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Lucia Seale

Title
Faculty RankAssistant Researcher
InstitutionUniversity of Hawaii at Manoa
DepartmentCell and Molecular Biology
AddressPacific Biosciences Research Center
University of Hawaii at Manoa
1993 East-West Road
Honolulu HI 96822
ORCID ORCID Icon0000-0002-0686-7516 Additional info
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    R01DK128390     (SEALE, LUCIA ANDREIA)Apr 22, 2021 - Mar 31, 2026
    NIH
    Selenium metabolism in cold-induced adaptive thermogenesis
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Breves JP, Hu MW, Inokuchi M, Seale LA, Seale AP. Prolactin, cortisol, and extracellular osmolality regulate cftr, ostf1, and sgk1 in tilapia ionocytes. Front Endocrinol (Lausanne). 2026; 17:1802254. PMID: 42100191.
      Citations:    Fields:    Translation:Animals
    2. Abd El-Aziz TM, Al-Sabi A, Seale LA, Soares AG. Current understanding of ENaC regulation by P2Y2/PLC/PI(4,5)P2 pathway. Purinergic Signal. 2026 Jan 07; 22(1):2. PMID: 41498836.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Shimada BK, Ogawa-Wong AN, Soares AG, Hallam KA, Santiago PJD, Saelua K, Nakahara-Akita KK, Torres DJ, Brockman JD, Kurokawa S, Ewell KL, Bellinger MT, Toh P, Lagatta Pamplona Remedios G, Alfulaij N, Swanson SM, Seyedali A, Zavacki AM, Berry MJ, Seale LA. Global loss of selenocysteine lyase in mice drives lipid accumulation in brown adipocytes. Am J Physiol Endocrinol Metab. 2026 02 01; 330(2):E000. PMID: 41452587.
      Citations:    Fields:    Translation:AnimalsCells
    4. Santiago PJD, Shimada BK, Alfulaij N, Hallam KA, Soares AG, Young V, Swanson SM, Remedios GL, Toh P, Seale LA. Targeted Disruption of Selenocysteine Lyase in Brown Adipocytes Controls Glutathione Peroxidase 1 and 4 Expression in Males. Biol Trace Elem Res. 2026 May; 204(5):3437-3450. PMID: 41366172.
      Citations:    Fields:    Translation:AnimalsCells
    5. Shimada BK, Watanabe M, Apo Takayama NK, Soares AG, Hallam KA, Rivers OS, Ewell K, Santiago PJD, Swanson SM, Toh P, Alfulaij N, Berry MJ, Seale LA. Cardiac redox imbalance upon disruption of selenocysteine decomposition in mice. Am J Physiol Heart Circ Physiol. 2025 Dec 01; 329(6):H1480-H1496. PMID: 41134664.
      Citations:    Fields:    Translation:AnimalsCells
    6. Swirski MI, Tierney JAS, Alb? MM, Andreev DE, Aspden JL, Atkins JF, Bassani-Sternberg M, Berry MJ, Biffo S, Boris-Lawrie K, Borodovsky M, Brierley I, Brook M, Brunet MA, Bujnicki JM, Caliskan N, Calviello L, Carvunis AR, Cate JHD, Cenik C, Chang KY, Chen Y, Chothani S, Choudhary JS, Clark PL, Clauwaert J, Cooley L, Dassi E, Dean K, Diaz JJ, Dieterich C, Dikstein R, Dinman JD, Dmitriev SE, Dontsova OA, Dunham CM, Eswarappa SM, Farabaugh PJ, Faridi P, Fierro-Monti I, Firth AE, Gatfield D, Gebauer F, Gelfand MS, Gray NK, Green R, Hill CH, Hou YM, H?bner N, Ignatova Z, Ivanov P, Iwasaki S, Johnson R, Jomaa A, Jovanovic M, Jungreis I, Kellis M, Kieft JS, Kochetov AV, Koonin EV, Korostelev AA, Kufel J, Kulakovskiy IV, Kurian L, Lafontaine DLJ, Larsson O, Loughran G, Luke? J, Mariotti M, Martens-Uzunova ES, Martinez TF, Matsumoto A, McManus J, Medenbach J, Melnikov SV, Menschaert G, Merchante C, Mikl M, Miller WA, M?hlemann O, Namy O, Nedialkova DD, Nosek J, Orchard S, Ozretic P, Pertea M, Pervouchine DD, Rom?o L, Ron D, Roucou X, Rubtsova MP, Ruiz-Orera J, Saghatelian A, Salzberg SL, Seale LA, Seoighe C, Sergiev PV, Shah P, Shirokikh N, Slavoff SA, Sonenberg N, Stasevich TJ, Szczesny RJ, Tamm T, Tch?rzewski M, Topisirovic I, Tremblay ML, Tuller T, Ulitsky I, Val?ek LS, Van Damme P, Viero G, Vizcaino JA, Vogel C, Wallace EWJ, Weissman JS, Westhof E, Whiffin N, Wilson DN, Xie Z, Yewdell JW, Yordanova MM, Yu CH, Yurchenko V, Zagrovic B, Valen E, Baranov PV. Translon: a single term for translated regions. Nat Methods. 2025 Oct; 22(10):2002-2006. PMID: 40890551.
