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Nazarius S. Lamango

TitleProfessor of Medicinal Chemistry
Faculty RankProfessor
InstitutionFlorida A&M University
DepartmentCoPPS, IPH Pharmaceutical Sciences
Address1415 S Martin Luther King Jr Blvd
Tallahassee FL 32307
Phone8504127377
Fax8505993347
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lazarte JMS, Lamango NS. Activation of MAP Kinase Pathway by Polyisoprenylated Cysteinyl Amide Inhibitors Causes Apoptosis and Disrupts Breast Cancer Cell Invasion. Biomedicines. 2024 Feb 20; 12(3). PMID: 38540084.
      Citations:    
    2. Leon C, Manley E, Neely AM, Castillo J, Ramos Correa M, Velarde DA, Yang M, Puente PE, Romero DI, Ren B, Chai W, Gladstone M, Lamango NS, Huang Y, Offringa IA. Lack of racial and ethnic diversity in lung cancer cell lines contributes to lung cancer health disparities. Front Oncol. 2023; 13:1187585. PMID: 38023251.
      Citations:    
    3. Ren B, Chiaravalloti TR, Belony NL, Romero DI, Chai W, Leon C, Wu L, Lamango NS, Offringa IA, Huang Y. Design and Realization of Lung Organoid Cultures for COVID-19 Applications. Biodes Manuf. 2023 Nov; 6(6):646-660. PMID: 38993804.
      Citations:    
    4. Tawfeeq N, Lazarte JMS, Jin Y, Gregory MD, Lamango NS. Polyisoprenylated cysteinyl amide inhibitors deplete singly polyisoprenylated monomeric G-proteins in lung and breast cancer cell lines. Oncotarget. 2023 03 24; 14:243-257. PMID: 36961909.
      Citations: 1     Fields:    Translation:HumansCells
    5. Reams RR, Odedina FT, Carpten JD, Redda K, Stern MC, Krieger JL, Aparicio J, Hensel B, Askins N, Abreu A, Adams A, Agyare E, Ali J, Allen JM, Al? R, Baezconde-Garbanati L, Brant J, Brown CP, Buxbaum SG, Cohen P, Cozen W, Ezenwa MO, Falzarano S, Fillingim RB, Flores-Rozas H, Fredenburg KM, George T, Han B, Huang Y, Hughes Halbert C, Kiros GE, Lamango NS, Lee JH, Lyon DE, Mitchell DA, Mochona B, Nieva JJ, Offringa IA, Okunieff P, Parker A, Rhie SK, Richey JM, Rogers SC, Salhia B, Schmittgen TD, Segal R, Setiawan VW, Smith U, Su LM, Suther S, Trevino J, Velazquez-Villarreal EI, Webb FJ, Wu AH, Yao Y, Wilkie DJ. Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center: Structure, Innovations, and Initial Outcomes. Cancer Control. 2023 Jan-Dec; 30:10732748231197878. PMID: 37703814.
      Citations: 1     Fields:    Translation:Humans
    6. Asong GM, Voshavar C, Amissah F, Bricker B, Lamango NS, Ablordeppey SY. An Evaluation of the Anticancer Properties of SYA014, a Homopiperazine-Oxime Analog of Haloperidol in Triple Negative Breast Cancer Cells. Cancers (Basel). 2022 Dec 08; 14(24). PMID: 36551533.
      Citations:    
    7. Tawfeeq N, Jin Y, Lamango NS. Synthetic Optimization and MAPK Pathway Activation Anticancer Mechanism of Polyisoprenylated Cysteinyl Amide Inhibitors. Cancers (Basel). 2021 Nov 17; 13(22). PMID: 34830912.
      Citations:    
    8. Lamango NS, Nkembo AT, Ntantie E, Tawfeeq N. Polyisoprenylated Cysteinyl Amide Inhibitors: A Novel Approach to Controlling Cancers with Hyperactive Growth Signaling. Curr Med Chem. 2021; 28(18):3476-3489. PMID: 33176634.
      Citations: 2     Fields:    Translation:HumansCells
    9. Asong GM, Amissah F, Voshavar C, Nkembo AT, Ntantie E, Lamango NS, Ablordeppey SY. A Mechanistic Investigation on the Anticancer Properties of SYA013, a Homopiperazine Analogue of Haloperidol with Activity against Triple Negative Breast Cancer Cells. ACS Omega. 2020 Dec 29; 5(51):32907-32918. PMID: 33403252.
      Citations:    
    10. Asong G, Zhu XY, Bricker B, Andey T, Amissah F, Lamango N, Ablordeppey SY. New analogs of SYA013 as sigma-2 ligands with anticancer activity. Bioorg Med Chem. 2019 06 15; 27(12):2629-2636. PMID: 30987780.
