Small Molecule Libraries

"Small Molecule Libraries" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.

Descriptor ID	D054852
MeSH Number(s)	D27.720.470.765
Concept/Terms	Small Molecule Libraries Small Molecule Libraries Libraries, Small Molecule Molecule Libraries, Small Molecular Libraries, Small Libraries, Small Molecular Small Molecular Libraries Chemical Libraries Libraries, Chemical

Below are MeSH descriptors whose meaning is more general than "Small Molecule Libraries".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Specialty Uses of Chemicals [D27.720]
Laboratory Chemicals [D27.720.470]
Small Molecule Libraries [D27.720.470.765]

Below are MeSH descriptors whose meaning is related to "Small Molecule Libraries".

Below are MeSH descriptors whose meaning is more specific than "Small Molecule Libraries".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Small Molecule Libraries" by people in this website by year, and whether "Small Molecule Libraries" was a major or minor topic of these publications.

Bar chart showing 46 publications over 16 distinct years, with a maximum of 5 publications in 2012 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	1	0	1
2009	0	1	1
2010	0	2	2
2011	1	1	2
2012	4	1	5
2013	0	3	3
2014	1	2	3
2015	3	0	3
2016	3	1	4
2017	2	2	4
2018	2	1	3
2019	2	0	2
2020	3	0	3
2021	2	1	3
2024	3	2	5
2025	1	1	2

Below are the most recent publications written about "Small Molecule Libraries" by people in Profiles.

Salinas Y, Chauhan SC, Bandyopadhyay D. Small-Molecule Mitotic Inhibitors as Anticancer Agents: Discovery, Classification, Mechanisms of Action, and Clinical Trials. Int J Mol Sci. 2025 Apr 01; 26(7).

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Saeger S, West-Jeppson K, Liao Y-R, Campuzano A, Yu J-J, Lopez-Ribot J, Hung C-Y. Discovery of novel antifungal drugs via screening repurposing libraries against Coccidioides posadasii spherule initials. mBio. 2025 May 14; 16(5):e0020525.

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Kashyap VK, Sharma BP, Pandey D, Singh AK, Peasah-Darkwah G, Singh B, Roy KK, Yallapu MM, Chauhan SC. Small Molecule with Big Impact: Metarrestin Targets the Perinucleolar Compartment in Cancer Metastasis. Cells. 2024 12 12; 13(24).

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Wu K, Kwon SH, Zhou X, Fuller C, Wang X, Vadgama J, Wu Y. Overcoming Challenges in Small-Molecule Drug Bioavailability: A Review of Key Factors and Approaches. Int J Mol Sci. 2024 Dec 06; 25(23).

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Galeano D, Haltom J, Andolino C, Yousey A, Zaksas V, Das S, Baylin SB, Wallace DC, Slack FJ, Enguita FJ, Wurtele ES, Teegarden D, Meller R, Cifuentes D, Beheshti A. sChemNET: a deep learning framework for predicting small molecules targeting microRNA function. Nat Commun. 2024 10 23; 15(1):9149.

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Pandey D, Chauhan SC, Kashyap VK, Roy KK. Structural insights into small-molecule KRAS inhibitors for targeting KRAS mutant cancers. Eur J Med Chem. 2024 Nov 05; 277:116771.

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Lamson DR, Tarpley M, Addo K, Ji X, Abu Rabe D, Ehe B, Hughes M, Smith GR, Daye LR, Musso DL, Zheng W, Williams KP. Identification of small molecule antagonists of sonic hedgehog/heparin binding with activity in hedgehog functional assays. Biochim Biophys Acta Gen Subj. 2024 11; 1868(11):130692.

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Alanazi A, Ivanov A, Kumari N, Lin X, Wang S, Kovalskyy D, Nekhai S. Targeting Tat-TAR RNA Interaction for HIV-1 Inhibition. Viruses. 2021 10 06; 13(10).

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Kaur K, Enders P, Zhu Y, Bratton AF, Powell CR, Kashfi K, Matson JB. Amino acid-based H2S donors: N-thiocarboxyanhydrides that release H2S with innocuous byproducts. Chem Commun (Camb). 2021 Jun 03; 57(45):5522-5525.

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Napoleon JV, Singh S, Rana S, Bendjennat M, Kumar V, Kizhake S, Palermo NY, Ouellette MM, Huxford T, Natarajan A. Small molecule binding to inhibitor of nuclear factor kappa-B kinase subunit beta in an ATP non-competitive manner. Chem Commun (Camb). 2021 May 11; 57(38):4678-4681.

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