      Citations: 4     Fields:    
    7. Chen Z, Inague A, Kaushal K, Fazeli G, Schilling D, Xavier da Silva TN, Ferreira Dos Santos A, Cheytan T, Freitas FP, Yildiz U, Viviani LG, Lima RS, Pinz MP, Medeiros I, Iijima TS, Pires Alegria TG, Pereira da Silva R, Diniz LR, Weinzweig S, Klein-Seetharaman J, Trumpp A, Ma?as A, Hondal R, Bartenhagen C, Fischer M, Shimada BK, Seale LA, Chillon TS, Fabiano M, Schomburg L, Schweizer U, Netto LE, Meotti FC, Dick TP, Alborzinia H, Miyamoto S, Friedmann Angeli JP. PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance. Mol Cell. 2025 Sep 04; 85(17):3343-3344. PMID: 40816288.
      Citations: 1     Fields:    
    8. Lee KCY, Williams AL, Fujimoto A, Gerschenson M, Schuller C, Polgar N, Alfulaij N, Shimada BK, Seale LA, Shohet RV. PKM2 is a key regulator of cardiac lipid metabolism in mice. Mitochondrion. 2025 Nov; 85:102070. PMID: 40706825.
      Citations: 1     Fields:    Translation:AnimalsCells
    9. Abd El-Aziz TM, Mironova E, Stockand JD, Seale LA, Soares AG. Gi-DREADD activation decreases Epithelial Na+ channel activity in renal principal cells. Physiol Rep. 2025 Jun; 13(12):e70433. PMID: 40526015.
      Citations:    Fields:    Translation:AnimalsCells
    10. Seale LA, Yamanaka AB, Hammond K, Lim E, Wilkens LR, McFall P, Aflague TF, Coleman P, Fleming T, Shallcross L, Deenik J, Novotny R. Dietary Micronutrient Intake and the Prevalence of Metabolic Conditions among Children from the United States-Affiliated Pacific Region in the Children's Healthy Living Program. Curr Dev Nutr. 2025 Jan; 9(1):104531. PMID: 40905003.
      Citations:    
    11. Chen Z, Inague A, Kaushal K, Fazeli G, Schilling D, Xavier da Silva TN, Dos Santos AF, Cheytan T, Freitas FP, Yildiz U, Viviani LG, Lima RS, Pinz MP, Medeiros I, Iijima TS, Alegria TGP, Pereira da Silva R, Diniz LR, Weinzweig S, Klein-Seetharaman J, Trumpp A, Ma?as A, Hondal R, Bartenhagen C, Fischer M, Shimada BK, Seale LA, Chillon TS, Fabiano M, Schomburg L, Schweizer U, Netto LE, Meotti FC, Dick TP, Alborzinia H, Miyamoto S, Friedmann Angeli JP. PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance. Mol Cell. 2024 Dec 05; 84(23):4645-4659.e9. PMID: 39547224.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    12. Chen Z, Inague A, Kaushal K, Fazeli G, N Xavier da Silva T, Ferreira Dos Santos A, Cheytan T, Porto Freitas F, Yildiz U, Gasparello Viviani L, Santiago Lima R, Peglow Pinz M, Medeiros I, Geronimo Pires Alegria T, Pereira da Silva R, Regina Diniz L, Weinzweig S, Klein-Seetharaman J, Trumpp A, Manas A, Hondal R, Fischer M, Bartenhagen C, Shimada BK, Seale LA, Fabiano M, Schweizer U, Netto LE, Meotti FC, Alborzinia H, Miyamoto S, Friedmann Angeli JP. PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance. bioRxiv. 2024 Jun 06. PMID: 38895225.
      Citations:    
    13. Ralston NVC, Raymond LJ, Gilman CL, Soon R, Seale LA, Berry MJ. Maternal seafood consumption is associated with improved selenium status: Implications for child health. Neurotoxicology. 2024 03; 101:26-35. PMID: 38272071.
      Citations: 1     Fields:    Translation:HumansAnimals
    14. Toh P, Seale LA, Berry MJ, Torres DJ. Prolonged maternal exposure to glucocorticoids alters selenoprotein expression in the developing brain. Front Mol Neurosci. 2023; 16:1115993. PMID: 37033382.
