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Xinbin Gu

TitleProfessor
Faculty RankProfessor
InstitutionHoward University
DepartmentOral Pathology
Address600 W Street, NW.
Room 210
Washington DC 20059
Phone2028060345
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    Collapse Research 
    Collapse research activities and funding
    P20CA118770     (GU, XINBIN)Sep 30, 2005 - Aug 31, 2010
    NIH
    HU/JHU Head and Neck Cancer Translational Research and *
    Role: Principal Investigator
    R15DE025138     (SHAN, LIANG)Aug 15, 2015 - Jul 31, 2019
    NIH
    Humanized EGFR and EGFRvlll-bispecific Immunotoxin for HNSCC Therapy
    Role: Co-Principal Investigator
    R25DE025778     (GU, XINBIN)Jan 1, 2016 - Dec 31, 2020
    NIH
    Howard University Summer Research Experience Program in Oral Health Disparity for Underrepresented Racial and Ethnic Students
    Role: Principal Investigator
    R25DE032527     (GU, XINBIN)Jan 1, 2023 - Dec 31, 2028
    NIH
    Howard University Summer Research Education Experience Program in Oral Health
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sobitan A, Gebremedhin B, Yao Q, Xie G, Gu X, Li J, Teng S. A Computational Approach: The Functional Effects of Thyroid Peroxidase Variants in Thyroid Cancer and Genetic Disorders. JCO Clin Cancer Inform. 2024 01; 8:e2300140. PMID: 38295322.
      Citations:    Fields:    Translation:HumansPHPublic Health
    2. Xie G, Shan L, Yang C, Liu Y, Pang X, Teng S, Wu TC, Gu X. Recombinant immunotoxin induces tumor intrinsic STING signaling against head and neck squamous cell carcinoma. Sci Rep. 2023 10 28; 13(1):18476. PMID: 37898690.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Cherry-Peppers G, Fryer C, Jackson AD, Gu X, Ford D, Glascoe A, Smith D, Liu M, Dunmore-Griffith J, Robinson-Warner G, McIntosh C, Sonnier J, Slade L, Rizkalla A, Mundey S, Dawson N, Fleurinord M, Edmonson B, Ford C, Griffith J, Peppers G, Muttanahally K, Mncube-Barnes F, Watkins-Bryant T. Sickle cell disease: Contributing factors and radiological assessments. J Natl Med Assoc. 2023 Jul 24. PMID: 37495445.
      Citations:    Fields:    
    4. Liu M, Kao D, Gu X, Holland W, Cherry-Peppers G. Oral Health Service Access in Racial/Ethnic Minority Neighborhoods: A Geospatial Analysis in Washington, DC, USA. Int J Environ Res Public Health. 2022 04 20; 19(9). PMID: 35564382.
      Citations: 2     Fields:    Translation:Humans
    5. Xie G, Gu X. Bidirectional CART.BiTE cells bring new hope. Nat Rev Cancer. 2022 Apr; 22(4):194. PMID: 35110731.
      Citations: 1     Fields:    
    6. Xie G, Zhu A, Gu X. Converged DNA Damage Response Renders Human Hepatocellular Carcinoma Sensitive to CDK7 Inhibition. Cancers (Basel). 2022 Mar 28; 14(7). PMID: 35406486.
      Citations:    
    7. Xie G, Shan L, Liu Y, Wu TC, Gu X. Antitumor Efficacy of EGFR-Targeted Recombinant Immunotoxin in Human Head and Neck Squamous Cell Carcinoma. Biology (Basel). 2022 Mar 22; 11(4). PMID: 35453686.
      Citations:    
    8. Xie G, Zhu A, Gu X. Mitogen-activated protein kinase inhibition-induced modulation of epidermal growth factor receptor signaling in human head and neck squamous cell carcinoma. Head Neck. 2021 06; 43(6):1721-1729. PMID: 33533173.
      Citations: 3     Fields:    Translation:HumansCells
    9. Lin X, Sajith AM, Wang S, Kumari N, Choy MS, Ahmad A, Cadet DR, Gu X, Ivanov AI, Peti W, Kulkarni A, Nekhai S. Structural Optimization of 2,3-Dihydro-1H-cyclopenta[b]quinolines Targeting the Noncatalytic RVxF Site of Protein Phosphatase 1 for HIV-1 Inhibition. ACS Infect Dis. 2020 12 11; 6(12):3190-3211. PMID: 33258581.
      Citations: 4     Fields:    Translation:HumansCells
    10. Wan S, Cao S, Wang X, Zhou Y, Yan W, Gu X, Wu TC, Pang X. Generation and preliminary characterization of vertebrate-specific replication-defective Zika virus. Virology. 2021 01 02; 552:73-82. PMID: 33075709.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    11. Sha W, Zhou Y, Ling ZQ, Xie G, Pang X, Wang P, Gu X. Antitumor properties of Salvianolic acid B against triple-negative and hormone receptor-positive breast cancer cells via ceramide-mediated apoptosis. Oncotarget. 2018 Nov 20; 9(91):36331-36343. PMID: 30555632.
