. 2024 Feb 04; 21(1):42.

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Rodriguez D, Church KA, Smith CT, Vanegas D, Cardona SM, Muzzio IA, Nash KR, Cardona AE. Therapeutic Delivery of Soluble Fractalkine Ameliorates Vascular Dysfunction in the Diabetic Retina. Int J Mol Sci. 2024 Jan 31; 25(3).

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Charlton JR, Li T, Wu T, deRonde K, Xu Y, Baldelomar EJ, Bennett KM. Use of novel structural features to identify urinary biomarkers during acute kidney injury that predict progression to chronic kidney disease. BMC Nephrol. 2023 06 19; 24(1):178.

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Mendiola AS, Church KA, Cardona SM, Vanegas D, Garcia SA, Macklin W, Lira SA, Ransohoff RM, Kokovay E, Lin CA, Cardona AE. Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination. J Neurochem. 2022 09; 162(5):430-443.

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Watson AES, de Almeida MMA, Dittmann NL, Li Y, Torabi P, Footz T, Vetere G, Galleguillos D, Sipione S, Cardona AE, Voronova A. Fractalkine signaling regulates oligodendroglial cell genesis from SVZ precursor cells. Stem Cell Reports. 2021 08 10; 16(8):1968-1984.

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Singh SK, Mishra MK, Singh R. Hypoxia-inducible factor-1a induces CX3CR1 expression and promotes the epithelial to mesenchymal transition (EMT) in ovarian cancer cells. J Ovarian Res. 2019 May 10; 12(1):42.

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Bemiller SM, Maphis NM, Formica SV, Wilson GN, Miller CM, Xu G, Kokiko-Cochran ON, Kim KW, Jung S, Cannon JL, Crish SD, Cardona AE, Lamb BT, Bhaskar K. Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy. J Neuroinflammation. 2018 Sep 25; 15(1):278.

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Cardona SM, Mendiola AS, Yang YC, Adkins SL, Torres V, Cardona AE. Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina. ASN Neuro. 2015 Sep-Oct; 7(5).

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Lee S, Varvel NH, Konerth ME, Xu G, Cardona AE, Ransohoff RM, Lamb BT. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. Am J Pathol. 2010 Nov; 177(5):2549-62.

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Blum DL, Koyama T, M'Koma AE, Iturregui JM, Martinez-Ferrer M, Uwamariya C, Smith JA, Clark PE, Bhowmick NA. Chemokine markers predict biochemical recurrence of prostate cancer following prostatectomy. Clin Cancer Res. 2008 Dec 01; 14(23):7790-7.

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