Fibrinolysin

"Fibrinolysin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.

Descriptor ID	D005341
MeSH Number(s)	D08.811.277.656.300.760.330 D08.811.277.656.959.350.330
Concept/Terms	Fibrinolysin Fibrinolysin Plasmin Protease F Glu-Plasmin Glu Plasmin Fibrogammin Fibrogammin Thrombolysin Thrombolysin

Below are MeSH descriptors whose meaning is more general than "Fibrinolysin".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Serine Endopeptidases [D08.811.277.656.300.760]
Fibrinolysin [D08.811.277.656.300.760.330]
Serine Proteases [D08.811.277.656.959]
Serine Endopeptidases [D08.811.277.656.959.350]
Fibrinolysin [D08.811.277.656.959.350.330]

Below are MeSH descriptors whose meaning is more specific than "Fibrinolysin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Fibrinolysin" by people in this website by year, and whether "Fibrinolysin" was a major or minor topic of these publications.

Bar chart showing 9 publications over 8 distinct years, with a maximum of 2 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2000	0	1	1
2002	0	1	1
2004	1	0	1
2006	0	1	1
2014	0	1	1
2016	0	2	2
2025	1	0	1

Below are the most recent publications written about "Fibrinolysin" by people in Profiles.

Wamba BEN, Mondal T, Freenor V F, Shaheed M, Pang O, Bedinger D, Legembre P, Devel L, Bhatnagar S, Leiserowitz GS, Tushir-Singh J. Evolutionary regulation of human Fas ligand (CD95L) by plasmin in solid cancer immunotherapy. Nat Commun. 2025 Jul 01; 16(1):5748.

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Yang P, Manaenko A, Xu F, Miao L, Wang G, Hu X, Guo ZN, Hu Q, Hartman RE, Pearce WJ, Obenaus A, Zhang JH, Chen G, Tang J. Role of PDGF-D and PDGFR-? in neuroinflammation in experimental ICH mice model. Exp Neurol. 2016 09; 283(Pt A):157-64.

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Yang P, Wu J, Miao L, Manaenko A, Matei N, Zhang Y, Xu L, Pearce WJ, Hartman RE, Obenaus A, Zhang JH, Xu F, Tang J. Platelet-Derived Growth Factor Receptor-? Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice. Crit Care Med. 2016 06; 44(6):e390-402.

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Moon HG, Kim SH, Gao J, Quan T, Qin Z, Osorio JC, Rosas IO, Wu M, Tesfaigzi Y, Jin Y. CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke. Am J Physiol Lung Cell Mol Physiol. 2014 Aug 15; 307(4):L326-37.

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Yin S, Lockett J, Meng Y, Biliran H, Blouse GE, Li X, Reddy N, Zhao Z, Lin X, Anagli J, Cher ML, Sheng S. Maspin retards cell detachment via a novel interaction with the urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor system. Cancer Res. 2006 Apr 15; 66(8):4173-81.

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Jones MN, Holt RG. Activation of plasminogen by Streptococcus mutans. Biochem Biophys Res Commun. 2004 Sep 10; 322(1):37-41.

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Chipuk JE, Stewart LV, Ranieri A, Song K, Danielpour D. Identification and characterization of a novel rat ov-serpin family member, trespin. J Biol Chem. 2002 Jul 19; 277(29):26412-21.

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McGowen R, Biliran H, Sager R, Sheng S. The surface of prostate carcinoma DU145 cells mediates the inhibition of urokinase-type plasminogen activator by maspin. Cancer Res. 2000 Sep 01; 60(17):4771-8.

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Yehualaeshet T, O'Connor R, Green-Johnson J, Mai S, Silverstein R, Murphy-Ullrich JE, Khalil N. Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36. Am J Pathol. 1999 Sep; 155(3):841-51.

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