Protein Stability

"Protein Stability" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The ability of a protein to retain its structural conformation or its activity when subjected to physical or chemical manipulations.

Descriptor ID	D055550
MeSH Number(s)	G02.111.700
Concept/Terms	Protein Stability Protein Stability Protein Stabilities Stabilities, Protein Stability, Protein

Below are MeSH descriptors whose meaning is more general than "Protein Stability".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Protein Stability [G02.111.700]

Below are MeSH descriptors whose meaning is related to "Protein Stability".

Below are MeSH descriptors whose meaning is more specific than "Protein Stability".

Protein Stability
Enzyme Stability

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Stability" by people in this website by year, and whether "Protein Stability" was a major or minor topic of these publications.

Bar chart showing 42 publications over 17 distinct years, with a maximum of 8 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	0	1	1
2010	0	3	3
2011	1	2	3
2012	0	2	2
2013	0	8	8
2014	0	1	1
2015	0	5	5
2016	0	3	3
2017	0	1	1
2018	0	1	1
2019	0	2	2
2020	0	3	3
2021	0	4	4
2022	0	1	1
2024	1	1	2
2025	0	1	1
2026	0	1	1

Below are the most recent publications written about "Protein Stability" by people in Profiles.

Nakayama Y, Kitaura A, Abdali SA, Nguyen TD, Yoshioka J. Mutations in the Txnip PPXY motifs protect against myocardial infarction despite enhanced protein stability. Am J Physiol Heart Circ Physiol. 2026 Jun 01; 330(6):H1732-H1748.

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Anthony M, Xie Y, O'Neil JN, Teng S. Structural Analysis of Missense Mutations on the Stability of APOE3 and APOE4. Genes (Basel). 2025 Dec 16; 16(12).

View in: PubMed
Islam SM, Hasan MM, Alam J, Dey A, Molineaux D. In Silico Screening, Molecular Dynamics Simulation and Binding Free Energy Identify Single-Point Mutations That Destabilize p53 and Reduce Binding to DNA. Proteins. 2025 Feb; 93(2):498-514.

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Mahase V, Sobitan A, Yao Q, Shi X, Qin H, Kidane D, Tang Q, Teng S. Impact of Missense Mutations on Spike Protein Stability and Binding Affinity in the Omicron Variant. Viruses. 2024 07 17; 16(7).

View in: PubMed
Sobitan A, Edwards W, Jalal MS, Kolawole A, Ullah H, Duttaroy A, Li J, Teng S. Prediction of the Effects of Missense Mutations on Human Myeloperoxidase Protein Stability Using In Silico Saturation Mutagenesis. Genes (Basel). 2022 08 08; 13(8).

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Tanji T, Cohen E, Shen D, Zhang C, Yu F, Coleman AL, Zheng JJ. Age at Glaucoma Diagnosis in Germline Myocilin Mutation Patients: Associations with Polymorphisms in Protein Stabilities. Genes (Basel). 2021 11 16; 12(11).

View in: PubMed
Leysen S, Burnley RJ, Rodriguez E, Milroy LG, Soini L, Adamski CJ, Nitschke L, Davis R, Obsil T, Brunsveld L, Crabbe T, Zoghbi HY, Ottmann C, Davis JM. A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1. J Mol Biol. 2021 09 17; 433(19):167174.

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Cao H, Duncan O, Islam S, Zhang J, Ma W, Millar AH. Increased Wheat Protein Content via Introgression of an HMW Glutenin Selectively Reshapes the Grain Proteome. Mol Cell Proteomics. 2021; 20:100097.

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Walters TS, McIntosh DJ, Ingram SM, Tillery L, Motley ED, Arinze IJ, Misra S. SUMO-Modification of Human Nrf2 at K110 and K533 Regulates Its Nucleocytoplasmic Localization, Stability and Transcriptional Activity. Cell Physiol Biochem. 2021 Mar 27; 55(2):141-159.

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Arns T, Antunes DA, Abella JR, Rigo MM, Kavraki LE, Giuliatti S, Donadi EA. Structural Modeling and Molecular Dynamics of the Immune Checkpoint Molecule HLA-G. Front Immunol. 2020; 11:575076.

View in: PubMed

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