      Citations:    
    15. An KJ, Hanato AN, Hui KW, Pitts MW, Seale LA, Nicholson JL, Toh P, Kim JK, Berry MJ, Torres DJ. Selenium Protects Mouse Hypothalamic Cells from Glucocorticoid-Induced Endoplasmic Reticulum Stress Vulnerability and Insulin Signaling Impairment. Antioxidants (Basel). 2023 Feb 20; 12(2). PMID: 36830084.
      Citations:    
    16. Shimada BK, Swanson S, Toh P, Seale LA. Metabolism of Selenium, Selenocysteine, and Selenoproteins in Ferroptosis in Solid Tumor Cancers. Biomolecules. 2022 10 28; 12(11). PMID: 36358931.
      Citations: 25     Fields:    Translation:Humans
    17. Shimada BK, Watanabe LM, Swanson S, Toh P, Seale LA. Selenium and selenoproteins in thermogenic adipocytes. Arch Biochem Biophys. 2022 11 30; 731:109445. PMID: 36265651.
      Citations: 10     Fields:    Translation:Cells
    18. Watanabe LM, Seale LA. Challenging Aspects to Precise Health Strategies in Native Hawaiian and Other Pacific Islanders Using Statins. Front Public Health. 2022; 10:799731. PMID: 35296045.
      Citations: 4     Fields:    Translation:Humans
    19. Cardoso BR, Cominetti C, Seale LA. Editorial: Selenium, Human Health and Chronic Disease. Front Nutr. 2021; 8:827759. PMID: 35118114.
      Citations:    
    20. Day K, Seale LA, Graham RM, Cardoso BR. Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease. Front Nutr. 2021; 8:744825. PMID: 34869521.
      Citations:    
    21. Torres DJ, Pitts MW, Seale LA, Hashimoto AC, An KJ, Hanato AN, Hui KW, Remigio SMA, Carlson BA, Hatfield DL, Berry MJ. Female Mice with Selenocysteine tRNA Deletion in Agrp Neurons Maintain Leptin Sensitivity and Resist Weight Gain While on a High-Fat Diet. Int J Mol Sci. 2021 Oct 12; 22(20). PMID: 34681674.
      Citations: 3     Fields:    Translation:AnimalsCells
    22. Shimada BK, Alfulaij N, Seale LA. The Impact of Selenium Deficiency on Cardiovascular Function. Int J Mol Sci. 2021 Oct 02; 22(19). PMID: 34639053.
      Citations: 65     Fields:    Translation:HumansAnimals
    23. Seale LA, Gilman CL, Zavacki AM, Larsen PR, Inokuchi M, Breves JP, Seale AP. Regulation of thyroid hormones and branchial iodothyronine deiodinases during freshwater acclimation in tilapia. Mol Cell Endocrinol. 2021 12 01; 538:111450. PMID: 34506867.
      Citations: 1     Fields:    Translation:Animals
    24. Watanabe LM, Navarro AM, Seale LA. Intersection between Obesity, Dietary Selenium, and Statin Therapy in Brazil. Nutrients. 2021 Jun 12; 13(6). PMID: 34204631.
      Citations: 9     Fields:    Translation:Humans
    25. Watanabe LM, Hashimoto AC, Torres DJ, Alfulaij N, Peres R, Sultana R, Maunakea AK, Berry MJ, Seale LA. Effect of statin treatment in obese selenium-supplemented mice lacking selenocysteine lyase. Mol Cell Endocrinol. 2021 08 01; 533:111335. PMID: 34052303.
      Citations: 4     Fields:    Translation:Animals
    26. Seale LA, Ogawa-Wong AN, Watanabe LM, Khadka VS, Menor M, Torres DJ, Carlson BA, Hatfield DL, Berry MJ. Adaptive Thermogenesis in a Mouse Model Lacking Selenoprotein Biosynthesis in Brown Adipocytes. Int J Mol Sci. 2021 Jan 09; 22(2). PMID: 33435397.
      Citations: 6     Fields:    Translation:AnimalsCells
    27. Seale LA, Torres DJ, Berry MJ, Pitts MW. A role for selenium-dependent GPX1 in SARS-CoV-2 virulence. Am J Clin Nutr. 2020 08 01; 112(2):447-448. PMID: 32592394.
      Citations: 39     Fields:    Translation:HumansCellsPHPublic Health
    28. Watanabe LM, Hashimoto AC, Torres DJ, Berry MJ, Seale LA. Effects of selenium supplementation on diet-induced obesity in mice with a disruption of the selenocysteine lyase gene. J Trace Elem Med Biol. 2020 Dec; 62:126596. PMID: 32683228.
