Small Molecule Libraries

"Small Molecule Libraries" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.

Descriptor ID	D054852
MeSH Number(s)	D27.720.470.765
Concept/Terms	Small Molecule Libraries Small Molecule Libraries Libraries, Small Molecule Molecule Libraries, Small Molecular Libraries, Small Libraries, Small Molecular Small Molecular Libraries Chemical Libraries Libraries, Chemical

Below are MeSH descriptors whose meaning is more general than "Small Molecule Libraries".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Specialty Uses of Chemicals [D27.720]
Laboratory Chemicals [D27.720.470]
Small Molecule Libraries [D27.720.470.765]

Below are MeSH descriptors whose meaning is related to "Small Molecule Libraries".

Below are MeSH descriptors whose meaning is more specific than "Small Molecule Libraries".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Small Molecule Libraries" by people in this website by year, and whether "Small Molecule Libraries" was a major or minor topic of these publications.

Bar chart showing 35 publications over 14 distinct years, with a maximum of 5 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	1	0	1
2009	0	1	1
2010	0	2	2
2011	1	1	2
2012	4	1	5
2013	0	3	3
2014	0	1	1
2015	2	0	2
2016	3	1	4
2017	2	2	4
2018	2	1	3
2019	2	0	2
2020	3	0	3
2021	1	1	2

Below are the most recent publications written about "Small Molecule Libraries" by people in Profiles.

Wu K, Kwon SH, Zhou X, Fuller C, Wang X, Vadgama J, Wu Y. Overcoming Challenges in Small-Molecule Drug Bioavailability: A Review of Key Factors and Approaches. Int J Mol Sci. 2024 Dec 06; 25(23).

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Lamson DR, Tarpley M, Addo K, Ji X, Abu Rabe D, Ehe B, Hughes M, Smith GR, Daye LR, Musso DL, Zheng W, Williams KP. Identification of small molecule antagonists of sonic hedgehog/heparin binding with activity in hedgehog functional assays. Biochim Biophys Acta Gen Subj. 2024 Nov; 1868(11):130692.

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Alanazi A, Ivanov A, Kumari N, Lin X, Wang S, Kovalskyy D, Nekhai S. Targeting Tat-TAR RNA Interaction for HIV-1 Inhibition. Viruses. 2021 10 06; 13(10).

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Napoleon JV, Singh S, Rana S, Bendjennat M, Kumar V, Kizhake S, Palermo NY, Ouellette MM, Huxford T, Natarajan A. Small molecule binding to inhibitor of nuclear factor kappa-B kinase subunit beta in an ATP non-competitive manner. Chem Commun (Camb). 2021 May 11; 57(38):4678-4681.

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Shao Y, Zhang QC. Targeting RNA structures in diseases with small molecules. Essays Biochem. 2020 12 07; 64(6):955-966.

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Karaboga H, Huang W, Srivastava S, Widmann S, Addanki S, Gamage KT, Mazhar Z, Ebalunode JO, Briggs JM, Gustafsson J?, Filgueira CS, Gilbertson SR, Lin CY. Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity. ACS Chem Biol. 2020 11 20; 15(11):2916-2928.

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Singh JK, Hutt DM, Tait B, Guy NC, Sivils JC, Ortiz NR, Payan AN, Komaragiri SK, Owens JJ, Culbertson D, Blair LJ, Dickey C, Kuo SY, Finley D, Dyson HJ, Cox MB, Chaudhary J, Gestwicki JE, Balch WE. Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone. Cell Chem Biol. 2020 03 19; 27(3):292-305.e6.

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Wojnarowicz PM, Lima E Silva R, Ohnaka M, Lee SB, Chin Y, Kulukian A, Chang SH, Desai B, Garcia Escolano M, Shah R, Garcia-Cao M, Xu S, Kadam R, Goldgur Y, Miller MA, Ouerfelli O, Yang G, Arakawa T, Albanese SK, Garland WA, Stoller G, Chaudhary J, Norton L, Soni RK, Philip J, Hendrickson RC, Iavarone A, Dannenberg AJ, Chodera JD, Pavletich N, Lasorella A, Campochiaro PA, Benezra R. A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 2019 10 01; 29(1):62-75.e7.

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Loyola AC, Zhang L, Shang R, Dutta P, Li J, Li WX. Identification of methotrexate as a heterochromatin-promoting drug. Sci Rep. 2019 08 12; 9(1):11673.

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Rodriguez F, Iniguez E, Pena Contreras G, Ahmed H, Costa TEMM, Skouta R, Maldonado RA. Development of Thiophene Compounds as Potent Chemotherapies for the Treatment of Cutaneous Leishmaniasis Caused by Leishmania major. Molecules. 2018 07 04; 23(7).

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