MAP Kinase Signaling System

"MAP Kinase Signaling System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.

Descriptor ID	D020935
MeSH Number(s)	G02.111.820.560 G03.493.560 G04.835.560
Concept/Terms	MAP Kinase Signaling System MAP Kinase Signaling System ERK1-2 Pathway ERK1-2 Pathway ERK1 2 Pathway ERK1-2 Pathways Pathway, ERK1-2 Pathways, ERK1-2 ERK1 and ERK2 Pathway p38 Kinase Pathway p38 Kinase Pathway Kinase Pathway, p38 Kinase Pathways, p38 Pathway, p38 Kinase Pathways, p38 Kinase p38 Kinase Pathways p38 Kinase Signaling Pathway MAP Kinase Cascade MAP Kinase Cascade Cascade, MAP Kinase Kinase Cascade, MAP MAP Kinase Cascades MAP Kinase Modules MAP Kinase Module Module, MAP Kinase MAP Kinase Signaling Cascades MAP Kinase Signaling Pathways MAP Kinase Signaling Pathways MEK-ERK Pathway MEK-ERK Pathway MEK ERK Pathway MEK-ERK Pathways Pathway, MEK-ERK Pathways, MEK-ERK ERK Signal Tranduction Pathway ERK Signal Tranduction Pathway ERK Pathway ERK Pathways Pathway, ERK Pathways, ERK JNK Pathway JNK Pathway JNK Pathways Pathway, JNK Pathways, JNK JNK Signaling Pathway JNK Signaling Pathways Pathway, JNK Signaling Pathways, JNK Signaling Signaling Pathway, JNK Signaling Pathways, JNK

Below are MeSH descriptors whose meaning is more general than "MAP Kinase Signaling System".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Signal Transduction [G02.111.820]
MAP Kinase Signaling System [G02.111.820.560]
Metabolism [G03]
Metabolic Networks and Pathways [G03.493]
MAP Kinase Signaling System [G03.493.560]
Cell Physiological Phenomena [G04]
Signal Transduction [G04.835]
MAP Kinase Signaling System [G04.835.560]

Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Signaling System".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "MAP Kinase Signaling System" by people in this website by year, and whether "MAP Kinase Signaling System" was a major or minor topic of these publications.

Bar chart showing 145 publications over 27 distinct years, with a maximum of 12 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	2	1	3
2001	1	2	3
2002	4	3	7
2003	1	2	3
2004	0	4	4
2005	1	4	5
2006	0	1	1
2007	2	1	3
2008	4	2	6
2009	2	2	4
2010	1	3	4
2011	2	6	8
2012	3	2	5
2013	3	3	6
2014	3	6	9
2015	4	3	7
2016	3	5	8
2017	3	4	7
2018	7	5	12
2019	6	2	8
2020	6	5	11
2021	2	6	8
2022	1	2	3
2023	0	1	1
2024	1	4	5
2025	1	2	3

Below are the most recent publications written about "MAP Kinase Signaling System" by people in Profiles.

Gutierrez DA, Robles-Escajeda E, Lopez-Saenz JA, Kirken RA, Borrego EA, Betancourt AP, Nair S, Roy S, Varela-Ramirez A, Aguilera RJ. Discovery of Two Novel Pyrazole Derivatives as Anticancer Agents Targeting Tubulin Polymerization and MAPK Signaling Pathways. Oncol Res. 2026; 34(4):14.

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Morales-Cab?n BM, Cantres-Rosario YM, Tosado-Rodr?guez EL, Roche-Lima A, Mel?ndez LM, Boukli NM, Suarez-Arroyo IJ. SCAMP3-Driven Regulation of ERK1/2 and Autophagy Phosphoproteomics Signatures in Triple-Negative Breast Cancer. Int J Mol Sci. 2025 Oct 01; 26(19).

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Lazarte JMS, Ofosu-Asante K, Tilghman SL, Lamango NS. PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion. Oncotarget. 2025 Jul 29; 16:621-641.

