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Ke Wu, MD, PhD

Title
InstitutionCharles R. Drew University of Medicine and Science
Address1731 E 120th St
Los Angeles CA 90059
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wu K, Karapetyan E, Schloss J, Vadgama J, Wu Y. Advancements in small molecule drug design: A structural perspective. Drug Discov Today. 2023 10; 28(10):103730. PMID: 37536390.
      Citations: 3     Fields:    Translation:Cells
    2. Wu Y, Shum HCE, Wu K, Vadgama J. From Interaction to Intervention: How Mesenchymal Stem Cells Affect and Target Triple-Negative Breast Cancer. Biomedicines. 2023 Apr 15; 11(4). PMID: 37189800.
      Citations:    
    3. Hsu WT, Tseng YH, Jui HY, Kuo CC, Wu KK, Lee CM. 5-Methoxytryptophan attenuates postinfarct cardiac injury by controlling oxidative stress and immune activation. J Mol Cell Cardiol. 2021 09; 158:101-114. PMID: 34087195.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    4. Wu KK. Cytoguardin: A Tryptophan Metabolite against Cancer Growth and Metastasis. Int J Mol Sci. 2021 Apr 26; 22(9). PMID: 33925793.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    5. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-G?mez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, ?lvarez ?MC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Ant?n Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Ara?jo WL, Araya J, Arden C, Ar?valo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnaun?-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, ?valos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, B?nr?ti ?, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Baril? D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touz? N, Bellarosa C, Belleudi F, Bell? P?rez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Bur?n MI, Bustos V, B?ttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cair? M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cant? C, Cao B, Caraglia M, Caram?s B, Carchman EH, Cardenal-Mu?oz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmona-Gutierrez D, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382. PMID: 33634751.
      Citations: 963     Fields:    Translation:HumansAnimalsCells
    6. Wu JY, Huang TW, Hsieh YT, Wang YF, Yen CC, Lee GL, Yeh CC, Peng YJ, Kuo YY, Wen HT, Lin HC, Hsiao CW, Wu KK, Kung HJ, Hsu YJ, Kuo CC. Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor. Mol Cell. 2020 01 16; 77(2):213-227.e5. PMID: 31735641.
      Citations: 179     Fields:    Translation:HumansAnimalsCells
    7. Wu K, Yu X, Huang Z, Zhu D, Yi X, Wu YL, Hao Q, Kemp KT, Elshimali Y, Iyer R, Nguyen KT, Zheng S, Chen G, Chen QH, Wang G, Vadgama JV, Wu Y. Targeting of PP2Cd By a Small Molecule C23 Inhibits High Glucose-Induced Breast Cancer Progression In Vivo. Antioxid Redox Signal. 2019 06 10; 30(17):1983-1998. PMID: 29808718.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    8. Chen HL, Yuan CY, Cheng HH, Chang TC, Huang SK, Kuo CC, Wu KK. Restoration of hydroxyindole O-methyltransferase levels in human cancer cells induces a tryptophan-metabolic switch and attenuates cancer progression. J Biol Chem. 2018 07 13; 293(28):11131-11142. PMID: 29794137.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    9. Wu KL, Huang EY, Yeh WL, Hsiao CC, Kuo CM. Synergistic interaction between galectin-3 and carcinoembryonic antigen promotes colorectal cancer metastasis. Oncotarget. 2017 Sep 22; 8(37):61935-61943. PMID: 28977916.
      Citations: 7     Fields:    
    10. Wu Y, Yu X, Yi X, Wu K, Dwabe S, Atefi M, Elshimali Y, Kemp KT, Bhat K, Haro J, Sarkissyan M, Vadgama JV. Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x-SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis. Cancer Res. 2017 03 15; 77(6):1383-1394. PMID: 28115363.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    11. Wang LT, Ting CH, Yen ML, Liu KJ, Sytwu HK, Wu KK, Yen BL. Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials. J Biomed Sci. 2016 Nov 04; 23(1):76. PMID: 27809910.
      Citations: 161     Fields:    Translation:HumansCells
    12. Peng KY, Lee YW, Hsu PJ, Wang HH, Wang Y, Liou JY, Hsu SH, Wu KK, Yen BL. Human pluripotent stem cell (PSC)-derived mesenchymal stem cells (MSCs) show potent neurogenic capacity which is enhanced with cytoskeletal rearrangement. Oncotarget. 2016 Jul 12; 7(28):43949-43959. PMID: 27304057.
