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Zimei Bu, PhD

TitleProfessor
Faculty RankProfessor
InstitutionCity College, CUNY
DepartmentChemistry and Biochemistry
Address160 Convent Avenue
MR-1305
Department of Chemistry
New York NY 10031
Phone2126506071
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    Collapse Research 
    Collapse research activities and funding
    F32GM017564     (BU, ZIMEI)Mar 20, 1996
    NIH
    ASSOCIATION STATES &ENERGETICS OF TRANMEMBRANE PROTEIN
    Role: Principal Investigator
    R01HL086496     (BU, ZIMEI)Jul 15, 2007 - Jun 30, 2013
    NIH
    Struture snd Dynamic Determinants of Ion Channel Assembly by Adapter Proteins
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hui B, Bu Z, Cheng X. Role of vinculin in the structural dynamics of cadherin-catenin complexes and its implications for F-actin binding. Protein Sci. 2025 Sep; 34(9):e70259. PMID: 40815272.
      Citations:    Fields:    Translation:HumansCells
    2. Callaway DJE, Nicholl ID, Shi B, Reyes G, Farago B, Bu Z. Nanoscale dynamics of the cadherin-catenin complex bound to vinculin revealed by neutron spin echo spectroscopy. Proc Natl Acad Sci U S A. 2024 Sep 24; 121(39):e2408459121. PMID: 39298480.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Shi B, Matsui T, Qian S, Weiss TM, Nicholl ID, Callaway DJE, Bu Z. An ensemble of cadherin-catenin-vinculin complex employs vinculin as the major F-actin binding mode. Biophys J. 2023 06 20; 122(12):2456-2474. PMID: 37147801.
      Citations: 7     Fields:    Translation:Cells
    4. Farago B, Nicholl ID, Wang S, Cheng X, Callaway DJE, Bu Z. Activated nanoscale actin-binding domain motion in the catenin-cadherin complex revealed by neutron spin echo spectroscopy. Proc Natl Acad Sci U S A. 2021 03 30; 118(13). PMID: 33753508.
      Citations: 8     Fields:    Translation:HumansCells
    5. Bush M, Alhanshali BM, Qian S, Stanley CB, Heller WT, Matsui T, Weiss TM, Nicholl ID, Walz T, Callaway DJE, Bu Z. An ensemble of flexible conformations underlies mechanotransduction by the cadherin-catenin adhesion complex. Proc Natl Acad Sci U S A. 2019 10 22; 116(43):21545-21555. PMID: 31591245.
      Citations: 23     Fields:    Translation:HumansCells
    6. Bhattacharya S, Stanley CB, Heller WT, Friedman PA, Bu Z. Dynamic structure of the full-length scaffolding protein NHERF1 influences signaling complex assembly. J Biol Chem. 2019 07 19; 294(29):11297-11310. PMID: 31171716.
      Citations: 7     Fields:    Translation:HumansCells
    7. Nicholl ID, Matsui T, Weiss TM, Stanley CB, Heller WT, Martel A, Farago B, Callaway DJE, Bu Z. a-Catenin Structure and Nanoscale Dynamics in Solution and in Complex with F-Actin. Biophys J. 2018 08 21; 115(4):642-654. PMID: 30037495.
      Citations: 12     Fields:    Translation:HumansCells
    8. Mamonova T, Zhang Q, Chandra M, Collins BM, Sarfo E, Bu Z, Xiao K, Bisello A, Friedman PA. Origins of PDZ Binding Specificity. A Computational and Experimental Study Using NHERF1 and the Parathyroid Hormone Receptor. Biochemistry. 2017 05 23; 56(20):2584-2593. PMID: 28376304.
      Citations: 10     Fields:    Translation:HumansCells
    9. Callaway DJE, Matsui T, Weiss T, Stingaciu LR, Stanley CB, Heller WT, Bu Z. Controllable Activation of Nanoscale Dynamics in a Disordered Protein Alters Binding Kinetics. J Mol Biol. 2017 04 07; 429(7):987-998. PMID: 28285124.