      Citations: 4     Fields:    Translation:HumansCells
    11. Nkembo AT, Amissah F, Ntantie E, Poku RA, Salako OO, Ikpatt OF, Lamango NS. Polyisoprenylated Cysteinyl Amide Inhibitors Deplete K-Ras and Induce Caspase-dependent Apoptosis in Lung Cancer Cells. Curr Cancer Drug Targets. 2019; 19(10):838-851. PMID: 30914025.
      Citations: 6     Fields:    Translation:HumansCells
    12. Ntantie E, Allen MJ, Fletcher J, Nkembo AT, Lamango NS, Ikpatt OF. Suppression of focal adhesion formation may account for the suppression of cell migration, invasion and growth of non-small cell lung cancer cells following treatment with polyisoprenylated cysteinyl amide inhibitors. Oncotarget. 2018 May 25; 9(40):25781-25795. PMID: 29899821.
      Citations: 7     Fields:    
    13. Poku RA, Salako OO, Amissah F, Nkembo AT, Ntantie E, Lamango NS. Polyisoprenylated cysteinyl amide inhibitors induce caspase 3/7- and 8-mediated apoptosis and inhibit migration and invasion of metastatic prostate cancer cells. Am J Cancer Res. 2017; 7(7):1515-1527. PMID: 28744401.
      Citations:    
    14. Ntantie E, Fletcher J, Amissah F, Salako OO, Nkembo AT, Poku RA, Ikpatt FO, Lamango NS. Polyisoprenylated cysteinyl amide inhibitors disrupt actin cytoskeleton organization, induce cell rounding and block migration of non-small cell lung cancer. Oncotarget. 2017 May 09; 8(19):31726-31744. PMID: 28423648.
      Citations: 13     Fields:    Translation:HumansCells
    15. Nkembo AT, Salako O, Poku RA, Amissah F, Ntantie E, Flores-Rozas H, Lamango NS. Disruption of actin filaments and suppression of pancreatic cancer cell viability and migration following treatment with polyisoprenylated cysteinyl amides. Am J Cancer Res. 2016; 6(11):2532-2546. PMID: 27904769.
      Citations:    
    16. Nkembo AT, Ntantie E, Salako OO, Amissah F, Poku RA, Latinwo LM, Lamango NS. The antiangiogenic effects of polyisoprenylated cysteinyl amide inhibitors in HUVEC, chick embryo and zebrafish is dependent on the polyisoprenyl moiety. Oncotarget. 2016 Oct 18; 7(42):68194-68205. PMID: 27626690.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    17. Sierra-Fonseca JA, Najera O, Martinez-Jurado J, Walker EM, Varela-Ramirez A, Khan AM, Miranda M, Lamango NS, Roychowdhury S. Nerve growth factor induces neurite outgrowth of PC12 cells by promoting G??-microtubule interaction. BMC Neurosci. 2014 Dec 31; 15:132. PMID: 25552352.
      Citations: 25     Fields:    Translation:AnimalsCells
    18. Poku RA, Amissah F, Duverna R, Aguilar BJ, Kiros GE, Lamango NS. Polyisoprenylated methylated protein methyl esterase as a putative drug target for androgen-insensitive prostate cancer. Ecancermedicalscience. 2014; 8:459. PMID: 25228915.
      Citations:    
    19. Sampson D, Bricker B, Zhu XY, Peprah K, Lamango NS, Setola V, Roth BL, Ablordeppey SY. Further evaluation of the tropane analogs of haloperidol. Bioorg Med Chem Lett. 2014 Sep 01; 24(17):4294-7. PMID: 25070422.
      Citations: 5     Fields:    Translation:AnimalsCells
    20. Aguilar BJ, Nkembo AT, Duverna R, Poku RA, Amissah F, Ablordeppey SY, Lamango NS. Polyisoprenylated methylated protein methyl esterase: a putative biomarker and therapeutic target for pancreatic cancer. Eur J Med Chem. 2014 Jun 23; 81:323-33. PMID: 24852279.
      Citations: 11     Fields:    Translation:HumansCells
    21. Sampson D, Zhu XY, Eyunni SV, Etukala JR, Ofori E, Bricker B, Lamango NS, Setola V, Roth BL, Ablordeppey SY. Identification of a new selective dopamine D4 receptor ligand. Bioorg Med Chem. 2014 Jun 15; 22(12):3105-14. PMID: 24800940.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    22. Amissah F, Duverna R, Aguilar BJ, Poku RA, Kiros GE, Lamango NS. Polyisoprenylated methylated protein methyl esterase overexpression and hyperactivity promotes lung cancer progression. Am J Cancer Res. 2014; 4(2):116-34. PMID: 24660102.