      Citations: 16     Fields:    
    12. Zhu S, Liu Y, Wang PC, Gu X, Shan L. Recombinant Immunotoxin Therapy of Glioblastoma: Smart Design, Key Findings, and Specific Challenges. Biomed Res Int. 2017; 2017:7929286. PMID: 28752098.
      Citations: 6     Fields:    Translation:HumansAnimals
    13. Zhao Y, Ling Z, Hao Y, Pang X, Han X, Califano JA, Shan L, Gu X. MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma. Oncotarget. 2017 Apr 11; 8(15):25005-25020. PMID: 28212569.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    14. Zhu A, Guan X, Gu X, Xie G. Probe-free allele-specific copy number detection and analysis of tumors. Anal Biochem. 2016 Mar 15; 497:95-102. PMID: 26743720.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    15. Hauser B, Zhao Y, Pang X, Ling Z, Myers E, Wang P, Califano J, Gu X. Functions of MiRNA-128 on the regulation of head and neck squamous cell carcinoma growth and apoptosis. PLoS One. 2015; 10(3):e0116321. PMID: 25764126.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    16. Meng J, Liu Y, Gao S, Lin S, Gu X, Pomper MG, Wang PC, Shan L. A bivalent recombinant immunotoxin with high potency against tumors with EGFR and EGFRvIII expression. Cancer Biol Ther. 2015; 16(12):1764-74. PMID: 26467217.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    17. Pang X, Guo Y, Zhou Y, Fu W, Gu X. Highly efficient production of a dengue pseudoinfectious virus. Vaccine. 2014 Jun 24; 32(30):3854-60. PMID: 24797700.
      Citations: 4     Fields:    Translation:AnimalsCells
    18. Zhou Y, Sridhar R, Shan L, Sha W, Gu X, Sukumar S. Loperamide, an FDA-approved antidiarrhea drug, effectively reverses the resistance of multidrug resistant MCF-7/MDR1 human breast cancer cells to doxorubicin-induced cytotoxicity. Cancer Invest. 2012 Feb; 30(2):119-25. PMID: 22250587.
      Citations: 11     Fields:    Translation:HumansCells
    19. Hao Y, Gu X, Zhao Y, Greene S, Sha W, Smoot DT, Califano J, Wu TC, Pang X. Enforced expression of miR-101 inhibits prostate cancer cell growth by modulating the COX-2 pathway in vivo. Cancer Prev Res (Phila). 2011 Jul; 4(7):1073-83. PMID: 21430074.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    20. Hao Y, Zhao Y, Zhao X, He C, Pang X, Wu TC, Califano JA, Gu X. Improvement of prostate cancer detection by integrating the PSA test with miRNA expression profiling. Cancer Invest. 2011 May; 29(4):318-24. PMID: 21345070.
      Citations: 21     Fields:    Translation:HumansCells
    21. Zhao Y, Guo Y, Gu X. Salvianolic Acid B, a potential chemopreventive agent, for head and neck squamous cell cancer. J Oncol. 2011; 2011:534548. PMID: 21209716.
      Citations:    
    22. Zhao Y, Hao Y, Ji H, Fang Y, Guo Y, Sha W, Zhou Y, Pang X, Southerland WM, Califano JA, Gu X. Combination effects of salvianolic acid B with low-dose celecoxib on inhibition of head and neck squamous cell carcinoma growth in vitro and in vivo. Cancer Prev Res (Phila). 2010 Jun; 3(6):787-96. PMID: 20501859.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    23. Hao Y, Xie T, Korotcov A, Zhou Y, Pang X, Shan L, Ji H, Sridhar R, Wang P, Califano J, Gu X. Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivo via cyclooxygenase-2 and apoptotic pathways. Int J Cancer. 2009 May 01; 124(9):2200-9. PMID: 19123475.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    24. Gu X, Song X, Dong Y, Cai H, Walters E, Zhang R, Pang X, Xie T, Guo Y, Sridhar R, Califano JA. Vitamin E succinate induces ceramide-mediated apoptosis in head and neck squamous cell carcinoma in vitro and in vivo. Clin Cancer Res. 2008 Mar 15; 14(6):1840-8. PMID: 18347187.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    25. Shan L, Hao Y, Wang S, Korotcov A, Zhang R, Wang T, Califano J, Gu X, Sridhar R, Bhujwalla ZM, Wang PC. Visualizing head and neck tumors in vivo using near-infrared fluorescent transferrin conjugate. Mol Imaging. 2008 Jan-Feb; 7(1):42-9. PMID: 18384723.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    26. Zhou Y, Gu X, Ashayeri E, Zhang R, Sridhar R. Nicotine decreases the cytotoxicity of doxorubicin towards MCF-7 and KB-3.1 human cancer cells in culture. J Natl Med Assoc. 2007 Apr; 99(4):319-27. PMID: 17444420.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    27. Gu X, Schwartz JL, Pang X, Zhou Y, Sirois DA, Sridhar R. Cytotoxicity of liposomal alpha-tocopheryl succinate towards hamster cheek pouch carcinoma (HCPC-1) cells in culture. Cancer Lett. 2006 Aug 08; 239(2):281-91. PMID: 16271438.
      Citations:    Fields:    Translation:AnimalsCells
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