Ligands

"Ligands" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)

Descriptor ID	D008024
MeSH Number(s)	D27.720.470.480
Concept/Terms	Ligands Ligands

Below are MeSH descriptors whose meaning is more general than "Ligands".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Specialty Uses of Chemicals [D27.720]
Laboratory Chemicals [D27.720.470]
Ligands [D27.720.470.480]

Below are MeSH descriptors whose meaning is related to "Ligands".

Below are MeSH descriptors whose meaning is more specific than "Ligands".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ligands" by people in this website by year, and whether "Ligands" was a major or minor topic of these publications.

Bar chart showing 288 publications over 29 distinct years, with a maximum of 20 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	0	1	1
1998	0	2	2
1999	0	3	3
2000	0	6	6
2001	0	7	7
2002	0	13	13
2003	0	17	17
2004	0	15	15
2005	1	19	20
2006	0	10	10
2007	0	13	13
2008	0	15	15
2009	0	13	13
2010	1	8	9
2011	1	10	11
2012	2	9	11
2013	0	14	14
2014	0	15	15
2015	2	9	11
2016	0	12	12
2017	0	12	12
2018	1	9	10
2019	0	8	8
2020	0	12	12
2021	0	8	8
2022	0	11	11
2023	0	7	7
2024	0	1	1

Below are the most recent publications written about "Ligands" by people in Profiles.

Delaitre C, Boisbrun M, Acherar S, Dias A, Kleinclauss A, Achard M, Colin M, Nguyen TM, Humbert N, Chmeis K, Martinez KL, Gilles N, Robin P, Lecat S, Dupuis F. Synthesis and Pharmacological Characterization of Fluorescent Ligands Targeting the Angiotensin II Receptors Derived from Agonists, ?-Arrestin-Biased Agonists, and Antagonists. J Med Chem. 2024 Nov 28; 67(22):20275-20297.

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Dorogan M, Namballa HK, Harding WW. Natural Product-Inspired Dopamine Receptor Ligands. J Med Chem. 2024 Aug 08; 67(15):12463-12484.

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Wang B, Kobeissy F, Golpich M, Cai G, Li X, Abedi R, Haskins W, Tan W, Benner SA, Wang KKW. Aptamer Technologies in Neuroscience, Neuro-Diagnostics and Neuro-Medicine Development. Molecules. 2024 Mar 02; 29(5).

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Wu K, Karapetyan E, Schloss J, Vadgama J, Wu Y. Advancements in small molecule drug design: A structural perspective. Drug Discov Today. 2023 10; 28(10):103730.

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Namballa HK, Dorogan M, Gudipally AR, Okafor S, Gadhiya S, Harding WW. Discovery of Selective Dopamine Receptor Ligands Derived from (-)-Stepholidine via C-3 Alkoxylation and C-3/C-9 Dialkoxylation. J Med Chem. 2023 07 27; 66(14):10060-10079.

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Deng S, Jin P, Liu S, He Y, Sherchan P, Zhang JH, Gong Y, Tang J. Recruitment of regulatory T cells with rCCL17 promotes M2 microglia/macrophage polarization through TGF?/TGF?R/Smad2/3 pathway in a mouse model of intracerebral hemorrhage. Exp Neurol. 2023 09; 367:114451.

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Samanta PN, Majumdar D, Leszczynski J. Elucidating Atomistic Insight into the Dynamical Responses of the SARS-CoV-2 Main Protease for the Binding of Remdesivir Analogues: Leveraging Molecular Mechanics To Decode the Inhibition Mechanism. J Chem Inf Model. 2023 06 12; 63(11):3404-3422.

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Thapa R, Flores R, Cheng KH, Mochona B, Sikazwe D. Design and Synthesis of New Acyl Urea Analogs as Potential s1R Ligands. Molecules. 2023 Mar 02; 28(5).

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Phipps MD, Cingoranelli S, Bhupathiraju NVSDK, Younes A, Cao M, Sanders VA, Neary MC, Devany MH, Cutler CS, Lopez GE, Saini S, Parker CC, Fernandez SR, Lewis JS, Lapi SE, Francesconi LC, Deri MA. Sc-HOPO: A Potential Construct for Use in Radioscandium-Based Radiopharmaceuticals. Inorg Chem. 2023 Dec 18; 62(50):20567-20581.

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Cai T, Xie L, Zhang S, Chen M, He D, Badkul A, Liu Y, Namballa HK, Dorogan M, Harding WW, Mura C, Bourne PE, Xie L. End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins. PLoS Comput Biol. 2023 01; 19(1):e1010851.

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