Tryptophan

"Tryptophan" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.

Descriptor ID	D014364
MeSH Number(s)	D12.125.072.050.850 D12.125.142.875
Concept/Terms	Tryptophan Tryptophan L-Tryptophan L Tryptophan Levotryptophan Ardeydorm Ardeydorm Ardeytropin L-Tryptophan-ratiopharm L-Tryptophan-ratiopharm L Tryptophan ratiopharm ratio-Tryptophan ratio Tryptophan Tryptophan Metabolism Alterations Tryptophan Metabolism Alterations PMS-Tryptophan PMS-Tryptophan PMS Tryptophan Trofan Trofan Tryptacin Tryptacin Tryptan Tryptan Optimax Optimax Lyphan Lyphan Naturruhe

Below are MeSH descriptors whose meaning is more general than "Tryptophan".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Amino Acids [D12.125]
Amino Acids, Cyclic [D12.125.072]
Amino Acids, Aromatic [D12.125.072.050]
Tryptophan [D12.125.072.050.850]
Amino Acids, Essential [D12.125.142]
Tryptophan [D12.125.142.875]

Below are MeSH descriptors whose meaning is related to "Tryptophan".

Below are MeSH descriptors whose meaning is more specific than "Tryptophan".

Tryptophan
5-Hydroxytryptophan

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tryptophan" by people in this website by year, and whether "Tryptophan" was a major or minor topic of these publications.

Bar chart showing 65 publications over 23 distinct years, with a maximum of 9 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1996	0	1	1
1997	1	0	1
2000	1	0	1
2001	1	1	2
2003	5	1	6
2004	5	4	9
2005	1	4	5
2007	2	2	4
2008	0	1	1
2009	1	0	1
2010	2	1	3
2011	3	2	5
2012	1	2	3
2013	1	2	3
2014	3	2	5
2016	1	2	3
2017	1	0	1
2018	1	0	1
2019	0	2	2
2021	3	0	3
2022	0	3	3
2023	0	1	1

Below are the most recent publications written about "Tryptophan" by people in Profiles.

Chuang TD, Ton N, Rysling S, Quintanilla D, Boos D, Khorram O. Therapeutic effects of in?vivo administration of an inhibitor of tryptophan 2,3-dioxygenase (680c91) for the treatment of fibroids: a preclinical study. Fertil Steril. 2024 Apr; 121(4):669-678.

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Wiere S, Sugai C, Espiritu MJ, Aurelio VP, Reyes CD, Yuzon N, Whittal RM, Tytgat J, Peigneur S, Bingham JP. Research into the Bioengineering of a Novel a-Conotoxin from the Milked Venom of Conus obscurus. Int J Mol Sci. 2022 Oct 11; 23(20).

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Carrico AW, Cherenack EM, Rubin LH, McIntosh R, Ghanooni D, Chavez JV, Klatt NR, Paul RH. Through the Looking-Glass: Psychoneuroimmunology and the Microbiome-Gut-Brain Axis in the Modern Antiretroviral Therapy Era. Psychosom Med. 2022 10 01; 84(8):984-994.

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Chuang TD, Quintanilla D, Boos D, Khorram O. Further characterization of tryptophan metabolism and its dysregulation in fibroids. F S Sci. 2022 11; 3(4):392-400.

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Chuang TD, Quintanilla D, Boos D, Khorram O. Tryptophan catabolism is dysregulated in leiomyomas. Fertil Steril. 2021 10; 116(4):1160-1171.

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Hsu WT, Tseng YH, Jui HY, Kuo CC, Wu KK, Lee CM. 5-Methoxytryptophan attenuates postinfarct cardiac injury by controlling oxidative stress and immune activation. J Mol Cell Cardiol. 2021 09; 158:101-114.

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Wu KK. Cytoguardin: A Tryptophan Metabolite against Cancer Growth and Metastasis. Int J Mol Sci. 2021 Apr 26; 22(9).

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Zhou Y, Liu CH, Wu B, Yu X, Cheng G, Zhu K, Wang K, Zhang C, Zhao M, Zong R, Zhang L, Shi L, Alfano RR. Optical biopsy identification and grading of gliomas using label-free visible resonance Raman spectroscopy. J Biomed Opt. 2019 09; 24(9):1-12.

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Vantaku V, Putluri V, Bader DA, Maity S, Ma J, Arnold JM, Rajapakshe K, Donepudi SR, von Rundstedt FC, Devarakonda V, Dubrulle J, Karanam B, McGuire SE, Stossi F, Jain AK, Coarfa C, Cao Q, Sikora AG, Villanueva H, Kavuri SM, Lotan Y, Sreekumar A, Putluri N. Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. Oncogene. 2020 10; 39(40):6265-6285.

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Chen HL, Yuan CY, Cheng HH, Chang TC, Huang SK, Kuo CC, Wu KK. Restoration of hydroxyindole O-methyltransferase levels in human cancer cells induces a tryptophan-metabolic switch and attenuates cancer progression. J Biol Chem. 2018 07 13; 293(28):11131-11142.

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