      Citations: 5     Fields:    Translation:HumansCells
    10. Callaway DJ, Bu Z. Visualizing the nanoscale: protein internal dynamics and neutron spin echo spectroscopy. Curr Opin Struct Biol. 2017 02; 42:1-5. PMID: 27756047.
      Citations: 5     Fields:    Translation:Cells
    11. Callaway DJ, Bu Z. Essential Strategies for Revealing Nanoscale Protein Dynamics by Neutron Spin Echo Spectroscopy. Methods Enzymol. 2016; 566:253-70. PMID: 26791982.
      Citations: 5     Fields:    Translation:Cells
    12. Mamonova T, Zhang Q, Khajeh JA, Bu Z, Bisello A, Friedman PA. Canonical and Noncanonical Sites Determine NPT2A Binding Selectivity to NHERF1 PDZ1. PLoS One. 2015; 10(6):e0129554. PMID: 26070212.
      Citations: 14     Fields:    Translation:HumansCells
    13. Callaway DJ, Bu Z. Nanoscale protein domain motion and long-range allostery in signaling proteins- a view from neutron spin echo sprectroscopy. Biophys Rev. 2015 Jun; 7(2):165-174. PMID: 26005503.
      Citations:    
    14. Chen X, Khajeh JA, Ju JH, Gupta YK, Stanley CB, Do C, Heller WT, Aggarwal AK, Callaway DJ, Bu Z. Phosphatidylinositol 4,5-bisphosphate clusters the cell adhesion molecule CD44 and assembles a specific CD44-Ezrin heterocomplex, as revealed by small angle neutron scattering. J Biol Chem. 2015 Mar 06; 290(10):6639-52. PMID: 25572402.
      Citations: 24     Fields:    Translation:AnimalsCells
    15. Ali Khajeh J, Ju JH, Atchiba M, Allaire M, Stanley C, Heller WT, Callaway DJ, Bu Z. Molecular conformation of the full-length tumor suppressor NF2/Merlin--a small-angle neutron scattering study. J Mol Biol. 2014 Jul 29; 426(15):2755-68. PMID: 24882693.
      Citations: 16     Fields:    Translation:HumansCells
    16. Callaway DJ, Farago B, Bu Z. Nanoscale protein dynamics: a new frontier for neutron spin echo spectroscopy. Eur Phys J E Soft Matter. 2013 Jul; 36(7):76. PMID: 23884624.
      Citations: 11     Fields:    Translation:AnimalsCells
    17. Bhattacharya S, Ju JH, Orlova N, Khajeh JA, Cowburn D, Bu Z. Ligand-induced dynamic changes in extended PDZ domains from NHERF1. J Mol Biol. 2013 Jul 24; 425(14):2509-28. PMID: 23583913.
      Citations: 19     Fields:    Translation:Cells
    18. Jayasundar JJ, Ju JH, He L, Liu D, Meilleur F, Zhao J, Callaway DJ, Bu Z. Open conformation of ezrin bound to phosphatidylinositol 4,5-bisphosphate and to F-actin revealed by neutron scattering. J Biol Chem. 2012 Oct 26; 287(44):37119-33. PMID: 22927432.
      Citations: 29     Fields:    Translation:HumansCells
    19. Bu Z, Callaway DJ. Proteins move! Protein dynamics and long-range allostery in cell signaling. Adv Protein Chem Struct Biol. 2011; 83:163-221. PMID: 21570668.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    20. Farago B, Li J, Cornilescu G, Callaway DJ, Bu Z. Activation of nanoscale allosteric protein domain motion revealed by neutron spin echo spectroscopy. Biophys J. 2010 Nov 17; 99(10):3473-82. PMID: 21081097.
      Citations: 22     Fields:    Translation:Cells
    21. Bhattacharya S, Dai Z, Li J, Baxter S, Callaway DJE, Cowburn D, Bu Z. A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation. J Biol Chem. 2010 Mar 26; 285(13):9981-9994. PMID: 20042604.
