TNF-Related Apoptosis-Inducing Ligand

"TNF-Related Apoptosis-Inducing Ligand" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.

Descriptor ID	D053221
MeSH Number(s)	D12.644.276.374.750.625 D12.776.467.374.750.625 D23.529.374.750.625
Concept/Terms	TNF-Related Apoptosis-Inducing Ligand TNF-Related Apoptosis-Inducing Ligand Apoptosis-Inducing Ligand, TNF-Related TNF Related Apoptosis Inducing Ligand Apo-2 Ligand Apo 2 Ligand Tumor Necrosis Factor Ligand Superfamily Member 10 Apo-2L Protein Apo 2L Protein TNF Superfamily, Member 10 CD253 Antigen Antigen, CD253 TRAIL Protein

Below are MeSH descriptors whose meaning is more general than "TNF-Related Apoptosis-Inducing Ligand".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Tumor Necrosis Factors [D12.644.276.374.750]
TNF-Related Apoptosis-Inducing Ligand [D12.644.276.374.750.625]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Tumor Necrosis Factors [D12.776.467.374.750]
TNF-Related Apoptosis-Inducing Ligand [D12.776.467.374.750.625]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Tumor Necrosis Factors [D23.529.374.750]
TNF-Related Apoptosis-Inducing Ligand [D23.529.374.750.625]

Below are MeSH descriptors whose meaning is related to "TNF-Related Apoptosis-Inducing Ligand".

Below are MeSH descriptors whose meaning is more specific than "TNF-Related Apoptosis-Inducing Ligand".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "TNF-Related Apoptosis-Inducing Ligand" by people in this website by year, and whether "TNF-Related Apoptosis-Inducing Ligand" was a major or minor topic of these publications.

Bar chart showing 12 publications over 7 distinct years, with a maximum of 4 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	0	1	1
2006	0	1	1
2008	3	1	4
2010	3	0	3
2012	0	1	1
2014	1	0	1
2015	1	0	1

Below are the most recent publications written about "TNF-Related Apoptosis-Inducing Ligand" by people in Profiles.

Yoon JY, Cho HS, Lee JJ, Lee HJ, Jun SY, Lee JH, Song HH, Choi S, Saloura V, Park CG, Kim CH, Kim NS. Novel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells. Mol Carcinog. 2016 Apr; 55(4):387-96.

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Guicciardi ME, Werneburg NW, Bronk SF, Franke A, Yagita H, Thomas G, Gores GJ. Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. PLoS One. 2014; 9(3):e92124.

View in: PubMed
Song IS, Jun SY, Na HJ, Kim HT, Jung SY, Ha GH, Park YH, Long LZ, Yu DY, Kim JM, Kim JH, Ko JH, Kim CH, Kim NS. Inhibition of MKK7-JNK by the TOR signaling pathway regulator-like protein contributes to resistance of HCC cells to TRAIL-induced apoptosis. Gastroenterology. 2012 Nov; 143(5):1341-1351.

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Yu W, Tiwary R, Li J, Park SK, Jia L, Xiong A, Simmons-Menchaca M, Sanders BG, Kline K. a-TEA induces apoptosis of human breast cancer cells via activation of TRAIL/DR5 death receptor pathway. Mol Carcinog. 2010 Nov; 49(11):964-73.

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Tiwary R, Yu W, Li J, Park SK, Sanders BG, Kline K. Role of endoplasmic reticulum stress in alpha-TEA mediated TRAIL/DR5 death receptor dependent apoptosis. PLoS One. 2010 Jul 29; 5(7):e11865.

View in: PubMed
Brooks AD, Jacobsen KM, Li W, Shanker A, Sayers TJ. Bortezomib sensitizes human renal cell carcinomas to TRAIL apoptosis through increased activation of caspase-8 in the death-inducing signaling complex. Mol Cancer Res. 2010 May; 8(5):729-38.

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Kotliarova S, Pastorino S, Kovell LC, Kotliarov Y, Song H, Zhang W, Bailey R, Maric D, Zenklusen JC, Lee J, Fine HA. Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation. Cancer Res. 2008 Aug 15; 68(16):6643-51.

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Ndebele K, Gona P, Jin TG, Benhaga N, Chalah A, Degli-Esposti M, Khosravi-Far R. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3. Apoptosis. 2008 Jul; 13(7):845-56.

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Wang X, Chen W, Zeng W, Bai L, Tesfaigzi Y, Belinsky SA, Lin Y. Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells. Mol Cancer Ther. 2008 May; 7(5):1156-63.

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Shanker A, Brooks AD, Tristan CA, Wine JW, Elliott PJ, Yagita H, Takeda K, Smyth MJ, Murphy WJ, Sayers TJ. Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody. J Natl Cancer Inst. 2008 May 07; 100(9):649-62.

View in: PubMed

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