      Citations: 14     Fields:    Translation:HumansCells
    13. Cheng HH, Chu LY, Chiang LY, Chen HL, Kuo CC, Wu KK. Inhibition of cancer cell epithelial mesenchymal transition by normal fibroblasts via production of 5-methoxytryptophan. Oncotarget. 2016 May 24; 7(21):31243-56. PMID: 27145282.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    14. Hsu WT, Jui HY, Huang YH, Su MY, Wu YW, Tseng WY, Hsu MC, Chiang BL, Wu KK, Lee CM. CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction. Cell Transplant. 2015; 24(7):1313-28. PMID: 24823505.
      Citations: 13     Fields:    Translation:AnimalsCells
    15. Hsu WT, Lin CH, Chiang BL, Jui HY, Wu KK, Lee CM. Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-?+CD4+ regulatory T cells to control transplant arteriosclerosis. J Immunol. 2013 Mar 01; 190(5):2372-80. PMID: 23359497.
      Citations: 52     Fields:    Translation:AnimalsCells
    16. Chen BR, Cheng HH, Lin WC, Wang KH, Liou JY, Chen PF, Wu KK. Quiescent fibroblasts are more active in mounting robust inflammatory responses than proliferative fibroblasts. PLoS One. 2012; 7(11):e49232. PMID: 23155470.
      Citations: 12     Fields:    Translation:HumansCells
    17. Wu KL, Huang EY, Jhu EW, Huang YH, Su WH, Chuang PC, Yang KD. Overexpression of galectin-3 enhances migration of colon cancer cells related to activation of the K-Ras-Raf-Erk1/2 pathway. J Gastroenterol. 2013 Mar; 48(3):350-9. PMID: 23015305.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    18. Lee GL, Chang YW, Wu JY, Wu ML, Wu KK, Yet SF, Kuo CC. TLR 2 induces vascular smooth muscle cell migration through cAMP response element-binding protein-mediated interleukin-6 production. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2751-60. PMID: 22995520.
      Citations: 39     Fields:    Translation:AnimalsCells
    19. Cheng HH, Kuo CC, Yan JL, Chen HL, Lin WC, Wang KH, Tsai KK, Guv?n H, Flaberg E, Szekely L, Klein G, Wu KK. Control of cyclooxygenase-2 expression and tumorigenesis by endogenous 5-methoxytryptophan. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13231-6. PMID: 22851770.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    20. Chang TC, Liu CC, Hsing EW, Liang SM, Chi YH, Sung LY, Lin SP, Shen TL, Ko BS, Yen BL, Yet SF, Wu KK, Liou JY. 14-3-3s regulates ?-catenin-mediated mouse embryonic stem cell proliferation by sequestering GSK-3?. PLoS One. 2012; 7(6):e40193. PMID: 22768254.
      Citations: 17     Fields:    Translation:AnimalsCells
    21. Jui HY, Lin CH, Hsu WT, Liu YR, Hsu RB, Chiang BL, Tseng WY, Chen MF, Wu KK, Lee CM. Autologous mesenchymal stem cells prevent transplant arteriosclerosis by enhancing local expression of interleukin-10, interferon-?, and indoleamine 2,3-dioxygenase. Cell Transplant. 2012; 21(5):971-84. PMID: 22449499.
      Citations: 17     Fields:    Translation:AnimalsCells
    22. Lin CY, Peng CY, Huang TT, Wu ML, Lai YL, Peng DH, Chen PF, Chen HF, Yen BL, Wu KK, Yet SF. Exacerbation of oxidative stress-induced cell death and differentiation in induced pluripotent stem cells lacking heme oxygenase-1. Stem Cells Dev. 2012 Jul 01; 21(10):1675-87. PMID: 22034921.
      Citations: 20     Fields:    Translation:AnimalsCells
    23. Shen HC, Ding FX, Raghavan S, Deng Q, Luell S, Forrest MJ, Carballo-Jane E, Wilsie LC, Krsmanovic ML, Taggart AK, Wu KK, Wu TJ, Cheng K, Ren N, Cai TQ, Chen Q, Wang J, Wolff MS, Tong X, Holt TG, Waters MG, Hammond ML, Tata JR, Colletti SL. Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J Med Chem. 2010 Mar 25; 53(6):2666-70. PMID: 20184326.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    24. Wu JS, Lin TN, Wu KK. Rosiglitazone and PPAR-gamma overexpression protect mitochondrial membrane potential and prevent apoptosis by upregulating anti-apoptotic Bcl-2 family proteins. J Cell Physiol. 2009 Jul; 220(1):58-71. PMID: 19229877.
