Receptors, Serotonin

"Receptors, Serotonin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.

Descriptor ID	D011985
MeSH Number(s)	D12.776.543.750.670.800 D12.776.543.750.695.800 D12.776.543.750.720.850
Concept/Terms	Receptors, Serotonin Receptors, Serotonin 5-Hydroxytryptamine Receptors 5 Hydroxytryptamine Receptors 5-HT Receptors 5 HT Receptors Receptors, 5-HT Receptors, 5 HT Receptors, 5-Hydroxytryptamine Receptors, 5 Hydroxytryptamine Serotonin Receptors Receptors, Tryptamine Receptors, Tryptamine Tryptamine Receptors

Below are MeSH descriptors whose meaning is more general than "Receptors, Serotonin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Biogenic Amine [D12.776.543.750.670]
Receptors, Serotonin [D12.776.543.750.670.800]
Receptors, G-Protein-Coupled [D12.776.543.750.695]
Receptors, Serotonin [D12.776.543.750.695.800]
Receptors, Neurotransmitter [D12.776.543.750.720]
Receptors, Serotonin [D12.776.543.750.720.850]

Below are MeSH descriptors whose meaning is related to "Receptors, Serotonin".

Below are MeSH descriptors whose meaning is more specific than "Receptors, Serotonin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, Serotonin" by people in this website by year, and whether "Receptors, Serotonin" was a major or minor topic of these publications.

Bar chart showing 18 publications over 13 distinct years, with a maximum of 2 publications in 2001 and 2002 and 2016 and 2018 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	1	0	1
2001	2	0	2
2002	2	0	2
2004	1	0	1
2008	0	1	1
2009	1	0	1
2011	0	1	1
2015	1	0	1
2016	2	0	2
2018	1	1	2
2019	0	1	1
2020	2	0	2
2021	1	0	1

Below are the most recent publications written about "Receptors, Serotonin" by people in Profiles.

Ofori E, Onyameh EK, Gonela UM, Voshavar C, Bricker B, Swanson TL, Eshleman AJ, Schmachtenberg JL, Bloom SH, Janowsky AJ, Ablordeppey SY. New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263. Eur J Med Chem. 2021 Mar 15; 214:113243.

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Karki A, Namballa HK, Alberts I, Harding WW. Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT7AR ligands. Bioorg Med Chem. 2020 08 01; 28(15):115578.

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Giri R, Alberts I, Harding WW. Synthesis, pharmacological evaluations, and molecular docking studies on a new 1,3,4,11b-tetrahydro-1H-fluoreno[9,1-cd]azepine framework: Rigidification of D1 receptor selective 1-phenylbenzazepines and discovery of a new 5-HT6 receptor scaffold. Chem Biol Drug Des. 2020 08; 96(2):825-835.

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Onyameh EK, Bricker BA, Ofori E, Ablordeppey SY. Enantioseparation of 5-chloro-2-{2-[3,4-dihydroisoquinoline-2(1H)-yl]ethyl}-2-methyl-2,3-dihydro-1H-inden-1-one (SYA 40247), a high-affinity 5-HT7 receptor ligand, by HPLC-PDA using amylose tris-(3, 5- dimethylphenylcarbamate) as a chiral stationary phase. Biomed Chromatogr. 2019 Sep; 33(9):e4565.

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Marchant JS, Harding WW, Chan JD. Structure-activity profiling of alkaloid natural product pharmacophores against a Schistosoma serotonin receptor. Int J Parasitol Drugs Drug Resist. 2018 12; 8(3):550-558.

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Njie-Mbye YF, Robinson J, Mitchell-Bush L, Mckoy M, Opere CA, Ohia SE, Sharif N. Pharmacology of Serotonin Receptors Causing Contraction of Isolated Bovine Posterior Ciliary Arteries: Role in Ocular Blood Flow. J Ocul Pharmacol Ther. 2018 Jan/Feb; 34(1-2):134-140.

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Ofori E, Zhu XY, Etukala JR, Bricker BA, Ablordeppey SY. Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors. Bioorg Med Chem. 2016 11 15; 24(22):5730-5740.

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Ofori E, Zhu XY, Etukala JR, Peprah K, Jordan KR, Adkins AA, Bricker BA, Kang HJ, Huang XP, Roth BL, Ablordeppey SY. Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands. Bioorg Med Chem. 2016 08 15; 24(16):3464-71.

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Madapa S, Harding WW. Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors. J Nat Prod. 2015 Apr 24; 78(4):722-9.

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Peprah K, Zhu XY, Eyunni SV, Setola V, Roth BL, Ablordeppey SY. Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents. Bioorg Med Chem. 2012 Feb 01; 20(3):1291-7.

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