Dystrophin

"Dystrophin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.

Descriptor ID	D016189
MeSH Number(s)	D12.776.210.500.250 D12.776.220.250 D12.776.543.250
Concept/Terms	Dystrophin Dystrophin

Below are MeSH descriptors whose meaning is more general than "Dystrophin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Contractile Proteins [D12.776.210]
Muscle Proteins [D12.776.210.500]
Dystrophin [D12.776.210.500.250]
Cytoskeletal Proteins [D12.776.220]
Dystrophin [D12.776.220.250]
Membrane Proteins [D12.776.543]
Dystrophin [D12.776.543.250]

Below are MeSH descriptors whose meaning is related to "Dystrophin".

Below are MeSH descriptors whose meaning is more specific than "Dystrophin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Dystrophin" by people in this website by year, and whether "Dystrophin" was a major or minor topic of these publications.

Bar chart showing 17 publications over 15 distinct years, with a maximum of 2 publications in 1995 and 2001

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	0	1
1995	2	0	2
1996	1	0	1
1997	0	1	1
1999	1	0	1
2001	2	0	2
2002	1	0	1
2003	1	0	1
2005	1	0	1
2009	1	0	1
2011	0	1	1
2013	0	1	1
2016	1	0	1
2017	0	1	1
2022	0	1	1

Below are the most recent publications written about "Dystrophin" by people in Profiles.

Sakai K, Motegi T, Chambers JK, Uchida K, Nishida H, Shimamura S, Tani H, Shimada T, Furuya M. Dystrophin-deficient muscular dystrophy in a Toy Poodle with a single base pair insertion in exon 45 of the Duchenne muscular dystrophy gene. J Vet Med Sci. 2022 Apr 13; 84(4):502-506.

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Doe J, Kaindl AM, Jijiwa M, de la Vega M, Hu H, Griffiths GS, Fontelonga TM, Barraza P, Cruz V, Van Ry P, Ramos JW, Burkin DJ, Matter ML. PTRH2 gene mutation causes progressive congenital skeletal muscle pathology. Hum Mol Genet. 2017 04 15; 26(8):1458-1464.

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Ramos E, Conde JG, Berrios RA, Pardo S, G?mez O, Mas Rodr?guez MF. Prevalence and Genetic Profile of Duchene and Becker Muscular Dystrophy in Puerto Rico. J Neuromuscul Dis. 2016 05 27; 3(2):261-266.

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Tsao J, Vernet DA, Gelfand R, Kovanecz I, Nolazco G, Bruhn KW, Gonzalez-Cadavid NF. Myostatin genetic inactivation inhibits myogenesis by muscle-derived stem cells in vitro but not when implanted in the mdx mouse muscle. Stem Cell Res Ther. 2013 Jan 07; 4(1):4.

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Zhou YW, Munoz J, Jiang D, Jarrett HW. Laminin-a1 LG4-5 domain binding to dystroglycan mediates muscle cell survival, growth, and the AP-1 and NF-?B transcription factors but also has adverse effects. Am J Physiol Cell Physiol. 2012 Mar 15; 302(6):C902-14.

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Xiong Y, Zhou Y, Jarrett HW. Dystrophin glycoprotein complex-associated Gbetagamma subunits activate phosphatidylinositol-3-kinase/Akt signaling in skeletal muscle in a laminin-dependent manner. J Cell Physiol. 2009 May; 219(2):402-14.

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Etard C, Behra M, Ertzer R, Fischer N, Jesuthasan S, Blader P, Geisler R, Str?hle U. Mutation in the delta-subunit of the nAChR suppresses the muscle defects caused by lack of Dystrophin. Dev Dyn. 2005 Dec; 234(4):1016-25.

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Oak SA, Zhou YW, Jarrett HW. Skeletal muscle signaling pathway through the dystrophin glycoprotein complex and Rac1. J Biol Chem. 2003 Oct 10; 278(41):39287-95.

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Chockalingam PS, Cholera R, Oak SA, Zheng Y, Jarrett HW, Thomason DB. Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy. Am J Physiol Cell Physiol. 2002 Aug; 283(2):C500-11.

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Bola?os-Jim?nez F, Bordais A, Behra M, Str?hle U, Mornet D, Sahel J, Rend?n A. Molecular cloning and characterization of dystrophin and Dp71, two products of the Duchenne Muscular Dystrophy gene, in zebrafish. Gene. 2001 Aug 22; 274(1-2):217-26.

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