      Citations: 44     Fields:    Translation:AnimalsCells
    25. Aleksic N, Wang YW, Ahn C, Juneja HS, Folsom AR, Wu KK. Assessment of coronary heart disease risk by combined analysis of coagulation factors. Atherosclerosis. 2008 Jun; 198(2):294-300. PMID: 18342864.
      Citations: 3     Fields:    Translation:Humans
    26. Liou JY, Ghelani D, Yeh S, Wu KK. Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon. Cancer Res. 2007 Apr 01; 67(7):3185-91. PMID: 17409426.
      Citations: 45     Fields:    Translation:HumansCells
    27. Little TJ, Doran S, Meyer JH, Smout AJ, O'Donovan DG, Wu KL, Jones KL, Wishart J, Rayner CK, Horowitz M, Feinle-Bisset C. The release of GLP-1 and ghrelin, but not GIP and CCK, by glucose is dependent upon the length of small intestine exposed. Am J Physiol Endocrinol Metab. 2006 Sep; 291(3):E647-55. PMID: 16684852.
      Citations: 37     Fields:    Translation:HumansCTClinical Trials
    28. Deng WG, Tang ST, Tseng HP, Wu KK. Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding. Blood. 2006 Jul 15; 108(2):518-24. PMID: 16609073.
      Citations: 95     Fields:    Translation:AnimalsCells
    29. Wu KK. Novel mechanisms of aspirin pharmacologic actions: a model for studying herbal natural products. Thromb Res. 2005; 117(1-2):61-4; discussion 65-7. PMID: 16045971.
      Citations: 2     Fields:    Translation:HumansAnimals
    30. Liou JY, Aleksic N, Chen SF, Han TJ, Shyue SK, Wu KK. Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance. Exp Cell Res. 2005 May 15; 306(1):75-84. PMID: 15878334.
      Citations: 23     Fields:    Translation:HumansCells
    31. Cieslik KA, Zhu Y, Shtivelband M, Wu KK. Inhibition of p90 ribosomal S6 kinase-mediated CCAAT/enhancer-binding protein beta activation and cyclooxygenase-2 expression by salicylate. J Biol Chem. 2005 May 06; 280(18):18411-7. PMID: 15738002.
      Citations: 6     Fields:    Translation:HumansCells
    32. Deng WG, Wu KK. Regulation of inducible nitric oxide synthase expression by p300 and p50 acetylation. J Immunol. 2003 Dec 15; 171(12):6581-8. PMID: 14662860.
      Citations: 29     Fields:    Translation:AnimalsCells
    33. Chen PF, Wu KK. Structural elements contribute to the calcium/calmodulin dependence on enzyme activation in human endothelial nitric-oxide synthase. J Biol Chem. 2003 Dec 26; 278(52):52392-400. PMID: 14561757.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    34. Wu KK. Control of COX-2 and iNOS gene expressions by aspirin and salicylate. Thromb Res. 2003 Jun 15; 110(5-6):273-6. PMID: 14592547.
      Citations: 9     Fields:    Translation:HumansAnimals
    35. Wu KK, Aleksic N, Ballantyne CM, Ahn C, Juneja H, Boerwinkle E. Interaction between soluble thrombomodulin and intercellular adhesion molecule-1 in predicting risk of coronary heart disease. Circulation. 2003 Apr 08; 107(13):1729-32. PMID: 12668515.
      Citations: 18     Fields:    Translation:Humans
    36. Chen PF, Berka V, Wu KK. Differential effects of mutations in human endothelial nitric oxide synthase at residues Tyr-357 and Arg-365 on L-arginine hydroxylation and GN-hydroxy-L-arginine oxidation. Arch Biochem Biophys. 2003 Mar 01; 411(1):83-92. PMID: 12590926.
      Citations: 2     Fields:    Translation:HumansCells
    37. Deng WG, Zhu Y, Wu KK. Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation. J Biol Chem. 2003 Feb 14; 278(7):4770-7. PMID: 12471036.
      Citations: 56     Fields:    Translation:HumansCells
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