      Citations: 29     Fields:    Translation:HumansCells
    22. Li J, Callaway DJ, Bu Z. Ezrin induces long-range interdomain allostery in the scaffolding protein NHERF1. J Mol Biol. 2009 Sep 11; 392(1):166-80. PMID: 19591839.
      Citations: 31     Fields:    Translation:HumansCells
    23. Cheng H, Li J, Fazlieva R, Dai Z, Bu Z, Roder H. Autoinhibitory interactions between the PDZ2 and C-terminal domains in the scaffolding protein NHERF1. Structure. 2009 May 13; 17(5):660-9. PMID: 19446522.
      Citations: 19     Fields:    Translation:Cells
    24. Samuel D, Cheng H, Riley PW, Canutescu AA, Nagaswami C, Weisel JW, Bu Z, Walsh PN, Roder H. Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activation. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15693-8. PMID: 17884987.
      Citations: 14     Fields:    Translation:Cells
    25. Dawson JP, Bu Z, Lemmon MA. Ligand-induced structural transitions in ErbB receptor extracellular domains. Structure. 2007 Aug; 15(8):942-54. PMID: 17697999.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    26. Li J, Poulikakos PI, Dai Z, Testa JR, Callaway DJE, Bu Z. Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assembly. J Biol Chem. 2007 Sep 14; 282(37):27086-27099. PMID: 17613530.
      Citations: 45     Fields:    Translation:HumansCells
    27. Bu Z, Shi Y, Callaway DJ, Tycko R. Molecular alignment within beta-sheets in Abeta(14-23) fibrils: solid-state NMR experiments and theoretical predictions. Biophys J. 2007 Jan 15; 92(2):594-602. PMID: 17056725.
      Citations: 25     Fields:    Translation:Cells
    28. Bu Z, Biehl R, Monkenbusch M, Richter D, Callaway DJ. Coupled protein domain motion in Taq polymerase revealed by neutron spin-echo spectroscopy. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17646-51. PMID: 16306270.
      Citations: 48     Fields:    Translation:Cells
    29. Shi Y, Stouten PF, Pillalamarri N, Barile L, Rosal RV, Teichberg S, Bu Z, Callaway DJ. Quantitative determination of the topological propensities of amyloidogenic peptides. Biophys Chem. 2006 Mar 01; 120(1):55-61. PMID: 16288953.
      Citations: 3     Fields:    Translation:Cells
    30. Li J, Dai Z, Jana D, Callaway DJ, Bu Z. Ezrin controls the macromolecular complexes formed between an adapter protein Na+/H+ exchanger regulatory factor and the cystic fibrosis transmembrane conductance regulator. J Biol Chem. 2005 Nov 11; 280(45):37634-43. PMID: 16129695.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    31. Ho DL, Byrnes WM, Ma WP, Shi Y, Callaway DJ, Bu Z. Structure-specific DNA-induced conformational changes in Taq polymerase revealed by small angle neutron scattering. J Biol Chem. 2004 Sep 10; 279(37):39146-54. PMID: 15247286.
      Citations: 12     Fields:    Translation:Cells
    32. Bu Z, Wang L, Kendall DA. Nucleotide binding induces changes in the oligomeric state and conformation of Sec A in a lipid environment: a small-angle neutron-scattering study. J Mol Biol. 2003 Sep 05; 332(1):23-30. PMID: 12946344.
      Citations: 25     Fields:    Translation:Cells
    33. Tjernberg LO, Tjernberg A, Bark N, Shi Y, Ruzsicska BP, Bu Z, Thyberg J, Callaway DJ. Assembling amyloid fibrils from designed structures containing a significant amyloid beta-peptide fragment. Biochem J. 2002 Aug 15; 366(Pt 1):343-51. PMID: 12023906.
      Citations: 12     Fields:    Translation:HumansCells
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