Thyroxine

"Thyroxine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.

Descriptor ID	D013974
MeSH Number(s)	D06.472.931.812 D12.125.072.050.767
Concept/Terms	Thyroxine Thyroxine T4 Thyroid Hormone Thyroid Hormone, T4 Thyroxin O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine L-3,5,3',5'-Tetraiodothyronine Levothyroxine L-Thyroxine L Thyroxine 3,5,3',5'-Tetraiodothyronine O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine L-Thyroxin Henning L-Thyroxin Henning L Thyroxin Henning LThyroxin Henning Levothyroxine Sodium Levothyroxine Sodium Sodium Levothyroxine Levoxine Levoxine Levoxyl Levoxyl Lévothyrox Lévothyrox L-Thyroxine Roche L-Thyroxine Roche L Thyroxine Roche Levo-T Levo-T Levo T LevoT Levothroid Levothroid Novothyral Novothyral Berlthyrox Berlthyrox Dexnon Dexnon Novothyrox Novothyrox Oroxine Oroxine Synthroid Synthroid Synthrox Synthrox Thyrax Thyrax Tiroidine Tiroidine Tiroxina Leo Tiroxina Leo Leo, Tiroxina Unithroid Unithroid Eferox Eferox Eltroxin Eltroxin Thevier Eltroxine Eltroxine Euthyrox Euthyrox Eutirox L-Thyrox L-Thyrox L Thyrox L-Thyroxin beta L-Thyroxin beta L Thyroxin beta LThyroxin beta Levothyroid Levothyroid Levothyroxin Deladande Levothyroxin Deladande Deladande, Levothyroxin Levothyroxin Delalande Delalande, Levothyroxin

Below are MeSH descriptors whose meaning is more general than "Thyroxine".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Thyroid Hormones [D06.472.931]
Thyroxine [D06.472.931.812]
Amino Acids, Peptides, and Proteins [D12]
Amino Acids [D12.125]
Amino Acids, Cyclic [D12.125.072]
Amino Acids, Aromatic [D12.125.072.050]
Thyroxine [D12.125.072.050.767]

Below are MeSH descriptors whose meaning is related to "Thyroxine".

Below are MeSH descriptors whose meaning is more specific than "Thyroxine".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Thyroxine" by people in this website by year, and whether "Thyroxine" was a major or minor topic of these publications.

Bar chart showing 15 publications over 12 distinct years, with a maximum of 2 publications in 2004 and 2016 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	1	0	1
1999	0	1	1
2001	0	1	1
2004	0	2	2
2005	1	0	1
2007	0	1	1
2010	0	1	1
2015	0	1	1
2016	2	0	2
2017	0	2	2
2021	1	0	1

Below are the most recent publications written about "Thyroxine" by people in Profiles.

Seale LA, Gilman CL, Zavacki AM, Larsen PR, Inokuchi M, Breves JP, Seale AP. Regulation of thyroid hormones and branchial iodothyronine deiodinases during freshwater acclimation in tilapia. Mol Cell Endocrinol. 2021 12 01; 538:111450.

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Taylor PN, Sayers A, Okosieme O, Das G, Draman MS, Tabasum A, Abusahmin H, Rahman M, Stevenson K, Groom A, Northstone K, Woltersdorf W, Taylor A, Ring S, Lazarus JH, Gregory JW, Rees A, Timpson N, Dayan CM. Maturation in Serum Thyroid Function Parameters Over Childhood and Puberty: Results of a Longitudinal Study. J Clin Endocrinol Metab. 2017 07 01; 102(7):2508-2515.

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Kar S, Sep?lveda MS, Roy K, Leszczynski J. Endocrine-disrupting activity of per- and polyfluoroalkyl substances: Exploring combined approaches of ligand and structure based modeling. Chemosphere. 2017 Oct; 184:514-523.

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Gardell AM, von Hippel FA, Adams EM, Dillon DM, Petersen AM, Postlethwait JH, Cresko WA, Buck CL. Exogenous iodide ameliorates perchlorate-induced thyroid phenotypes in threespine stickleback. Gen Comp Endocrinol. 2017 03 01; 243:60-69.

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Maher SK, Wojnarowicz P, Ichu TA, Veldhoen N, Lu L, Lesperance M, Propper CR, Helbing CC. Rethinking the biological relationships of the thyroid hormones, l-thyroxine and 3,5,3'-triiodothyronine. Comp Biochem Physiol Part D Genomics Proteomics. 2016 06; 18:44-53.

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Taylor PN, Richmond R, Davies N, Sayers A, Stevenson K, Woltersdorf W, Taylor A, Groom A, Northstone K, Ring S, Okosieme O, Rees A, Nitsch D, Williams GR, Smith GD, Gregory JW, Timpson NJ, Tobias JH, Dayan CM. Paradoxical Relationship Between Body Mass Index and Thyroid Hormone Levels: A Study Using Mendelian Randomization. J Clin Endocrinol Metab. 2016 Feb; 101(2):730-8.

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Downing S, Halpern L, Carswell J, Brown RS. Severe maternal hypothyroidism corrected prior to the third trimester is associated with normal cognitive outcome in the offspring. Thyroid. 2012 Jun; 22(6):625-30.

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Miller VM, Lawrence DA, Coccaro GA, Mondal TK, Andrews K, Dreiem A, Seegal RF. Sex effects of interleukin-6 deficiency on neuroinflammation in aged C57Bl/6 mice. Brain Res. 2010 Mar 08; 1318:11-22.

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de Jong FJ, Masaki K, Chen H, Remaley AT, Breteler MM, Petrovitch H, White LR, Launer LJ. Thyroid function, the risk of dementia and neuropathologic changes: the Honolulu-Asia aging study. Neurobiol Aging. 2009 Apr; 30(4):600-6.

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Bigbee AJ, Grindeland RE, Roy RR, Zhong H, Gosselink KL, Arnaud S, Edgerton VR. Basal and evoked levels of bioassayable growth hormone are altered by hindlimb unloading. J Appl Physiol (1985). 2006 Mar; 100(3):1037-42.

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