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Abdou HM, Hamaad FA, Elmageed GMA, Katano H, Ghoneum MH. Efficacy of Plasmalogens on Monosodium Glutamate-Induced Neurotoxicity in Male Rats Through NF-?B and p38 MAPK Signaling Pathways. Oxid Med Cell Longev. 2025; 2025:3673280.

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Anaya YA, Bracho RP, Chauhan SC, Tripathi MK, Bandyopadhyay D. Small Molecule B-RAF Inhibitors as Anti-Cancer Therapeutics: Advances in Discovery, Development, and Mechanistic Insights. Int J Mol Sci. 2025 Mar 16; 26(6).

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Gregory MD, Ofosu-Asante K, Lazarte JMS, Puente PE, Tawfeeq N, Belony N, Huang Y, Offringa IA, Lamango NS. Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis. PLoS One. 2024; 19(10):e0312563.

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Alicia SV, Rivera-Moctezuma FG, Marrero Valent?n JL, P?rez D, Tosado-Rodr?guez EL, Roche Lima A, Ferchmin PA, Sabeva N. Neuroprotection by 4R-cembranoid against Gulf War Illness-related Chemicals is mediated by ERK, PI3K, and CaMKII pathways. Neuropharmacology. 2025 02 15; 264:110199.

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Ham H, Jing H, Lamborn IT, Kober MM, Koval A, Berchiche YA, Anderson DE, Druey KM, Mandl JN, Isidor B, Ferreira CR, Freeman AF, Ganesan S, Karsak M, Mustillo PJ, Teo J, Zolkipli-Cunningham Z, Chatron N, Lecoquierre F, Oler AJ, Schmid JP, Kuhns DB, Xu X, Hauck F, Al-Herz W, Wagner M, Terhal PA, Muurinen M, Barlogis V, Cruz P, Danielson J, Stewart H, Loid P, Rading S, Keren B, Pfundt R, Zarember KA, Vill K, Potocki L, Olivier KN, Lesca G, Faivre L, Wong M, Puel A, Chou J, Tusseau M, Moutsopoulos NM, Matthews HF, Simons C, Taft RJ, Soldatos A, Masle-Farquhar E, Pittaluga S, Brink R, Fink DL, Kong HH, Kabat J, Kim WS, Bierhals T, Meguro K, Hsu AP, Gu J, Stoddard J, Banos-Pinero B, Slack M, Trivellin G, Mazel B, Soomann M, Li S, Watts VJ, Stratakis CA, Rodriguez-Quevedo MF, Bruel AL, Lipsanen-Nyman M, Saultier P, Jain R, Lehalle D, Torres D, Sullivan KE, Barbarot S, Neu A, Duffourd Y, Similuk M, McWalter K, Blanc P, B?zieau S, Jin T, Geha RS, Casanova JL, Makitie OM, Kubisch C, Edery P, Christodoulou J, Germain RN, Goodnow CC, Sakmar TP, Billadeau DD, K?ry S, Katanaev VL, Zhang Y, Lenardo MJ, Su HC. Germline mutations in a G protein identify signaling cross-talk in T cells. Science. 2024 09 20; 385(6715):eadd8947.

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Wu L, Liu Y, He Q, Ao G, Xu N, He W, Liu X, Huang L, Yu Q, Kanamaru H, Dong S, Zhu S, Yuan Y, Han M, Ling Y, Liu L, Wu C, Zhou Y, Sherchan P, Flores JJ, Tang J, Chen X, He X, Zhang JH. PEDF-34 attenuates neurological deficit and suppresses astrocyte-dependent neuroinflammation by modulating astrocyte polarization via 67LR/JNK/STAT1 signaling pathway after subarachnoid hemorrhage in rats. J Neuroinflammation. 2024 Jul 21; 21(1):178.

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Liu L, Wu Y, Liu K, Zhu M, Guang S, Wang F, Liu X, Yao X, He J, Fu C. The absence of the ribosomal protein Rpl2702 elicits the MAPK-mTOR signaling to modulate mitochondrial morphology and functions. Redox Biol. 2024 07; 73:103174.

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