Cysteine Endopeptidases

"Cysteine Endopeptidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.

Descriptor ID	D003546
MeSH Number(s)	D08.811.277.656.262.500 D08.811.277.656.300.200
Concept/Terms	Cysteine Endopeptidases Cysteine Endopeptidases

Below are MeSH descriptors whose meaning is more general than "Cysteine Endopeptidases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Cysteine Proteases [D08.811.277.656.262]
Cysteine Endopeptidases [D08.811.277.656.262.500]
Endopeptidases [D08.811.277.656.300]
Cysteine Endopeptidases [D08.811.277.656.300.200]

Below are MeSH descriptors whose meaning is related to "Cysteine Endopeptidases".

Below are MeSH descriptors whose meaning is more specific than "Cysteine Endopeptidases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cysteine Endopeptidases" by people in this website by year, and whether "Cysteine Endopeptidases" was a major or minor topic of these publications.

Bar chart showing 52 publications over 19 distinct years, with a maximum of 7 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1997	0	1	1
1998	1	1	2
1999	5	0	5
2000	2	1	3
2001	1	1	2
2002	1	4	5
2003	1	2	3
2004	4	3	7
2006	2	2	4
2007	1	1	2
2008	0	1	1
2009	2	1	3
2011	2	1	3
2013	2	0	2
2015	1	1	2
2017	1	1	2
2024	1	2	3
2025	1	0	1

Below are the most recent publications written about "Cysteine Endopeptidases" by people in Profiles.

Ho FK, Lam LN, Matysik A, Watts TD, Wong JJ, Chong KKL, Choo PY, Tolar J, Low PM, Chua ZS, Paxman JJ, Heras B, Marsili E, Ajo-Franklin CM, Kline KA. Role of sortase-assembled Ebp pili in Enterococcus faecalis adhesion to iron oxides and its impact on extracellular electron transfer. Microbiol Spectr. 2025 Mar 04; 13(3):e0233724.

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Adeyinka OS, Barrera MD, Metibemu DS, Boghdeh N, Anderson CA, Baha H, Crown O, Falode JA, Bleach JL, Bliss AR, Hampton TP, Ojobor JC, Alem F, Narayanan A, Ogungbe IV. nsP2 Protease Inhibitor Blocks the Replication of New World Alphaviruses and Offer Protection in Mice. ACS Infect Dis. 2025 Jan 10; 11(1):181-196.

View in: PubMed
Metibemu DS, Adeyinka OS, Falode J, Hampton T, Crown O, Ojobor JC, Narayanan A, Julander J, Ogungbe IV. Inhibitor of the non-structural protein 2 protease shows promising efficacy in mouse models of chikungunya. Eur J Med Chem. 2024 Nov 15; 278:116808.

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Colomer-Winter C, Yong AMH, Chong KKL, Veleba M, Choo PY, Gao IH, Matysik A, Ho FK, Chen SL, Kline KA. The HtrA chaperone monitors sortase-assembled pilus biogenesis in Enterococcus faecalis. PLoS Genet. 2024 Aug; 20(8):e1011071.

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Serrano M, Gonzalez V, Ray S, Chavez MD, Narayan M. Identification of Structure-Stabilizing Interactions in Enzymes: A Novel Mechanism to Impact Enzyme Activity. Cell Biochem Biophys. 2018 Jun; 76(1-2):59-71.

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Yu T, Zuo Y, Cai R, Huang X, Wu S, Zhang C, Chin YE, Li D, Zhang Z, Xia N, Wang Q, Shen H, Yao X, Zhang ZY, Xue S, Shen L, Cheng J. SENP1 regulates IFN-?-STAT1 signaling through STAT3-SOCS3 negative feedback loop. J Mol Cell Biol. 2017 04 01; 9(2):144-153.

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Vesper S, Choi H, Perzanowski MS, Acosta LM, Divjan A, Bola?os-Rosero B, Rivera-Mariani F, Chew GL. Mold populations and dust mite allergen concentrations in house dust samples from across Puerto Rico. Int J Environ Health Res. 2016; 26(2):198-207.

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McShan D, Kathman S, Lowe B, Xu Z, Zhan J, Statsyuk A, Ogungbe IV. Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain. Bioorg Med Chem Lett. 2015 Oct 15; 25(20):4509-12.

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Kandaswamy K, Liew TH, Wang CY, Huston-Warren E, Meyer-Hoffert U, Hultenby K, Schr?der JM, Caparon MG, Normark S, Henriques-Normark B, Hultgren SJ, Kline KA. Focal targeting by human ?-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20230-5.

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Nielsen HV, Flores-Mireles AL, Kau AL, Kline KA, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ. Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis. J Bacteriol. 2013 Oct; 195(19):4484-95.

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