      Citations:    
    23. Amissah F, Duverna R, Aguilar BJ, Poku RA, Lamango NS. Polyisoprenylated methylated protein methyl esterase is both sensitive to curcumin and overexpressed in colorectal cancer: implications for chemoprevention and treatment. Biomed Res Int. 2013; 2013:416534. PMID: 23936796.
      Citations: 10     Fields:    Translation:HumansCells
    24. Ayuk-Takem L, Amissah F, Aguilar BJ, Lamango NS. Inhibition of polyisoprenylated methylated protein methyl esterase by synthetic musks induces cell degeneration. Environ Toxicol. 2014 Apr; 29(4):466-77. PMID: 22489002.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    25. Amissah F, Taylor S, Duverna R, Ayuk-Takem LT, Lamango NS. Regulation of polyisoprenylated methylated protein methyl esterase by polyunsaturated fatty acids and prostaglandins. Eur J Lipid Sci Technol. 2011 Nov; 113(11):1321-1331. PMID: 22468134.
      Citations:    
    26. Aguilar B, Amissah F, Duverna R, Lamango NS. Polyisoprenylation potentiates the inhibition of polyisoprenylated methylated protein methyl esterase and the cell degenerative effects of sulfonyl fluorides. Curr Cancer Drug Targets. 2011 Jul; 11(6):752-62. PMID: 21599633.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    27. Duverna R, Ablordeppey SY, Lamango NS. Biochemical and docking analysis of substrate interactions with polyisoprenylated methylated protein methyl esterase. Curr Cancer Drug Targets. 2010 Sep; 10(6):634-48. PMID: 20491620.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    28. Lamango NS, Duverna R, Zhang W, Ablordeppey SY. Porcine Liver Carboxylesterase Requires Polyisoprenylation for High Affinity Binding to Cysteinyl Substrates. Open Enzym Inhib J. 2009 Jan 01; 2:12-27. PMID: 20664805.
      Citations:    
    29. Oboh OT, Lamango NS. Liver prenylated methylated protein methyl esterase is the same enzyme as Sus scrofa carboxylesterase. J Biochem Mol Toxicol. 2008 Feb; 22(1):51-62. PMID: 18273909.
      Citations: 18     Fields:    Translation:AnimalsCells
    30. Lee DC, Womble TA, Mason CW, Jackson IM, Lamango NS, Severs WB, Palm DE. 6-Hydroxydopamine induces cystatin C-mediated cysteine protease suppression and cathepsin D activation. Neurochem Int. 2007 Mar; 50(4):607-18. PMID: 17241700.
      Citations: 2     Fields:    Translation:AnimalsCells
    31. Isaac RE, Lamango NS, Ekbote U, Taylor CA, Hurst D, Weaver RJ, Carhan A, Burnham S, Shirras AD. Angiotensin-converting enzyme as a target for the development of novel insect growth regulators. Peptides. 2007 Jan; 28(1):153-62. PMID: 17157962.
      Citations: 13     Fields:    Translation:Animals
    32. Shepherd KR, Lee ES, Schmued L, Jiao Y, Ali SF, Oriaku ET, Lamango NS, Soliman KF, Charlton CG. The potentiating effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on paraquat-induced neurochemical and behavioral changes in mice. Pharmacol Biochem Behav. 2006 Mar; 83(3):349-59. PMID: 16580056.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    33. Lamango NS. Liver prenylated methylated protein methyl esterase is an organophosphate-sensitive enzyme. J Biochem Mol Toxicol. 2005; 19(5):347-57. PMID: 16292756.
      Citations: 13     Fields:    Translation:AnimalsCells
    34. Lee ES, Chen H, Shepherd KR, Lamango NS, Soliman KF, Charlton CG. Inhibitory effects of lysophosphatidylcholine on the dopaminergic system. Neurochem Res. 2004 Jul; 29(7):1333-42. PMID: 15202762.
      Citations: 4     Fields:    Translation:AnimalsCells
    35. Lee ES, Chen H, Shepherd KR, Lamango NS, Soliman KF, Charlton CG. The inhibitory role of methylation on the binding characteristics of dopamine receptors and transporter. Neurosci Res. 2004 Mar; 48(3):335-44. PMID: 15154679.
      Citations: 7     Fields:    Translation:AnimalsCells
    36. Lamango NS, Ayuk-Takem LT, Nesby R, Zhao WQ, Charlton CG. Inhibition mechanism of S-adenosylmethionine-induced movement deficits by prenylcysteine analogs. Pharmacol Biochem Behav. 2003 Dec; 76(3-4):433-42. PMID: 14643842.
      Citations: 6     Fields:    Translation:AnimalsCells
    37. Zhao WQ, Williams Z, Shepherd KR, Reuben JS, Lee ES, Darling-Reed S, Lamango N, Soliman KF, Charlton CG. S-adenosyl-methionine-induced apoptosis in PC12 cells. J Neurosci Res. 2002 Aug 15; 69(4):519-29. PMID: 12210845.