      Citations: 9     Fields:    Translation:Animals
    29. Seale LA, Khadka VS, Menor M, Xie G, Watanabe LM, Sasuclark A, Guirguis K, Ha HY, Hashimoto AC, Peplowska K, Tiirikainen M, Jia W, Berry MJ, Deng Y. Combined Omics Reveals That Disruption of the Selenocysteine Lyase Gene Affects Amino Acid Pathways in Mice. Nutrients. 2019 Oct 26; 11(11). PMID: 31717805.
      Citations: 4     Fields:    Translation:AnimalsCells
    30. Seale LA. Selenocysteine ?-Lyase: Biochemistry, Regulation and Physiological Role of the Selenocysteine Decomposition Enzyme. Antioxidants (Basel). 2019 Sep 01; 8(9). PMID: 31480609.
      Citations:    
    31. Ha HY, Alfulaij N, Berry MJ, Seale LA. From Selenium Absorption to Selenoprotein Degradation. Biol Trace Elem Res. 2019 Nov; 192(1):26-37. PMID: 31222623.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    32. Seale LA, Ogawa-Wong AN, Berry MJ. SEXUAL DIMORPHISM IN SELENIUM METABOLISM AND SELENOPROTEINS. Free Radic Biol Med. 2018 11 01; 127:198-205. PMID: 29572096.
      Citations: 41     Fields:    Translation:HumansAnimals
    33. Seale LA, Ha HY, Hashimoto AC, Berry MJ. Relationship between selenoprotein P and selenocysteine lyase: Insights into selenium metabolism. Free Radic Biol Med. 2018 11 01; 127:182-189. PMID: 29567390.
      Citations: 24     Fields:    Translation:HumansAnimals
    34. Ogawa-Wong AN, Hashimoto AC, Ha H, Pitts MW, Seale LA, Berry MJ. Sexual Dimorphism in the Selenocysteine Lyase Knockout Mouse. Nutrients. 2018 Jan 31; 10(2). PMID: 29385050.
      Citations: 14     Fields:    Translation:Animals
    35. Ogawa-Wong AN, Berry MJ, Seale LA. Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk. Nutrients. 2016 Feb 06; 8(2):80. PMID: 26861388.
      Citations: 61     Fields:    Translation:Humans
    36. Seale LA, Gilman CL, Hashimoto AC, Ogawa-Wong AN, Berry MJ. Diet-induced obesity in the selenocysteine lyase knockout mouse. Antioxid Redox Signal. 2015 Oct 01; 23(10):761-74. PMID: 26192035.
      Citations: 28     Fields:    Translation:AnimalsCells
    37. Berry MJ, Astern J, Bellinger F, Brampton C, Cann R, Gerschenson M, Haymer D, James NG, Jameson DM, LeSaux O, Hoffmann PR, Nichols R, Pitts M, Seale L, Seifried S, Stokes AJ, Todorovic C. Medical school hotline: the research mission of the cell and molecular biology department and program at the john a. Burns school of medicine. Hawaii J Med Public Health. 2015 Apr; 74(4):150-3. PMID: 25954603.
      Citations:    Fields:    Translation:Humans
    38. Seale LA, Gilman CL, Moorman BP, Berry MJ, Grau EG, Seale AP. Effects of acclimation salinity on the expression of selenoproteins in the tilapia, Oreochromis mossambicus. J Trace Elem Med Biol. 2014 Jul; 28(3):284-92. PMID: 24854764.
      Citations: 5     Fields:    Translation:Animals
    39. Pitts MW, Reeves MA, Hashimoto AC, Ogawa A, Kremer P, Seale LA, Berry MJ. Deletion of selenoprotein M leads to obesity without cognitive deficits. J Biol Chem. 2013 Sep 06; 288(36):26121-26134. PMID: 23880772.
      Citations: 55     Fields:    Translation:Animals
    40. Seale LA, Hashimoto AC, Kurokawa S, Gilman CL, Seyedali A, Bellinger FP, Raman AV, Berry MJ. Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice. Mol Cell Biol. 2012 Oct; 32(20):4141-54. PMID: 22890841.
      Citations: 64     Fields:    Translation:Animals
    41. Bellinger FP, Raman AV, Rueli RH, Bellinger MT, Dewing AS, Seale LA, Andres MA, Uyehara-Lock JH, White LR, Ross GW, Berry MJ. Changes in selenoprotein P in substantia nigra and putamen in Parkinson's disease. J Parkinsons Dis. 2012; 2(2):115-26. PMID: 23268326.
      Citations: 29     Fields:    Translation:Humans
    42. Bellinger FP, Bellinger MT, Seale LA, Takemoto AS, Raman AV, Miki T, Manning-Bog AB, Berry MJ, White LR, Ross GW. Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain. Mol Neurodegener. 2011 Jan 21; 6(1):8. PMID: 21255396.
      Citations: 78     Fields:    
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