"Receptor, PAR-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.
| Descriptor ID |
D044464
|
| MeSH Number(s) |
D12.776.543.750.695.035 D12.776.543.750.792.249
|
| Concept/Terms |
Receptor, PAR-2- Receptor, PAR-2
- Receptor, PAR 2
- Trypsin Receptors
- Receptors, Trypsin
- Trypsin Receptor
- PAR2 Receptor
- Receptor, PAR2
- Proteinase Activated Receptor 2
- Protease-Activated Receptor 2
- Protease Activated Receptor 2
- Receptor 2, Protease-Activated
- Receptor, Trypsin
- PAR-2 Receptor
- PAR 2 Receptor
|
Below are MeSH descriptors whose meaning is more general than "Receptor, PAR-2".
Below are MeSH descriptors whose meaning is more specific than "Receptor, PAR-2".
This graph shows the total number of publications written about "Receptor, PAR-2" by people in this website by year, and whether "Receptor, PAR-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptor, PAR-2" by people in Profiles.
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Ocak U, Eser Ocak P, Huang L, Xu W, Zuo Y, Li P, Gamdzyk M, Zuo G, Mo J, Zhang G, Zhang JH. Inhibition of mast cell tryptase attenuates neuroinflammation via PAR-2/p38/NF?B pathway following asphyxial cardiac arrest in rats. J Neuroinflammation. 2020 May 04; 17(1):144.
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Tillery LC, Epperson TA, Eguchi S, Motley ED. Featured Article: Differential regulation of endothelial nitric oxide synthase phosphorylation by protease-activated receptors in adult human endothelial cells. Exp Biol Med (Maywood). 2016 Mar; 241(6):569-80.
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Watts VL, Motley ED. Role of protease-activated receptor-1 in endothelial nitric oxide synthase-Thr495 phosphorylation. Exp Biol Med (Maywood). 2009 Feb; 234(2):132-9.