Complement C3

"Complement C3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.

Descriptor ID	D003176
MeSH Number(s)	D12.776.124.050.140 D12.776.124.486.274.250
Concept/Terms	Complement C3 Complement C3 C3, Complement Complement 3 Complement Component 3 Component 3, Complement C3 Complement Complement, C3 Complement C3 Precursor Complement C3 Precursor C3 Precursor, Complement Precursor, Complement C3 Pro-C3 Pro C3 Precursor-Complement 3 Precursor Complement 3 Pro-Complement 3 Pro Complement 3 C3 Precursor Precursor, C3

Below are MeSH descriptors whose meaning is more general than "Complement C3".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Acute-Phase Proteins [D12.776.124.050]
Complement C3 [D12.776.124.050.140]
Immunoproteins [D12.776.124.486]
Complement System Proteins [D12.776.124.486.274]
Complement C3 [D12.776.124.486.274.250]

Below are MeSH descriptors whose meaning is more specific than "Complement C3".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Complement C3" by people in this website by year, and whether "Complement C3" was a major or minor topic of these publications.

Bar chart showing 12 publications over 9 distinct years, with a maximum of 3 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	0	1	1
2008	1	0	1
2009	1	0	1
2011	2	1	3
2012	1	1	2
2015	1	0	1
2016	1	0	1
2019	1	0	1
2020	0	1	1

Below are the most recent publications written about "Complement C3" by people in Profiles.

Hew BE, Pangburn MK, Vogel CW, Fritzinger DC. Identification of intermolecular bonds between human factor B and Cobra Venom Factor important for C3 convertase stability. Toxicon. 2020 Sep; 184:68-77.

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Hew BE, Fritzinger DC, Pangburn MK, Vogel CW. Identification of functionally important amino acid sequences in cobra venom factor using human C3/Cobra venom factor hybrid proteins. Toxicon. 2019 Sep; 167:106-116.

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Laskowski J, Renner B, Le Quintrec M, Panzer S, Hannan JP, Ljubanovic D, Ruseva MM, Borza DB, Antonioli AH, Pickering MC, Holers VM, Thurman JM. Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury. Kidney Int. 2016 07; 90(1):109-22.

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Zuo S, Li W, Li Q, Zhao H, Tang J, Chen Q, Liu X, Zhang JH, Chen Y, Feng H. Protective effects of Ephedra sinica extract on blood-brain barrier integrity and neurological function correlate with complement C3 reduction after subarachnoid hemorrhage in rats. Neurosci Lett. 2015 Nov 16; 609:216-22.

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Hew BE, Wehrhahn D, Fritzinger DC, Vogel CW. Hybrid proteins of Cobra Venom Factor and cobra C3: tools to identify functionally important regions in Cobra Venom Factor. Toxicon. 2012 Sep 15; 60(4):632-47.

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Zhang JJ, Malekpour M, Luo W, Ge L, Olaru F, Wang XP, Bah M, Sado Y, Heidet L, Kleinau S, Fogo AB, Borza DB. Murine membranous nephropathy: immunization with a3(IV) collagen fragment induces subepithelial immune complexes and Fc?R-independent nephrotic syndrome. J Immunol. 2012 Apr 01; 188(7):3268-77.

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Aihara N, Chambers JK, Hosono K, Kamiie J, Shirota K. An experimental type II mixed cryoglobulinemia with renal glomerulopathy in ICR mice triggered by Capillaria hepatica infection. Histol Histopathol. 2011 12; 26(12):1519-29.

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Ruiz LA, Dutil J, Ruiz A, Fourquet J, Abac S, Laboy J, Flores I. Single-nucleotide polymorphisms in the lysyl oxidase-like protein 4 and complement component 3 genes are associated with increased risk for endometriosis and endometriosis-associated infertility. Fertil Steril. 2011 Aug; 96(2):512-5.

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L?pez de Victoria A, Gorham RD, Bellows-Peterson ML, Ling J, Lo DD, Floudas CA, Morikis D. A new generation of potent complement inhibitors of the Compstatin family. Chem Biol Drug Des. 2011 Jun; 77(6):431-40.

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Fritzinger DC, Hew BE, Thorne M, Pangburn MK, Janssen BJ, Gros P, Vogel CW. Functional characterization of human C3/cobra venom factor hybrid proteins for therapeutic complement depletion. Dev Comp Immunol. 2009; 33(1):105-16.

View in: PubMed

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