Trypsin Inhibitor, Kazal Pancreatic
"Trypsin Inhibitor, Kazal Pancreatic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premataure activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS.
| Descriptor ID |
D014359
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| MeSH Number(s) |
D12.644.822.750.500 D12.776.124.050.850 D12.776.645.688.500
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| Concept/Terms |
Trypsin Inhibitor, Kazal Pancreatic- Trypsin Inhibitor, Kazal Pancreatic
- Serine Protease Inhibitor Kazal-Type 1
- Serine Protease Inhibitor Kazal Type 1
- Pancreatic Secretory Trypsin Inhibitor
- SPINK1
- Trypsin Inhibitor Kazal Pancreatic
- Pancreatic Trypsin Secretory Inhibitor, Kazal
- Inhibitor, Tumor-Associated Trypsin
- Inhibitor, Tumor Associated Trypsin
- Trypsin Inhibitor, Tumor-Associated
- Trypsin Inhibitor, Tumor Associated
- Tumor-Associated Trypsin Inhibitor
- Tumor Associated Trypsin Inhibitor
- Acidic Pancreatic Trypsin Inhibitor
- Pancreatic Secretory Trypsin Inhibitor, Kazal
- Serine Peptidase Inhibitor, Kazal-Type 1
- Serine Peptidase Inhibitor, Kazal Type 1
- Kazal Pancreatic Trypsin Inhibitor
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Below are MeSH descriptors whose meaning is more general than "Trypsin Inhibitor, Kazal Pancreatic".
Below are MeSH descriptors whose meaning is more specific than "Trypsin Inhibitor, Kazal Pancreatic".
This graph shows the total number of publications written about "Trypsin Inhibitor, Kazal Pancreatic" by people in this website by year, and whether "Trypsin Inhibitor, Kazal Pancreatic" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Trypsin Inhibitor, Kazal Pancreatic" by people in Profiles.
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Beyene DA, Naab TJ, Kanarek NF, Apprey V, Esnakula A, Khan FA, Blackman MR, Brown CA, Hudson TS. Differential expression of Annexin 2, SPINK1, and Hsp60 predict progression of prostate cancer through bifurcated WHO Gleason score categories in African American men. Prostate. 2018 08; 78(11):801-811.
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Winchester D, Ricks-Santi L, Mason T, Abbas M, Copeland RL, Beyene D, Jingwi EY, Dunston GM, Kanaan YM. SPINK1 Promoter Variants Are Associated with Prostate Cancer Predisposing Alterations in Benign Prostatic Hyperplasia Patients. Anticancer Res. 2015 Jul; 35(7):3811-9.
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Felderbauer P, Hoffmann P, Einw?chter H, Bulut K, Ansorge N, Schmitz F, Schmidt WE. A novel mutation of the calcium sensing receptor gene is associated with chronic pancreatitis in a family with heterozygous SPINK1 mutations. BMC Gastroenterol. 2003 Nov 29; 3:34.