"Proprotein Convertase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CALCIUM-dependent endopeptidase that has specificity for cleavage at ARGININE that is near paired basic residues. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN; PRORENIN; proenkephalins; prodynorphin; prosomatostatin; and PROINSULIN.
| Descriptor ID |
D045664
|
| MeSH Number(s) |
D08.811.277.656.300.760.640 D08.811.277.656.837.500 D08.811.277.656.959.350.640
|
| Concept/Terms |
Proprotein Convertase 1- Proprotein Convertase 1
- Convertase 1, Proprotein
- PC1 Prohormone Convertase
- PC3 Endoprotease
- Endoprotease, PC3
- PC3 Prohormone Convertase
- Convertase, PC3 Prohormone
- Prohormone Convertase, PC3
- Neuroendocrine Convertase PC1
- Convertase PC1, Neuroendocrine
- Proprotein Convertase SPC3
- Convertase SPC3, Proprotein
- Proinsulin Convertase 1
- Prohormone Convertase 3
- Prohormone Convertase, PC1
- Convertase, PC1 Prohormone
- PC1 Endoprotease
- Endoprotease, PC1
- Prohormone Convertase 1
|
Below are MeSH descriptors whose meaning is more general than "Proprotein Convertase 1".
Below are MeSH descriptors whose meaning is more specific than "Proprotein Convertase 1".
This graph shows the total number of publications written about "Proprotein Convertase 1" by people in this website by year, and whether "Proprotein Convertase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2008 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proprotein Convertase 1" by people in Profiles.
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Nie Y, Ferrini MG, Liu Y, Anghel A, Paez Espinosa EV, Stuart RC, Lutfy K, Nillni EA, Friedman TC. Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2. Peptides. 2013 Sep; 47:99-109.
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Kilimnik G, Kim A, Steiner DF, Friedman TC, Hara M. Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic a-cells in mouse models of ?-cell regeneration. Islets. 2010 May-Jun; 2(3):149-55.
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Espinosa VP, Liu Y, Ferrini M, Anghel A, Nie Y, Tripathi PV, Porche R, Jansen E, Stuart RC, Nillni EA, Lutfy K, Friedman TC. Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction. Neuroscience. 2008 Oct 15; 156(3):788-99.
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Espinosa VP, Ferrini M, Shen X, Lutfy K, Nillni EA, Friedman TC. Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E175-86.
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Perello M, Friedman T, Paez-Espinosa V, Shen X, Stuart RC, Nillni EA. Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus. Endocrinology. 2006 Jun; 147(6):2705-16.
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Hardiman A, Friedman TC, Grunwald WC, Furuta M, Zhu Z, Steiner DF, Cool DR. Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry. J Mol Endocrinol. 2005 Jun; 34(3):739-51.
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Sanchez VC, Goldstein J, Stuart RC, Hovanesian V, Huo L, Munzberg H, Friedman TC, Bjorbaek C, Nillni EA. Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone. J Clin Invest. 2004 Aug; 114(3):357-69.