      Citations: 7     Fields:    Translation:AnimalsCells
    38. Lamango NS, Charlton CG. Farnesyl-L-cysteine analogs block SAM-induced Parkinson's disease-like symptoms in rats. Pharmacol Biochem Behav. 2000 Aug; 66(4):841-9. PMID: 10973524.
      Citations: 11     Fields:    Translation:AnimalsCells
    39. Lamango NS, Nesby RA, Charlton CG. Quantification of S-adenosylmethionine-induced tremors: a possible tremor model for Parkinson's disease. Pharmacol Biochem Behav. 2000 Mar; 65(3):523-9. PMID: 10683494.
      Citations: 6     Fields:    Translation:Animals
    40. Lamango NS, Apletalina E, Liu J, Lindberg I. The proteolytic maturation of prohormone convertase 2 (PC2) is a pH-driven process. Arch Biochem Biophys. 1999 Feb 15; 362(2):275-82. PMID: 9989936.
      Citations: 12     Fields:    Translation:AnimalsCells
    41. Johanning K, Juliano MA, Juliano L, Lazure C, Lamango NS, Steiner DF, Lindberg I. Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates. J Biol Chem. 1998 Aug 28; 273(35):22672-80. PMID: 9712897.
      Citations: 25     Fields:    Translation:AnimalsCells
    42. Isaac RE, Lamango NS, Nachman RJ, Strey A, Hayes TK. Angiotensin-converting enzyme and the metabolism of regulatory peptides in insects. Ann N Y Acad Sci. 1997 Apr 24; 814:339-41. PMID: 9160987.
      Citations: 1     Fields:    Translation:Animals
    43. Lamango NS, Nachman RJ, Hayes TK, Strey A, Isaac RE. Hydrolysis of insect neuropeptides by an angiotensin-converting enzyme from the housefly, Musca domestica. Peptides. 1997; 18(1):47-52. PMID: 9114451.
      Citations: 10     Fields:    Translation:Animals
    44. Zhu X, Lamango NS, Lindberg I. Involvement of a polyproline helix-like structure in the interaction of 7B2 with prohormone convertase 2. J Biol Chem. 1996 Sep 20; 271(38):23582-7. PMID: 8798569.
      Citations: 7     Fields:    Translation:AnimalsCells
    45. Lamango NS, Zhu X, Lindberg I. Purification and enzymatic characterization of recombinant prohormone convertase 2: stabilization of activity by 21 kDa 7B2. Arch Biochem Biophys. 1996 Jun 15; 330(2):238-50. PMID: 8660652.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    46. Zhu X, Rouille Y, Lamango NS, Steiner DF, Lindberg I. Internal cleavage of the inhibitory 7B2 carboxyl-terminal peptide by PC2: a potential mechanism for its inactivation. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4919-24. PMID: 8643504.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    47. Lamango NS, Sajid M, Isaac RE. The endopeptidase activity and the activation by Cl- of angiotensin-converting enzyme is evolutionarily conserved: purification and properties of an an angiotensin-converting enzyme from the housefly, Musca domestica. Biochem J. 1996 Mar 01; 314 ( Pt 2):639-46. PMID: 8670080.
      Citations: 5     Fields:    Translation:AnimalsCells
    48. Cornell MJ, Williams TA, Lamango NS, Coates D, Corvol P, Soubrier F, Hoheisel J, Lehrach H, Isaac RE. Cloning and expression of an evolutionary conserved single-domain angiotensin converting enzyme from Drosophila melanogaster. J Biol Chem. 1995 Jun 09; 270(23):13613-9. PMID: 7775412.
      Citations: 42     Fields:    Translation:AnimalsCells
    49. Isaac RE, Lamango NS. Peptidyl dipeptidase activity in the haemolymph of insects. Biochem Soc Trans. 1994 Aug; 22(3):292S. PMID: 7821551.
      Citations: 2     Fields:    Translation:AnimalsCells
    50. Lamango NS, Isaac RE. Identification and properties of a peptidyl dipeptidase in the housefly, Musca domestica, that resembles mammalian angiotensin-converting enzyme. Biochem J. 1994 May 01; 299 ( Pt 3):651-7. PMID: 8192653.
      Citations: 13     Fields:    Translation:AnimalsCells
    51. Lamango NS, Isaac RE. Metabolism of insect neuropeptides: properties of a membrane-bound endopeptidase from heads of Musca domestica. Insect Biochem Mol Biol. 1993 Oct; 23(7):801-8. PMID: 8374613.
      Citations: 4     Fields:    Translation:AnimalsCells
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